Experimental and spontaneous metastasis assays can result in divergence in clonal architecture

Intratumoural heterogeneity is associated with poor outcomes in breast cancer. To understand how malignant clones survive and grow in metastatic niches, in vivo models using cell lines and patient-derived xenografts (PDX) have become the gold standard. Injections of cancer cells in orthotopic sites...

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Bibliographic Details
Published in:	Communications biology Vol. 6; no. 1; p. 821
Main Authors:	Serrano, Antonin, Weber, Tom, Berthelet, Jean, El-Saafin, Farrah, Gadipally, Sreeja, Charafe-Jauffret, Emmanuelle, Ginestier, Christophe, Mariadason, John M., Oakes, Samantha R., Britt, Kara, Naik, Shalin H., Merino, Delphine
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 07-08-2023 Nature Publishing Group Nature Portfolio
Subjects:	13 45/44 631/67/2329 631/67/70 64 64/60 96/106 96/31 Bar codes Biology Biomedical and Life Sciences Breast cancer Cell culture Life Sciences Metastases Metastasis
Online Access:	Get full text
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