Multivalent next generation influenza virus vaccines protect against seasonal and pre-pandemic viruses
Each year, new influenza virus vaccine formulations are generated to keep up with continuously circulating and mutating viral variants. A next-generation influenza virus vaccine would provide long-lasting, broadly-reactive immune protection against current and future influenza virus strains for both...
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| Published in: | Scientific reports Vol. 14; no. 1; p. 1440 |
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| Main Authors: | , |
| Format: | Journal Article |
| Language: | English |
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16-01-2024
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| Abstract | Each year, new influenza virus vaccine formulations are generated to keep up with continuously circulating and mutating viral variants. A next-generation influenza virus vaccine would provide long-lasting, broadly-reactive immune protection against current and future influenza virus strains for both seasonal and pre-pandemic viruses. Next generation immunogens were designed using computationally optimized broadly reactive antigen (COBRA) methodology to protect against a broad range of strains over numerous seasons. Novel HA and NA amino acid sequences were derived from multilayered consensus sequence alignment for multiple subtypes of influenza. This multivalent formulation was hypothesized to elicit broadly protective immune responses against both seasonal and pre-pandemic influenza viruses. Mice were vaccinated with multivalent mixtures of HA and NA (H1, H2, H3, H5, H7, N1, N2) proteins. Multivalent COBRA vaccinations elicited antibodies that recognized a broad panel of strains and vaccinated mice were protected against viruses representing multiple subtypes. This is a promising candidate for a universal influenza vaccine that elicits protective immune responses against seasonal and pre-pandemic strains over multiple seasons. |
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| AbstractList | Each year, new influenza virus vaccine formulations are generated to keep up with continuously circulating and mutating viral variants. A next-generation influenza virus vaccine would provide long-lasting, broadly-reactive immune protection against current and future influenza virus strains for both seasonal and pre-pandemic viruses. Next generation immunogens were designed using computationally optimized broadly reactive antigen (COBRA) methodology to protect against a broad range of strains over numerous seasons. Novel HA and NA amino acid sequences were derived from multilayered consensus sequence alignment for multiple subtypes of influenza. This multivalent formulation was hypothesized to elicit broadly protective immune responses against both seasonal and pre-pandemic influenza viruses. Mice were vaccinated with multivalent mixtures of HA and NA (H1, H2, H3, H5, H7, N1, N2) proteins. Multivalent COBRA vaccinations elicited antibodies that recognized a broad panel of strains and vaccinated mice were protected against viruses representing multiple subtypes. This is a promising candidate for a universal influenza vaccine that elicits protective immune responses against seasonal and pre-pandemic strains over multiple seasons. Abstract Each year, new influenza virus vaccine formulations are generated to keep up with continuously circulating and mutating viral variants. A next-generation influenza virus vaccine would provide long-lasting, broadly-reactive immune protection against current and future influenza virus strains for both seasonal and pre-pandemic viruses. Next generation immunogens were designed using computationally optimized broadly reactive antigen (COBRA) methodology to protect against a broad range of strains over numerous seasons. Novel HA and NA amino acid sequences were derived from multilayered consensus sequence alignment for multiple subtypes of influenza. This multivalent formulation was hypothesized to elicit broadly protective immune responses against both seasonal and pre-pandemic influenza viruses. Mice were vaccinated with multivalent mixtures of HA and NA (H1, H2, H3, H5, H7, N1, N2) proteins. Multivalent COBRA vaccinations elicited antibodies that recognized a broad panel of strains and vaccinated mice were protected against viruses representing multiple subtypes. This is a promising candidate for a universal influenza vaccine that elicits protective immune responses against seasonal and pre-pandemic strains over multiple seasons. |
| ArticleNumber | 1440 |
| Author | Uno, Naoko Ross, Ted M. |
