Placental expression of eNOS, iNOS and the major protein components of caveolae in women with pre-eclampsia

• Published in: Placenta (Eastbourne) Vol. 36; no. 5; pp. 607 - 610
• Main Authors: Smith-Jackson, K, Hentschke, M.R, Poli-de-Figueiredo, C.E, Pinheiro da Costa, B.E, Kurlak, L.O, Broughton Pipkin, F, Czajka, A, Mistry, H.D
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01-05-2015
• Subjects: Case-Control Studies; Caveolae - metabolism; Caveolin; Caveolin 1 - metabolism; Cavin; Female; Humans; Hypertension; Internal Medicine; Nitric Oxide Synthase Type II - metabolism; Nitric Oxide Synthase Type III - metabolism; Obstetrics and Gynecology; Placenta; Placenta - metabolism; Pre-eclampsia; Pre-Eclampsia - metabolism; Pregnancy; Hypertension; Cavin; Placenta; Pre-eclampsia; Caveolin
• ISSN: 0143-4004; 1532-3102
• DOI: 10.1016/j.placenta.2015.02.001

Abstract Caveolae regulate many cardiovascular functions and thus could be of interest in relation to pre-eclampsia, a pregnancy specific disorder characterised by hypertension and proteinuria. We examined placental mRNA and protein expression/localisation of the caveolae components Caveolin 1-3, Cavin 1-4 as well as eNOS/iNOS in normotensive control (n = 24) and pre-eclamptic pregnancies (n = 19). Placental mRNA expression of caveolin-1 , cavin 1-3 , was lower and eNOS expression was increased in pre-eclampsia ( P  < 0.05 for all). Additionally Caveolin-1 protein expression was also reduced in pre-eclampsia ( P  = 0.007); this could be an adaptive response in pre-eclampsia, possibly to attenuate the oxidative stress/inflammation.