Increased methamphetamine‐induced locomotor activity and behavioral sensitization in histamine‐deficient mice

We have recently suggested that the brain histamine has an inhibitory role on the behavioral effects of methamphetamine by pharmacological studies. In this study, we used the histidine decarboxylase gene knockout mice and measured the spontaneous locomotor activity, the changes of locomotion by sing...

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Bibliographic Details
Published in:	Journal of neurochemistry Vol. 83; no. 4; pp. 837 - 845
Main Authors:	Kubota, Yasuhiko, Ito, Chihiro, Sakurai, Eiichi, Sakurai, Eiko, Watanabe, Takehiko, Ohtsu, Hiroshi
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Science Ltd 01-11-2002 Blackwell
Subjects:	3,4-Dihydroxyphenylacetic Acid - analysis Amino Acids - analysis Animals Behavior, Animal - drug effects behavioral sensitization Biological and medical sciences Brain - drug effects Brain - metabolism Brain Chemistry - drug effects Dopamine - analysis GABA gamma-Aminobutyric Acid - analysis histamine Histamine - analysis Histamine - genetics Histamine - metabolism histidine decarboxylase Histidine Decarboxylase - deficiency Histidine Decarboxylase - genetics Homovanillic Acid - analysis Hydroxyindoleacetic Acid - analysis Male Medical sciences methamphetamine Methamphetamine - pharmacology Mice Mice, Inbred Strains Mice, Knockout Motor Activity - drug effects Neuropharmacology noradrenaline Norepinephrine - analysis Pharmacology. Drug treatments Phosphoserine - analysis Photoperiod Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Serotonin - analysis Hyperactivity Central nervous system Metamfetamine Lyases Histidine decarboxylase methamphetamine Carboxy-lyases Sensitization noradrenaline behavioral sensitization CNS stimulant Enzyme Interaction Rodentia Histamine Locomotion Carbon-carbon lyases Vertebrata Mammalia Mouse Animal Neurotransmitter GABA Norepinephrine Mutation
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