Single dose varenicline may trigger epileptic activity

Varenicline is a new drug for smoking cessation, and its effect on epilepsy is not clear. The aim of this study was to investigate whether different doses of varenicline cause epileptic activity. Forty rats were randomly assigned to the following eight groups: control, saline, and 0.025, 0.04, 0.1,...

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Published in:	Neurological sciences Vol. 35; no. 11; pp. 1807 - 1812
Main Authors:	Erken, Haydar Ali, Erken, Gülten, Şimşek, Hasan, Korkut, Oğuzhan, Koç, Emine Rabia, Yavuz, Özlem, Genç, Osman
Format:	Journal Article
Language:	English
Published:	Milan Springer Milan 01-11-2014 Springer Nature B.V
Subjects:	Animals Benzazepines - administration & dosage Benzazepines - toxicity Brain - drug effects Dose-Response Relationship, Drug Electroencephalography Epilepsy - chemically induced Male Medicine Medicine & Public Health Neurology Neuroradiology Neurosciences Neurosurgery Nicotinic Agonists - administration & dosage Nicotinic Agonists - toxicity Original Article Psychiatry Quinoxalines - administration & dosage Quinoxalines - toxicity Rats Rats, Wistar Seizures - chemically induced Varenicline Seizure Adverse effect EEG Epilepsy Varenicline
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Abstract	Varenicline is a new drug for smoking cessation, and its effect on epilepsy is not clear. The aim of this study was to investigate whether different doses of varenicline cause epileptic activity. Forty rats were randomly assigned to the following eight groups: control, saline, and 0.025, 0.04, 0.1, 0.5, 1, and 2 mg kg −1 varenicline (single dose, i.p.). EEGs were recorded before the varenicline injection and during the following 240 min. While epileptic discharges were observed on the EEGs of the rats in all of the varenicline-treated groups, motor findings of epileptic seizure were not observed in some rats in these groups except the 1 and 2 mg kg −1 groups. These findings indicate that different single doses of varenicline cause epileptic activity in rats.
AbstractList	Varenicline is a new drug for smoking cessation, and its effect on epilepsy is not clear. The aim of this study was to investigate whether different doses of varenicline cause epileptic activity. Forty rats were randomly assigned to the following eight groups: control, saline, and 0.025, 0.04, 0.1, 0.5, 1, and 2 mg kg(-1) varenicline (single dose, i.p.). EEGs were recorded before the varenicline injection and during the following 240 min. While epileptic discharges were observed on the EEGs of the rats in all of the varenicline-treated groups, motor findings of epileptic seizure were not observed in some rats in these groups except the 1 and 2 mg kg(-1) groups. These findings indicate that different single doses of varenicline cause epileptic activity in rats. Varenicline is a new drug for smoking cessation, and its effect on epilepsy is not clear. The aim of this study was to investigate whether different doses of varenicline cause epileptic activity. Forty rats were randomly assigned to the following eight groups: control, saline, and 0.025, 0.04, 0.1, 0.5, 1, and 2 mg kg^sup -1^ varenicline (single dose, i.p.). EEGs were recorded before the varenicline injection and during the following 240 min. While epileptic discharges were observed on the EEGs of the rats in all of the varenicline-treated groups, motor findings of epileptic seizure were not observed in some rats in these groups except the 1 and 2 mg kg^sup -1^ groups. These findings indicate that different single doses of varenicline cause epileptic activity in rats.[PUBLICATION ABSTRACT] Varenicline is a new drug for smoking cessation, and its effect on epilepsy is not clear. The aim of this study was to investigate whether different doses of varenicline cause epileptic activity. Forty rats were randomly assigned to the following eight groups: control, saline, and 0.025, 0.04, 0.1, 0.5, 1, and 2 mg kg −1 varenicline (single dose, i.p.). EEGs were recorded before the varenicline injection and during the following 240 min. While epileptic discharges were observed on the EEGs of the rats in all of the varenicline-treated groups, motor findings of epileptic seizure were not observed in some rats in these groups except the 1 and 2 mg kg −1 groups. These findings indicate that different single doses of varenicline cause epileptic activity in rats. Varenicline is a new drug for smoking cessation, and its effect on epilepsy is not clear. The aim of this study was to investigate whether different doses of varenicline cause epileptic activity. Forty rats were randomly assigned to the following eight groups: control, saline, and 0.025, 0.04, 0.1, 0.5, 1, and 2 mg kg super(-1) varenicline (single dose, i.p.). EEGs were recorded before the varenicline injection and during the following 240 min. While epileptic discharges were observed on the EEGs of the rats in all of the varenicline-treated groups, motor findings of epileptic seizure were not observed in some rats in these groups except the 1 and 2 mg kg super(-1) groups. These findings indicate that different single doses of varenicline cause epileptic activity in rats.
Author	Erken, Haydar Ali Şimşek, Hasan Yavuz, Özlem Genç, Osman Korkut, Oğuzhan Erken, Gülten Koç, Emine Rabia
Author_xml	– sequence: 1 givenname: Haydar Ali surname: Erken fullname: Erken, Haydar Ali email: haerken@yahoo.com organization: Department of Physiology, Faculty of Medicine, Balikesir University – sequence: 2 givenname: Gülten surname: Erken fullname: Erken, Gülten organization: Department of Physiology, Faculty of Medicine, Balikesir University – sequence: 3 givenname: Hasan surname: Şimşek fullname: Şimşek, Hasan organization: Department of Physiology, Faculty of Medicine, Dumlupinar University – sequence: 4 givenname: Oğuzhan surname: Korkut fullname: Korkut, Oğuzhan organization: Department of Pharmacology, Faculty of Medicine, Balikesir University – sequence: 5 givenname: Emine Rabia surname: Koç fullname: Koç, Emine Rabia organization: Department of Neurology, Faculty of Medicine, Balikesir University – sequence: 6 givenname: Özlem surname: Yavuz fullname: Yavuz, Özlem organization: Department of Biochemistry, Faculty of Medicine, Balikesir University – sequence: 7 givenname: Osman surname: Genç fullname: Genç, Osman organization: Department of Physiology, Faculty of Medicine, Dumlupinar University
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/24906297$$D View this record in MEDLINE/PubMed
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CitedBy_id	crossref_primary_10_1016_j_yebeh_2019_05_031 crossref_primary_10_3389_fmolb_2022_860246 crossref_primary_10_1038_s41598_022_05697_8 crossref_primary_10_3390_ijms24032616
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Snippet	Varenicline is a new drug for smoking cessation, and its effect on epilepsy is not clear. The aim of this study was to investigate whether different doses of...
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SubjectTerms	Animals Benzazepines - administration & dosage Benzazepines - toxicity Brain - drug effects Dose-Response Relationship, Drug Electroencephalography Epilepsy - chemically induced Male Medicine Medicine & Public Health Neurology Neuroradiology Neurosciences Neurosurgery Nicotinic Agonists - administration & dosage Nicotinic Agonists - toxicity Original Article Psychiatry Quinoxalines - administration & dosage Quinoxalines - toxicity Rats Rats, Wistar Seizures - chemically induced Varenicline
Title	Single dose varenicline may trigger epileptic activity
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