| Author_xml | – sequence: 1 givenname: Naoko surname: Uno fullname: Uno, Naoko organization: Center for Vaccines and Immunology, University of Georgia, Department of Infection Biology, Lerner Research Institute, Cleveland Clinic – sequence: 2 givenname: Ted M. surname: Ross fullname: Ross, Ted M. email: rosst7@ccf.org organization: Center for Vaccines and Immunology, University of Georgia, Department of Infectious Diseases, University of Georgia, Florida Research and Innovation Center, Cleveland Clinic Florida, Department of Infection Biology, Lerner Research Institute, Cleveland Clinic |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38228649$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1038/s41467-022-29402-5 10.1371/journal.pbio.3000411 10.1128/JVI.00946-18 10.1128/mBio.00417-16 10.3390/vaccines9040375 10.1046/j.1365-2672.2001.01492.x 10.1093/infdis/jiy103 10.1038/nature14460 10.3390/v10090461 10.1126/science.abm0271 10.1093/infdis/jiy696 10.1093/infdis/jiy633 10.1128/mBio.02284-17 10.2807/1560-7917.ES2015.20.13.21085 10.1016/j.tim.2018.05.013 10.1038/s41598-018-34077-4 10.1128/JVI.00742-20 10.1038/nrmicro.2017.118 10.1093/infdis/jiy711 10.1002/rmv.2099 10.1093/bmb/ldz036 10.3390/vaccines6030046 10.3390/v14102168 10.15585/mmwr.mm7129a1 10.1128/jvi.01526-01518 10.1128/JVI.01526-20 10.1093/infdis/jiz017 10.3390/pathogens5040066 10.3389/fmicb.2019.00039 10.1038/s41577-019-0143-6 10.1073/pnas.1920321117 10.1016/j.cmi.2016.07.007 10.1093/infdis/jiz010 10.1080/22221751.2022.2155072 10.1371/journal.pone.0246613 10.3390/vaccines8030462 10.15585/mmwr.rr6803a1 10.1038/laban1004-50 10.1093/infdis/jiv195 10.1038/s41598-019-51877-4 10.1126/science.abo1232 10.1080/21645515.2018.1462639 10.1038/nrd4529 10.1089/vim.2017.0129 10.1016/j.virol.2016.10.024 10.1038/s41591-019-0463-x 10.1016/j.vaccine.2011.01.100 10.3390/vaccines8030409 10.1038/s41598-023-27446-1 10.1017/S0022172400022610 10.1128/JVI.03152-15 10.1080/22221751.2019.1581034 10.3390/pathogens10111352 10.1128/JVI.00797-19 10.1002/embj.201387442 10.1007/s11684-020-0739-z 10.1016/j.coviro.2011.07.003 10.1007/s12275-017-7062-7 10.1186/1471-2334-14-266 10.1186/s12985-017-0918-y 10.1172/JCI84428 10.1016/j.vaccine.2014.01.078 10.1016/S0140-6736(17)33293-2 10.3390/v6062465 10.3390/vaccines9070793 10.1128/JVI.00759-21 10.1101/cshperspect.a038778 10.1111/j.1750-2659.2011.00304.x 10.1101/2023.02.08.527769 10.1111/irv.12324 10.1177/1178122X18788328 10.15585/mmwr.rr7101a1 10.1007/978-3-540-92165-3_12 10.1101/2022.07.29.501155 10.32942/X26K57 10.1101/2020.05.30.125179 10.1016/j.xinn.2022.100306 10.1007/82_2014_393 |
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| References | Dhanasekaran (CR72) 2022; 13 Giles, Ross (CR14) 2011; 29 de Graaf, Fouchier (CR67) 2014; 33 Ng (CR40) 2019; 25 Zost, Wu, Hensley, Wilson (CR43) 2019; 219 Monto (CR21) 2015; 212 CR79 CR34 Sorrell, Schrauwen, Fouchier (CR68) 2011; 1 CR76 Li, Linster, Mendenhall, Su, Smith (CR58) 2019; 132 Isoda (CR63) 2022; 14 Wille, Barr (CR55) 2022; 376 Lai, Karunarathna, Wong, Peiris, Nicholls (CR31) 2019; 8 CR71 DiLillo, Palese, Wilson, Ravetch (CR45) 2016; 126 Maher, DeStefano (CR78) 2004; 33 McAuley, Gilbertson, Trifkovic, Brown, McKimm-Breschkin (CR49) 2019; 10 Yamaji (CR70) 2020; 30 Dhakal, Klein (CR12) 2019; 93 Giurgea, Morens, Taubenberger, Memoli (CR47) 2020; 8 Chen, Lan, Huang, Henry, Wilson (CR37) 2019; 93 Grohskopf (CR23) 2019; 68 Halder, Kelso, Milne (CR27) 2014; 14 Reneer, Jamieson, Skarlupka, Huang, Ross (CR17) 2020; 95 Iuliano (CR1) 2018; 391 Gaymard, Le Briand, Frobert, Lina, Escuret (CR32) 2016; 22 Park (CR41) 2018; 9 Zheng (CR50) 2020; 94 Jang, Ross (CR80) 2021; 16 Baz (CR38) 2019; 9 Eichelberger, Monto (CR52) 2019; 219 Skarlupka, Bebin-Blackwell, Sumner, Ross (CR19) 2021; 95 CR46 Pando (CR10) 2021; 9 Shi, Zeng, Cui, Yan, Chen (CR64) 2023; 12 Sultana (CR51) 2014; 32 CR84 De Vries, Herfst, Richard (CR11) 2018; 6 Allen (CR18) 2021 Wu, Xiao, Li (CR57) 2020; 14 Sautto, Kirchenbaum, Ross (CR22) 2018; 15 Allen, Ross (CR83) 2018; 14 Krammer, Palese (CR5) 2015; 14 Sutton (CR54) 2018; 10 Carter (CR33) 2016; 90 Paules, Fauci (CR26) 2019; 219 CR56 Air (CR30) 2012; 6 Du Sert (CR82) 2020; 18 Hsieh (CR9) 2018; 8 Bedford (CR77) 2015; 523 Erbelding (CR13) 2018; 218 Allen, Jang, DiNapoli, Kleanthous, Ross (CR85) 2019; 93 Arafa (CR69) 2015; 20 Skarlupka (CR35) 2022 Nuñez, Huang, Ross (CR16) 2021; 10 Arevalo (CR3) 2020; 117 Altman, Angeletti, Yewdell (CR25) 2018; 31 Sautto, Ross (CR74) 2019; 55 Kosik, Yewdell (CR36) 2017; 500 Nemeth (CR62) 2023; 13 Saunders-Hastings, Krewski (CR7) 2016; 5 Merced-Morales (CR8) 2022; 71 CR28 Jang, Bae (CR53) 2018; 9 Wu, Wilson (CR29) 2020; 10 Hobson, Curry, Beare, Ward-Gardner (CR39) 1972; 70 Krammer (CR4) 2019; 19 CR24 Memoli (CR20) 2016; 7 CR66 CR65 Harfoot, Webby (CR59) 2017; 55 Ecker (CR81) 2020; 8 Petrova, Russell (CR73) 2018; 16 Potter (CR6) 2001; 91 Hutchinson (CR2) 2018; 26 CR61 Krammer, Palese (CR42) 2019; 219 CR60 Crowe (CR44) 2019; 219 Huang, França, Allen, Shi, Ross (CR15) 2021; 9 Wohlbold, Krammer (CR48) 2014; 6 Arevalo (CR75) 2022; 378 JD Allen (51024_CR18) 2021 JCC Lai (51024_CR31) 2019; 8 J Shi (51024_CR64) 2023; 12 H Jang (51024_CR80) 2021; 16 S Ng (51024_CR40) 2019; 25 NC Wu (51024_CR29) 2020; 10 51024_CR56 SJ Zost (51024_CR43) 2019; 219 Y Huang (51024_CR15) 2021; 9 I Kosik (51024_CR36) 2017; 500 M de Graaf (51024_CR67) 2014; 33 A Zheng (51024_CR50) 2020; 94 F Krammer (51024_CR42) 2019; 219 EJ Erbelding (51024_CR13) 2018; 218 BM Giles (51024_CR14) 2011; 29 X Wu (51024_CR57) 2020; 14 N Isoda (51024_CR63) 2022; 14 V Dhanasekaran (51024_CR72) 2022; 13 CW Potter (51024_CR6) 2001; 91 DJ DiLillo (51024_CR45) 2016; 126 J Jang (51024_CR53) 2018; 9 Y-T Li (51024_CR58) 2019; 132 GA Sautto (51024_CR74) 2019; 55 AD Iuliano (51024_CR1) 2018; 391 NP Du Sert (51024_CR82) 2020; 18 51024_CR65 CP Arevalo (51024_CR3) 2020; 117 D Hobson (51024_CR39) 1972; 70 DM Carter (51024_CR33) 2016; 90 51024_CR60 51024_CR61 JA Maher (51024_CR78) 2004; 33 51024_CR28 A Merced-Morales (51024_CR8) 2022; 71 51024_CR66 51024_CR24 