Proteomics profiling of urine reveals specific titin fragments as biomarkers of Duchenne muscular dystrophy

Abstract Diagnosis of muscular dystrophies is currently based on invasive methods requiring muscle biopsies or blood tests. The aim of the present study was to identify urinary biomarkers as a diagnostic tool for muscular dystrophies. Here, the urinary proteomes of Duchenne muscular dystrophy (DMD)...

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Bibliographic Details
Published in:	Neuromuscular disorders : NMD Vol. 24; no. 7; pp. 563 - 573
Main Authors:	Rouillon, Jeremy, Zocevic, Aleksandar, Leger, Thibaut, Garcia, Camille, Camadro, Jean-Michel, Udd, Bjarne, Wong, Brenda, Servais, Laurent, Voit, Thomas, Svinartchouk, Fedor
Format:	Journal Article
Language:	English
Published:	England Elsevier B.V 01-07-2014
Subjects:	Adolescent Age Factors Animals Biomarkers Biomarkers - urine Blotting, Western Child Child, Preschool Cohort Studies Connectin - genetics Connectin - urine Creatine Kinase, MM Form - blood DMD diagnosis Dogs Dystrophin Female Humans Male Mass Spectrometry Mice, Inbred C57BL Mice, Transgenic Motor Activity - physiology Muscular dystrophy Muscular Dystrophy, Duchenne - urine Neurology Protein Kinases - genetics Protein Kinases - urine Proteomics - methods Titin fragments Young Adult Biomarkers Titin fragments Dystrophin Muscular dystrophy DMD diagnosis
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