Placental expression of eNOS, iNOS and the major protein components of caveolae in women with pre-eclampsia
Abstract Caveolae regulate many cardiovascular functions and thus could be of interest in relation to pre-eclampsia, a pregnancy specific disorder characterised by hypertension and proteinuria. We examined placental mRNA and protein expression/localisation of the caveolae components Caveolin 1-3, Ca...
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| Published in: | Placenta (Eastbourne) Vol. 36; no. 5; pp. 607 - 610 |
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| Abstract | Abstract Caveolae regulate many cardiovascular functions and thus could be of interest in relation to pre-eclampsia, a pregnancy specific disorder characterised by hypertension and proteinuria. We examined placental mRNA and protein expression/localisation of the caveolae components Caveolin 1-3, Cavin 1-4 as well as eNOS/iNOS in normotensive control (n = 24) and pre-eclamptic pregnancies (n = 19). Placental mRNA expression of caveolin-1 , cavin 1-3 , was lower and eNOS expression was increased in pre-eclampsia ( P < 0.05 for all). Additionally Caveolin-1 protein expression was also reduced in pre-eclampsia ( P = 0.007); this could be an adaptive response in pre-eclampsia, possibly to attenuate the oxidative stress/inflammation. |
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| AbstractList | Caveolae regulate many cardiovascular functions and thus could be of interest in relation to pre-eclampsia, a pregnancy specific disorder characterised by hypertension and proteinuria. We examined placental mRNA and protein expression/localisation of the caveolae components Caveolin 1-3, Cavin 1-4 as well as eNOS/iNOS in normotensive control (n = 24) and pre-eclamptic pregnancies (n = 19). Placental mRNA expression of caveolin-1, cavin 1-3, was lower and eNOS expression was increased in pre-eclampsia (P < 0.05 for all). Additionally Caveolin-1 protein expression was also reduced in pre-eclampsia (P = 0.007); this could be an adaptive response in pre-eclampsia, possibly to attenuate the oxidative stress/inflammation. Abstract Caveolae regulate many cardiovascular functions and thus could be of interest in relation to pre-eclampsia, a pregnancy specific disorder characterised by hypertension and proteinuria. We examined placental mRNA and protein expression/localisation of the caveolae components Caveolin 1-3, Cavin 1-4 as well as eNOS/iNOS in normotensive control (n = 24) and pre-eclamptic pregnancies (n = 19). Placental mRNA expression of caveolin-1 , cavin 1-3 , was lower and eNOS expression was increased in pre-eclampsia ( P < 0.05 for all). Additionally Caveolin-1 protein expression was also reduced in pre-eclampsia ( P = 0.007); this could be an adaptive response in pre-eclampsia, possibly to attenuate the oxidative stress/inflammation. Caveolae regulate many cardiovascular functions and thus could be of interest in relation to pre-eclampsia, a pregnancy specific disorder characterised by hypertension and proteinuria. We examined placental mRNA and protein expression/localisation of the caveolae components Caveolin 1-3, Cavin 1-4 as well as eNOS/iNOS in normotensive control (n = 24) and pre-eclamptic pregnancies (n = 19). Placental mRNA expression of caveolin-1, cavin 1-3, was lower and eNOS expression was increased in pre-eclampsia (P < 0.05 for all). Additionally Caveolin-1 protein expression was also reduced in pre-eclampsia (P = 0.007); this could be an adaptive response in pre-eclampsia, possibly to attenuate the oxidative stress/inflammation. •First report of all components of caveolae expression in human placentae tissue.•Caveolin-1, cavin-1, -2 & 3 mRNA expression was lower in pre-eclamptic placentae.•eNOS mRNA expression was increased in pre-eclamptic placentae.•Caveolin-1 protein expression was also reduced in pre-eclampsia.•Could be an adaptive response to attenuate the oxidative stress and inflammation. |
| Author | Czajka, A Pinheiro da Costa, B.E Poli-de-Figueiredo, C.E Kurlak, L.O Hentschke, M.R Broughton Pipkin, F Mistry, H.D Smith-Jackson, K |
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| Snippet | Abstract Caveolae regulate many cardiovascular functions and thus could be of interest in relation to pre-eclampsia, a pregnancy specific disorder... Caveolae regulate many cardiovascular functions and thus could be of interest in relation to pre-eclampsia, a pregnancy specific disorder characterised by... |
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| SubjectTerms | Case-Control Studies Caveolae - metabolism Caveolin Caveolin 1 - metabolism Cavin Female Humans Hypertension Internal Medicine Nitric Oxide Synthase Type II - metabolism Nitric Oxide Synthase Type III - metabolism Obstetrics and Gynecology Placenta Placenta - metabolism Pre-eclampsia Pre-Eclampsia - metabolism Pregnancy |
| Title | Placental expression of eNOS, iNOS and the major protein components of caveolae in women with pre-eclampsia |
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