I Sultana (51024_CR51) 2014; 32 S Dhakal (51024_CR12) 2019; 93 R Pando (51024_CR10) 2021; 9 MO Altman (51024_CR25) 2018; 31 TJ Wohlbold (51024_CR48) 2014; 6 M Wille (51024_CR55) 2022; 376 JD Allen (51024_CR83) 2018; 14 F Krammer (51024_CR5) 2015; 14 R Yamaji (51024_CR70) 2020; 30 EC Hutchinson (51024_CR2) 2018; 26 TC Sutton (51024_CR54) 2018; 10 AS Monto (51024_CR21) 2015; 212 51024_CR76 R Harfoot (51024_CR59) 2017; 55 51024_CR71 M Baz (51024_CR38) 2019; 9 51024_CR34 51024_CR79 LA Grohskopf (51024_CR23) 2019; 68 PR Saunders-Hastings (51024_CR7) 2016; 5 F Krammer (51024_CR4) 2019; 19 A Gaymard (51024_CR32) 2016; 22 JW Ecker (51024_CR81) 2020; 8 RD De Vries (51024_CR11) 2018; 6 A Arafa (51024_CR69) 2015; 20 T Bedford (51024_CR77) 2015; 523 JL McAuley (51024_CR49) 2019; 10 J-K Park (51024_CR41) 2018; 9 51024_CR84 E Sorrell (51024_CR68) 2011; 1 ZB Reneer (51024_CR17) 2020; 95 Y-Q Chen (51024_CR37) 2019; 93 IA Nuñez (51024_CR16) 2021; 10 CI Paules (51024_CR26) 2019; 219 N Halder (51024_CR27) 2014; 14 GM Air (51024_CR30) 2012; 6 MJ Memoli (51024_CR20) 2016; 7 AL Skarlupka (51024_CR19) 2021; 95 A Skarlupka (51024_CR35) 2022 LT Giurgea (51024_CR47) 2020; 8 MC Eichelberger (51024_CR52) 2019; 219 51024_CR46 Y-C Hsieh (51024_CR9) 2018; 8 JD Allen (51024_CR85) 2019; 93 GA Sautto (51024_CR22) 2018; 15 VN Petrova (51024_CR73) 2018; 16 CP Arevalo (51024_CR75) 2022; 378 JE Crowe Jr (51024_CR44) 2019; 219 NM Nemeth (51024_CR62) 2023; 13 |
| References_xml | – volume: 13 start-page: 1721 year: 2022 ident: CR72 article-title: Human seasonal influenza under COVID-19 and the potential consequences of influenza lineage elimination publication-title: Nat. Commun. doi: 10.1038/s41467-022-29402-5 contributor: fullname: Dhanasekaran – volume: 18 start-page: e3000411 year: 2020 ident: CR82 article-title: Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 20 publication-title: PLOS Biol. doi: 10.1371/journal.pbio.3000411 contributor: fullname: Du Sert – volume: 93 start-page: 10 year: 2019 end-page: 1128 ident: CR85 article-title: Elicitation of protective antibodies against 20 years of future H3N2 cocirculating influenza virus variants in ferrets preimmune to historical H3N2 influenza viruses publication-title: J. Virol. doi: 10.1128/JVI.00946-18 contributor: fullname: Ross – volume: 7 start-page: 10 year: 2016 end-page: 1128 ident: CR20 article-title: Evaluation of antihemagglutinin and antineuraminidase antibodies as correlates of protection in an influenza A/H1N1 virus healthy human challenge model publication-title: MBio doi: 10.1128/mBio.00417-16 contributor: fullname: Memoli – volume: 9 start-page: 375 year: 2021 ident: CR10 article-title: Diversity in the circulation of influenza A (H3N2) viruses in the northern hemisphere in the 2018–19 season publication-title: Vaccines doi: 10.3390/vaccines9040375 contributor: fullname: Pando – volume: 91 start-page: 572 year: 2001 end-page: 579 ident: CR6 article-title: A history of influenza publication-title: J. Appl. Microbiol. doi: 10.1046/j.1365-2672.2001.01492.x contributor: fullname: Potter – volume: 218 start-page: 347 year: 2018 end-page: 354 ident: CR13 article-title: A universal influenza vaccine: The strategic plan for the National Institute of Allergy and Infectious Diseases publication-title: J. Infect. Dis. doi: 10.1093/infdis/jiy103 contributor: fullname: Erbelding – ident: CR61 – volume: 523 start-page: 217 year: 2015 end-page: 220 ident: CR77 article-title: Global circulation patterns of seasonal influenza viruses vary with antigenic drift publication-title: Nature doi: 10.1038/nature14460 contributor: fullname: Bedford – ident: CR84 – volume: 10 start-page: 461 year: 2018 ident: CR54 article-title: The pandemic threat of emerging H5 and H7 avian influenza viruses publication-title: Viruses doi: 10.3390/v10090461 contributor: fullname: Sutton – volume: 378 start-page: 899 year: 2022 end-page: 904 ident: CR75 article-title: A multivalent nucleoside-modified mRNA vaccine against all known influenza virus subtypes publication-title: Science doi: 10.1126/science.abm0271 contributor: fullname: Arevalo – year: 2022 ident: CR35 publication-title: Broadly Reactive Influenza Neuraminidase-Specific Antibody Mediated Protection in the Mouse and Ferret Animal Models contributor: fullname: Skarlupka – volume: 219 start-page: S38 year: 2019 end-page: S45 ident: CR43 article-title: Immunodominance and antigenic variation of influenza virus hemagglutinin: Implications for design of universal vaccine immunogens publication-title: J. Infect. Dis. doi: 10.1093/infdis/jiy696 contributor: fullname: Wilson – volume: 219 start-page: S1 year: 2019 end-page: S4 ident: CR26 article-title: Influenza vaccines: Good, but we can do better publication-title: J. Infect. Dis. doi: 10.1093/infdis/jiy633 contributor: fullname: Fauci – volume: 9 start-page: 10 year: 2018 end-page: 1128 ident: CR41 article-title: Evaluation of preexisting anti-hemagglutinin stalk antibody as a correlate of protection in a healthy volunteer challenge with influenza A/H1N1pdm virus publication-title: MBio doi: 10.1128/mBio.02284-17 contributor: fullname: Park – volume: 20 start-page: 21085 year: 2015 ident: CR69 article-title: Emergence of a novel cluster of influenza A (H5N1) virus clade 2.2 1.2 with putative human health impact in Egypt, 2014/15 publication-title: Eurosurveillance