Vascular parameters and endothelin-1 measurements in glaucoma patients with low- and high-tension optic disc hemorrhages

• Published in: Scientific reports Vol. 13; no. 1; p. 5023
• Main Authors: Almeida, Izabela N. F., Taniguchi, Elise, Tito, Cecília Victoria Agapito, Dias, Diego Torres, Ushida, Michele, Dorairaj, Syril, Ritch, Robert, Teixeira, Sérgio H., Paranhos, Augusto, Gracitelli, Carolina P. B., Kayser, Cristiane, Prata, Tiago Santos
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 28-03-2023; Nature Publishing Group; Nature Portfolio
• Subjects: 692/699/3161; 692/699/3161/3172; Aged; Blood flow; Blood levels; Doppler effect; Endothelin 1; Glaucoma; Glaucoma, Open-Angle; Humanities and Social Sciences; Humans; Intraocular Pressure; Low Tension Glaucoma; Middle Aged; multidisciplinary; Optic Disk; Optic Nerve Diseases; Prospective Studies; Retinal Hemorrhage - diagnosis; Science; Science (multidisciplinary); Statistical analysis; Visual Fields
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-023-31682-w

This prospective study aimed to compare vascular parameters (endothelin-1 [ET-1] blood levels, laser Doppler imaging [LDI] of distal phalanxes, and nailfold capillaroscopy) between open-angle glaucoma patients with low- and high-tension optic disc hemorrhages (LTDH and HTDH, respectively). The 33 enrolled patients (mean age, 62.3 ± 13 years) were classified as LTDH or HTDH if they presented at the time of DH detection an intraocular pressure (IOP) < 16 mmHg or ≥ 16 mmHg, respectively. Demographic and ophthalmological data, ET-1 concentrations, LDI (before and 1, 10, and 20 min after cold stimulation), and nailfold capillaroscopy findings were evaluated. The ET-1 blood level was 65% higher in the LTDH (2.27 ± 1.46 pg/ml) than in the HTDH (1.37 ± 0.57 pg/ml; p = 0.03) group. Moreover, there was a statistically significant negative correlation between ET-1 blood concentration and IOP at the time of DH detection (r = −0.45, p = 0.02). Blood flow measurements 10 and 20 min after cold stimulation were lower in the LTDH group than in the HTDH group (p < 0.01). Patients developing DH with lower IOPs have higher ET-1 blood levels and more peripheral vascular dysfunction as estimated by LDI than those with higher IOPs. These findings suggest that distinct underlying mechanisms may be involved in patients developing DH within different IOP ranges.