doi: 10.2807/1560-7917.ES2015.20.13.21085 contributor: fullname: Arafa – year: 2021 ident: CR18 publication-title: Design and Characterization of Computationally Optimized Broadly Reactive Antigen (Cobra) Vaccines Against Human Seasonal Influenza A (H3N2) Viruses contributor: fullname: Allen – ident: CR46 – ident: CR71 – volume: 26 start-page: 809 year: 2018 end-page: 810 ident: CR2 article-title: Influenza virus publication-title: Trends Microbiol. doi: 10.1016/j.tim.2018.05.013 contributor: fullname: Hutchinson – volume: 8 start-page: 1 year: 2018 end-page: 10 ident: CR9 article-title: Clinical characteristics of patients with laboratory-confirmed influenza A (H1N1) pdm09 during the 2013/2014 and 2015/2016 clade 6B/6B. 1/6B. 2-predominant outbreaks publication-title: Sci. Rep. doi: 10.1038/s41598-018-34077-4 contributor: fullname: Hsieh – volume: 94 start-page: 10 year: 2020 end-page: 1128 ident: CR50 article-title: Enhancing neuraminidase immunogenicity of influenza A viruses by rewiring RNA packaging signals publication-title: J. Virol. doi: 10.1128/JVI.00742-20 contributor: fullname: Zheng – volume: 16 start-page: 47 year: 2018 end-page: 60 ident: CR73 article-title: The evolution of seasonal influenza viruses publication-title: Nat. Rev. Microbiol. doi: 10.1038/nrmicro.2017.118 contributor: fullname: Russell – volume: 219 start-page: S62 year: 2019 end-page: S67 ident: CR42 article-title: Universal influenza virus vaccines that target the conserved hemagglutinin stalk and conserved sites in the head domain publication-title: J. Infect. Dis. doi: 10.1093/infdis/jiy711 contributor: fullname: Palese – volume: 30 start-page: e2099 year: 2020 ident: CR70 article-title: Pandemic potential of highly pathogenic avian influenza clade 23 44 A (H5) viruses publication-title: Rev. Med. Virol. doi: 10.1002/rmv.2099 contributor: fullname: Yamaji – volume: 132 start-page: 81 year: 2019 end-page: 95 ident: CR58 article-title: Avian influenza viruses in humans: Lessons from past outbreaks publication-title: Br. Med. Bull. doi: 10.1093/bmb/ldz036 contributor: fullname: Smith – volume: 6 start-page: 46 year: 2018 ident: CR11 article-title: Avian influenza A virus pandemic preparedness and vaccine development publication-title: Vaccines doi: 10.3390/vaccines6030046 contributor: fullname: Richard – volume: 14 start-page: 2168 year: 2022 ident: CR63 article-title: Detection of new H5N1 high pathogenicity avian influenza viruses in winter 2021–2022 in the far east, which are genetically close to those in Europe publication-title: Viruses doi: 10.3390/v14102168 contributor: fullname: Isoda – volume: 71 start-page: 913 year: 2022 ident: CR8 article-title: Influenza activity and composition of the 2022–23 influenza vaccine—United States, 2021–22 season publication-title: Morb. Mortal. Wkly. Rep. doi: 10.15585/mmwr.mm7129a1 contributor: fullname: Merced-Morales – volume: 93 start-page: 10 year: 2019 end-page: 1128 ident: CR37 article-title: Hemagglutinin stalk-reactive antibodies interfere with influenza virus neuraminidase activity by steric hindrance publication-title: J. Virol. doi: 10.1128/jvi.01526-01518 contributor: fullname: Wilson – volume: 95 start-page: e01526 year: 2020 end-page: e1520 ident: CR17 article-title: Computationally optimized broadly reactive H2 HA influenza vaccines elicited broadly cross-reactive antibodies and protected mice from viral challenges publication-title: J. Virol. doi: 10.1128/JVI.01526-20 contributor: fullname: Ross – volume: 219 start-page: S75 year: 2019 end-page: S80 ident: CR52 article-title: Neuraminidase, the forgotten surface antigen, emerges as an influenza vaccine target for broadened protection publication-title: J. Infect. Dis. doi: 10.1093/infdis/jiz017 contributor: fullname: Monto – volume: 9 start-page: 1178122X18788328 year: 2018 ident: CR53 article-title: Comparative co-evolution analysis between the HA and NA genes of influenza A virus publication-title: Virol. Res. Treat. contributor: fullname: Bae – ident: CR60 – volume: 5 start-page: 66 year: 2016 ident: CR7 article-title: Reviewing the history of pandemic influenza: Understanding patterns of emergence and transmission publication-title: Pathogens doi: 10.3390/pathogens5040066 contributor: fullname: Krewski – volume: 10 start-page: 39 year: 2019 ident: CR49 article-title: Influenza virus neuraminidase structure and functions publication-title: Front. Microbiol. doi: 10.3389/fmicb.2019.00039 contributor: fullname: McKimm-Breschkin – volume: 19 start-page: 383 year: 2019 end-page: 397 ident: CR4 article-title: The human antibody response to influenza A virus infection and vaccination publication-title: Nat. Rev. Immunol. doi: 10.1038/s41577-019-0143-6 contributor: fullname: Krammer – volume: 117 start-page: 17221 year: 2020 end-page: 17227 ident: CR3 article-title: Original antigenic sin priming of influenza virus hemagglutinin stalk antibodies publication-title: Proc. Natl. Acad. Sci. doi: 10.1073/pnas.1920321117 contributor: fullname: Arevalo – volume: 22 start-page: 975 year: 2016 end-page: 983 ident: CR32 article-title: Functional balance between neuraminidase and haemagglutinin in influenza viruses publication-title: Clin. Microbiol. Infect. doi: 10.1016/j.cmi.2016.07.007 contributor: fullname: Escuret – volume: 219 start-page: S21 year: 2019 end-page: S29 ident: CR44 article-title: Antibody determinants of influenza immunity publication-title: J. Infect. Dis. doi: 10.1093/infdis/jiz010 contributor: fullname: Crowe – volume: 12 start-page: 2155072 year: 2023 ident: CR64 article-title: Alarming situation of emerging H5 and H7 avian influenza and effective control strategies publication-title: Emerg. Microb. Infect. doi: 10.1080/22221751.2022.2155072 contributor: fullname: Chen – volume: 16 start-page: e0246613 year: 2021 ident: CR80 article-title: Hemagglutination inhibition (HAI) antibody landscapes after vaccination with H7Nx virus like particles publication-title: PLOS ONE doi: 10.1371/journal.pone.0246613 contributor: fullname: Ross – volume: 8 start-page: 462 year: 2020 ident: CR81 article-title: High-yield expression and purification of recombinant influenza virus proteins from stably-transfected mammalian cell lines publication-title: Vaccines doi: 10.3390/vaccines8030462 contributor: fullname: Ecker – volume: 68 start-page: 1 year: 2019 ident: CR23 article-title: Prevention and control of seasonal influenza with vaccines: Recommendations of the Advisory Committee on Immunization Practices—United States, 2019–20 influenza season publication-title: MMWR Recomm. Rep. doi: 10.15585/mmwr.rr6803a1 contributor: fullname: Grohskopf – volume: 33 start-page: 50 year: 2004 end-page: 53 ident: CR78 article-title: The ferret: An animal model to study influenza virus publication-title: Lab Anim. doi: 10.1038/laban1004-50 contributor: fullname: DeStefano – volume: 212 start-page: 1191 year: 2015 end-page: 1199 ident: CR21 article-title: Antibody to influenza virus neuraminidase: An independent correlate of protection publication-title: J. Infect. Dis. doi: 10.1093/infdis/jiv195 contributor: fullname: Monto – ident: CR66 – volume: 9 start-page: 1 year: 2019 end-page: 14 ident: CR38 article-title: Synergistic PA and HA mutations confer mouse adaptation of a contemporary A/H3N2 influenza virus publication-title: Sci. Rep. doi: 10.1038/s41598-019-51877-4 contributor: fullname: Baz – volume: 376 start-page: 459 year: 2022 end-page: 460 ident: CR55 article-title: Resurgence of avian influenza virus publication-title: Science doi: 10.1126/science.abo1232 contributor: fullname: Barr – volume: 14 start-page: 1840 year: 2018 end-page: 1847 ident: CR83 article-title: H3N2 influenza viruses in humans: Viral mechanisms, evolution, and evaluation publication-title: Hum. Vaccin. Immunother. doi: 10.1080/21645515.2018.1462639 contributor: fullname: Ross – volume: 14 start-page: 167 year: 2015 end-page: 182 ident: CR5 article-title: Advances in the development of influenza virus vaccines publication-title: Nat. Rev. Drug Discov. doi: 10.1038/nrd4529 contributor: fullname: Palese – volume: 31 start-page: 142 year: 2018 end-page: 149 ident: CR25 article-title: Antibody immunodominance: The key to understanding influenza virus antigenic drift publication-title: Viral Immunol. doi: 10.1089/vim.2017.0129 contributor: fullname: Yewdell – volume: 500 start-page: 178 year: 2017 end-page: 183 ident: CR36 article-title: Influenza A virus hemagglutinin specific antibodies interfere with virion neuraminidase activity via two distinct mechanisms publication-title: Virology doi: 10.1016/j.virol.2016.10.024 contributor: fullname: Yewdell – volume: 25 start-page: 962 year: 2019 end-page: 967 ident: CR40 article-title: Novel correlates of protection against pandemic H1N1 influenza A virus infection publication-title: Nat. Med. doi: 10.1038/s41591-019-0463-x contributor: fullname: Ng – ident: CR79 – ident: CR56 – volume: 29 start-page: 3043 year: 2011 end-page: 3054 ident: CR14 article-title: A computationally optimized broadly reactive antigen (COBRA) based H5N1 VLP vaccine elicits broadly reactive antibodies in mice and ferrets publication-title: Vaccine doi: 10.1016/j.vaccine.2011.01.100 contributor: fullname: Ross – volume: 8 start-page: 409 year: 2020 ident: CR47 article-title: Influenza neuraminidase: A neglected protein and its potential for a better influenza vaccine publication-title: Vaccines doi: 10.3390/vaccines8030409 contributor: fullname: Memoli – volume: 13 start-page: 191 year: 2023 ident: CR62 article-title: Bald eagle mortality and nest failure due to clade 2.3 4.4 highly pathogenic H5N1 influenza a virus publication-title: Sci. Rep. doi: 10.1038/s41598-023-27446-1 contributor: fullname: Nemeth – volume: 70 start-page: 767 year: 1972 end-page: 777 ident: CR39 article-title: The role of serum haemagglutination-inhibiting antibody in protection against challenge infection with influenza A2 and B viruses publication-title: Epidemiol. Infect. doi: 10.1017/S0022172400022610 contributor: fullname: Ward-Gardner – volume: 90 start-page: 4720 year: 2016 end-page: 4734 ident: CR33 article-title: Design and characterization of a computationally optimized broadly reactive hemagglutinin vaccine for H1N1 influenza viruses publication-title: J. Virol. doi: 10.1128/JVI.03152-15 contributor: fullname: Carter – volume: 8 start-page: 327 year: 2019 end-page: 338 ident: CR31 article-title: Neuraminidase activity and specificity of influenza A virus are influenced by haemagglutinin-receptor binding publication-title: Emerg. Microbes Infect. doi: 10.1080/22221751.2019.1581034 contributor: fullname: Nicholls – volume: 10 start-page: 1352 year: 2021 ident: CR16 article-title: Next-generation computationally designed influenza hemagglutinin vaccines protect against H5Nx virus infections publication-title: Pathogens doi: 10.3390/pathogens10111352 contributor: fullname: Ross – volume: 93 start-page: 10 year: 2019 end-page: 1128 ident: CR12 article-title: Host factors impact vaccine efficacy: Implications for seasonal and universal influenza vaccine programs publication-title: Journal of virology doi: 10.1128/JVI.00797-19 contributor: fullname: Klein – volume: 33 start-page: 823 year: 2014 end-page: 841 ident: CR67 article-title: Role of receptor binding specificity in influenza A virus transmission and pathogenesis publication-title: EMBO J. doi: 10.1002/embj.201387442 contributor: fullname: Fouchier – ident: CR65 – volume: 14 start-page: 8 year: 2020 end-page: 20 ident: CR57 article-title: Research progress on human infection with avian influenza H7N9 publication-title: Front. Med. doi: 10.1007/s11684-020-0739-z contributor: fullname: Li – volume: 1 start-page: 635 year: 2011 end-page: 642 ident: CR68 article-title: Predicting ‘airborne’influenza viruses:(trans-) mission impossible? publication-title: Curr. Opin. Virol. doi: 10.1016/j.coviro.2011.07.003 contributor: fullname: Fouchier – volume: 55 start-page: 196 year: 2017 end-page: 203 ident: CR59 article-title: H5 influenza, a global update publication-title: J. Microbiol. doi: 10.1007/s12275-017-7062-7 contributor: fullname: Webby – volume: 14 start-page: 1 year: 2014 end-page: 19 ident: CR27 article-title: A model-based economic analysis of pre-pandemic influenza vaccination cost-effectiveness publication-title: BMC Infect. Dis. doi: 10.1186/1471-2334-14-266 contributor: fullname: Milne – volume: 15 start-page: 1 year: 2018 end-page: 12 ident: CR22 article-title: Towards a universal influenza vaccine: Different approaches for one goal publication-title: Virol. J. doi: 10.1186/s12985-017-0918-y contributor: fullname: Ross – volume: 126 start-page: 605 year: 2016 end-page: 610 ident: CR45 article-title: Broadly neutralizing anti-influenza antibodies require Fc receptor engagement for in vivo protection publication-title: J. Clin. Investig. doi: 10.1172/JCI84428 contributor: fullname: Ravetch – volume: 55 start-page: 195 year: 2019 end-page: 201 ident: CR74 article-title: Hemagglutinin consensus-based prophylactic approaches to overcome influenza virus diversity publication-title: Veterinaria italiana contributor: fullname: Ross – ident: CR34 – volume: 32 start-page: 2225 year: 2014 end-page: 2230 ident: CR51 article-title: Stability of neuraminidase in inactivated influenza vaccines publication-title: Vaccine doi: 10.1016/j.vaccine.2014.01.078 contributor: fullname: Sultana – volume: 391 start-page: 1285 year: 2018 end-page: 1300 ident: CR1 article-title: Estimates of global seasonal influenza-associated respiratory mortality: A modelling study publication-title: Lancet. doi: 10.1016/S0140-6736(17)33293-2 contributor: fullname: Iuliano – volume: 6 start-page: 2465 year: 2014 end-page: 2494 ident: CR48 article-title: In the shadow of hemagglutinin: A growing interest in influenza viral neuraminidase and its role as a vaccine antigen publication-title: Viruses doi: 10.3390/v6062465 contributor: fullname: Krammer – ident: CR76 – volume: 9 start-page: 793 year: 2021 ident: CR15 article-title: Next generation of computationally optimized broadly reactive ha vaccines elicited cross-reactive immune responses and provided protection against H1N1 virus infection publication-title: Vaccines doi: 10.3390/vaccines9070793 contributor: fullname: Ross – ident: CR28 – volume: 95 start-page: 10 year: 2021 end-page: 1128 ident: CR19 article-title: Universal influenza virus neuraminidase vaccine elicits protective immune responses against human seasonal and pre-pandemic strains publication-title: J. Virol. doi: 10.1128/JVI.00759-21 contributor: fullname: Ross – ident: CR24 – volume: 10 start-page: a038778 year: 2020 ident: CR29 article-title: Influenza hemagglutinin structures and antibody recognition publication-title: Cold Spring Harbor Perspect. Med. doi: 10.1101/cshperspect.a038778 contributor: fullname: Wilson – volume: 6 start-page: 245 year: 2012 ident: CR30 article-title: Influenza neuraminidase publication-title: Influenza Other Respir. Virus. doi: 10.1111/j.1750-2659.2011.00304.x contributor: fullname: Air – volume: 9 start-page: 375 year: 2021 ident: 51024_CR10 publication-title: Vaccines doi: 10.3390/vaccines9040375 contributor: fullname: R Pando – volume: 8 start-page: 409 year: 2020 ident: 51024_CR47 publication-title: Vaccines doi: 10.3390/vaccines8030409 contributor: fullname: LT Giurgea – volume: 94 start-page: 10 year: 2020 ident: 51024_CR50 publication-title: J. Virol. doi: 10.1128/JVI.00742-20 contributor: fullname: A Zheng – ident: 51024_CR61 doi: 10.1101/2023.02.08.527769 – volume: 10 start-page: 39 year: 2019 ident: 51024_CR49 publication-title: Front. Microbiol. doi: 10.3389/fmicb.2019.00039 contributor: fullname: JL McAuley – volume: 70 start-page: 767 year: 1972 ident: 51024_CR39 publication-title: Epidemiol. Infect. doi: 10.1017/S0022172400022610 contributor: fullname: D Hobson – volume: 93 start-page: 10 year: 2019 ident: 51024_CR12 publication-title: Journal of virology doi: 10.1128/JVI.00797-19 contributor: fullname: S Dhakal – volume: 1 start-page: 635 year: 2011 ident: 51024_CR68 publication-title: Curr. Opin. Virol. doi: 10.1016/j.coviro.2011.07.003 contributor: fullname: E Sorrell – volume: 5 start-page: 66 year: 2016 ident: 51024_CR7 publication-title: Pathogens doi: 10.3390/pathogens5040066 contributor: fullname: PR Saunders-Hastings – ident: 51024_CR60 doi: 10.1111/irv.12324 – volume: 8 start-page: 1 year: 2018 ident: 51024_CR9 publication-title: Sci. Rep. doi: 10.1038/s41598-018-34077-4 contributor: fullname: Y-C Hsieh – volume: 9 start-page: 1178122X1878832 year: 2018 ident: 51024_CR53 publication-title: Virol. Res. Treat. doi: 10.1177/1178122X18788328 contributor: fullname: J Jang – volume: 132 start-page: 81 year: 2019 ident: 51024_CR58 publication-title: Br. Med. Bull. doi: 10.1093/bmb/ldz036 contributor: fullname: Y-T Li – volume: 30 start-page: e2099 year: 2020 ident: 51024_CR70 publication-title: Rev. Med. Virol. doi: 10.1002/rmv.2099 contributor: fullname: R Yamaji – volume: 378 start-page: 899 year: 2022 ident: 51024_CR75 publication-title: Science doi: 10.1126/science.abm0271 contributor: fullname: CP Arevalo – volume: 20 start-page: 21085 year: 2015 ident: 51024_CR69 publication-title: Eurosurveillance doi: 10.2807/1560-7917.ES2015.20.13.21085 contributor: fullname: A Arafa – volume: 14 start-page: 1 year: 2014 ident: 51024_CR27 publication-title: BMC Infect. Dis. doi: 10.1186/1471-2334-14-266 contributor: fullname: N Halder – volume: 55 start-page: 195 year: 2019 ident: 51024_CR74 publication-title: Veterinaria italiana contributor: fullname: GA Sautto – volume: 14 start-page: 2168 year: 2022 ident: 51024_CR63 publication-title: Viruses doi: 10.3390/v14102168 contributor: fullname: N Isoda – volume: 10 start-page: 1352 year: 2021 ident: 51024_CR16 publication-title: Pathogens doi: 10.3390/pathogens10111352 contributor: fullname: IA Nuñez – ident: 51024_CR71 – ident: 51024_CR24 doi: 10.15585/mmwr.rr7101a1 – volume: 12 start-page: 2155072 year: 2023 ident: 51024_CR64 publication-title: Emerg. Microb. Infect. doi: 10.1080/22221751.2022.2155072 contributor: fullname: J Shi – volume: 13 start-page: 1721 year: 2022 ident: 51024_CR72 publication-title: Nat. Commun. doi: 10.1038/s41467-022-29402-5 contributor: fullname: V Dhanasekaran – volume: 6 start-page: 245 year: 2012 ident: 51024_CR30 publication-title: Influenza Other Respir. Virus. doi: 10.1111/j.1750-2659.2011.00304.x contributor: fullname: GM Air – volume: 16 start-page: 47 year: 2018 ident: 51024_CR73 publication-title: Nat. Rev. Microbiol. doi: 10.1038/nrmicro.2017.118 contributor: fullname: VN Petrova – volume: 218 start-page: 347 year: 2018 ident: 51024_CR13 publication-title: J. Infect. Dis. doi: 10.1093/infdis/jiy103 contributor: fullname: EJ Erbelding – volume: 219 start-page: S62 year: 2019 ident: 51024_CR42 publication-title: J. Infect. Dis. doi: 10.1093/infdis/jiy711 contributor: fullname: F Krammer – volume: 25 start-page: 962 year: 2019 ident: 51024_CR40 publication-title: Nat. Med. doi: 10.1038/s41591-019-0463-x contributor: fullname: S Ng – volume: 93 start-page: 10 year: 2019 ident: 51024_CR37 publication-title: J. Virol. doi: 10.1128/jvi.01526-01518 contributor: fullname: Y-Q Chen – volume: 9 start-page: 1 year: 2019 ident: 51024_CR38 publication-title: Sci. Rep. doi: 10.1038/s41598-019-51877-4 contributor: fullname: M Baz – volume: 500 start-page: 178 year: 2017 ident: 51024_CR36 publication-title: Virology doi: 10.1016/j.virol.2016.10.024 contributor: fullname: I Kosik – ident: 51024_CR46 doi: 10.1007/978-3-540-92165-3_12 – ident: 51024_CR79 – volume: 391 start-page: 1285 year: 2018 ident: 51024_CR1 publication-title: Lancet. doi: 10.1016/S0140-6736(17)33293-2 contributor: fullname: AD Iuliano – volume: 9 start-page: 10 year: 2018 ident: 51024_CR41 publication-title: MBio doi: 10.1128/mBio.02284-17 contributor: fullname: J-K Park – volume: 219 start-page: S1 year: 2019 ident: 51024_CR26 publication-title: J. Infect. Dis. doi: 10.1093/infdis/jiy633 contributor: fullname: CI Paules – volume: 68 start-page: 1 year: 2019 ident: 51024_CR23 publication-title: MMWR Recomm. Rep. doi: 10.15585/mmwr.rr6803a1 contributor: fullname: LA Grohskopf – volume: 16 start-page: e0246613 year: 2021 ident: 51024_CR80 publication-title: PLOS ONE doi: 10.1371/journal.pone.0246613 contributor: fullname: H Jang – volume: 55 start-page: 196 year: 2017 ident: 51024_CR59 publication-title: J. Microbiol. doi: 10.1007/s12275-017-7062-7 contributor: fullname: R Harfoot – volume: 18 start-page: e3000411 year: 2020 ident: 51024_CR82 publication-title: PLOS Biol. doi: 10.1371/journal.pbio.3000411 contributor: fullname: NP Du Sert – volume: 8 start-page: 327 year: 2019 ident: 51024_CR31 publication-title: Emerg. Microbes Infect. doi: 10.1080/22221751.2019.1581034 contributor: fullname: JCC Lai – volume: 14 start-page: 167 year: 2015 ident: 51024_CR5 publication-title: Nat. Rev. Drug Discov. doi: 10.1038/nrd4529 contributor: fullname: F Krammer – ident: 51024_CR66 doi: 10.1101/2022.07.29.501155 – volume: 8 start-page: 462 year: 2020 ident: 51024_CR81 publication-title: Vaccines doi: 10.3390/vaccines8030462 contributor: fullname: JW Ecker – volume: 117 start-page: 17221 year: 2020 ident: 51024_CR3 publication-title: Proc. Natl. Acad. Sci. doi: 10.1073/pnas.1920321117 contributor: fullname: CP Arevalo – volume: 95 start-page: 10 year: 2021 ident: 51024_CR19 publication-title: J. Virol. doi: 10.1128/JVI.00759-21 contributor: fullname: AL Skarlupka – volume: 32 start-page: 2225 year: 2014 ident: 51024_CR51 publication-title: Vaccine doi: 10.1016/j.vaccine.2014.01.078 contributor: fullname: I Sultana – volume: 90 start-page: 4720 year: 2016 ident: 51024_CR33 publication-title: J. Virol. doi: 10.1128/JVI.03152-15 contributor: fullname: DM Carter – volume: 212 start-page: 1191 year: 2015 ident: 51024_CR21 publication-title: J. Infect. Dis. doi: 10.1093/infdis/jiv195 contributor: fullname: AS Monto – volume: 10 start-page: 461 year: 2018 ident: 51024_CR54 publication-title: Viruses doi: 10.3390/v10090461 contributor: fullname: TC Sutton – volume: 376 start-page: 459 year: 2022 ident: 51024_CR55 publication-title: Science doi: 10.1126/science.abo1232 contributor: fullname: M Wille – ident: 51024_CR65 doi: 10.32942/X26K57 – volume: 126 start-page: 605 year: 2016 ident: 51024_CR45 publication-title: J. Clin. Investig. doi: 10.1172/JCI84428 contributor: fullname: DJ DiLillo – volume: 14 start-page: 1840 year: 2018 ident: 51024_CR83 publication-title: Hum. Vaccin. Immunother. doi: 10.1080/21645515.2018.1462639 contributor: fullname: JD Allen – volume: 91 start-page: 572 year: 2001 ident: 51024_CR6 publication-title: J. Appl. Microbiol. doi: 10.1046/j.1365-2672.2001.01492.x contributor: fullname: CW Potter – ident: 51024_CR76 doi: 10.1101/2020.05.30.125179 – volume: 13 start-page: 191 year: 2023 ident: 51024_CR62 publication-title: Sci. Rep. doi: 10.1038/s41598-023-27446-1 contributor: fullname: NM Nemeth – volume: 7 start-page: 10 year: 2016 ident: 51024_CR20 publication-title: MBio doi: 10.1128/mBio.00417-16 contributor: fullname: MJ Memoli – volume: 22 start-page: 975 year: 2016 ident: 51024_CR32 publication-title: Clin. Microbiol. Infect. doi: 10.1016/j.cmi.2016.07.007 contributor: fullname: A Gaymard – ident: 51024_CR56 – volume: 33 start-page: 823 year: 2014 ident: 51024_CR67 publication-title: EMBO J. doi: 10.1002/embj.201387442 contributor: fullname: M de Graaf – volume: 15 start-page: 1 year: 2018 ident: 51024_CR22 publication-title: Virol. J. doi: 10.1186/s12985-017-0918-y contributor: fullname: GA Sautto – volume: 31 start-page: 142 year: 2018 ident: 51024_CR25 publication-title: Viral Immunol. doi: 10.1089/vim.2017.0129 contributor: fullname: MO Altman – volume: 523 start-page: 217 year: 2015 ident: 51024_CR77 publication-title: Nature doi: 10.1038/nature14460 contributor: fullname: T Bedford – volume: 29 start-page: 3043 year: 2011 ident: 51024_CR14 publication-title: Vaccine doi: 10.1016/j.vaccine.2011.01.100 contributor: fullname: BM Giles – volume: 219 start-page: S21 year: 2019 ident: 51024_CR44 publication-title: J. Infect. Dis. doi: 10.1093/infdis/jiz010 contributor: fullname: JE Crowe Jr – volume: 6 start-page: 46 year: 2018 ident: 51024_CR11 publication-title: Vaccines doi: 10.3390/vaccines6030046 contributor: fullname: RD De Vries – volume: 219 start-page: S75 year: 2019 ident: 51024_CR52 publication-title: J. Infect. Dis. doi: 10.1093/infdis/jiz017 contributor: fullname: MC Eichelberger – volume: 33 start-page: 50 year: 2004 ident: 51024_CR78 publication-title: Lab Anim. doi: 10.1038/laban1004-50 contributor: fullname: JA Maher – volume: 9 start-page: 793 year: 2021 ident: 51024_CR15 publication-title: Vaccines doi: 10.3390/vaccines9070793 contributor: fullname: Y Huang – volume: 95 start-page: e01526 year: 2020 ident: 51024_CR17 publication-title: J. Virol. doi: 10.1128/JVI.01526-20 contributor: fullname: ZB Reneer – ident: 51024_CR34 doi: 10.1016/j.xinn.2022.100306 – volume: 219 start-page: S38 year: 2019 ident: 51024_CR43 publication-title: J. Infect. Dis. doi: 10.1093/infdis/jiy696 contributor: fullname: SJ Zost – volume-title: Design and Characterization of Computationally Optimized Broadly Reactive Antigen (Cobra) Vaccines Against Human Seasonal Influenza A (H3N2) Viruses year: 2021 ident: 51024_CR18 contributor: fullname: JD Allen – volume: 10 start-page: a038778 year: 2020 ident: 51024_CR29 publication-title: Cold Spring Harbor Perspect. Med. doi: 10.1101/cshperspect.a038778 contributor: fullname: NC Wu – volume: 19 start-page: 383 year: 2019 ident: 51024_CR4 publication-title: Nat. Rev. Immunol. doi: 10.1038/s41577-019-0143-6 contributor: fullname: F Krammer – volume-title: Broadly Reactive Influenza Neuraminidase-Specific Antibody Mediated Protection in the Mouse and Ferret Animal Models year: 2022 ident: 51024_CR35 contributor: fullname: A Skarlupka – volume: 93 start-page: 10 year: 2019 ident: 51024_CR85 publication-title: J. Virol. doi: 10.1128/JVI.00946-18 contributor: fullname: JD Allen – ident: 51024_CR84 – volume: 71 start-page: 913 year: 2022 ident: 51024_CR8 publication-title: Morb. Mortal. Wkly. Rep. doi: 10.15585/mmwr.mm7129a1 contributor: fullname: A Merced-Morales – volume: 14 start-page: 8 year: 2020 ident: 51024_CR57 publication-title: Front. Med. doi: 10.1007/s11684-020-0739-z contributor: fullname: X Wu – volume: 6 start-page: 2465 year: 2014 ident: 51024_CR48 publication-title: Viruses doi: 10.3390/v6062465 contributor: fullname: TJ Wohlbold – ident: 51024_CR28 doi: 10.1007/82_2014_393 – volume: 26 start-page: 809 year: 2018 ident: 51024_CR2 publication-title: Trends Microbiol. doi: 10.1016/j.tim.2018.05.013 contributor: fullname: EC Hutchinson |
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