A multi-center, prospective cohort study of whole blood gene expression in the tuberculosis-diabetes interaction

Diabetes mellitus (DM) increases tuberculosis (TB) severity. We compared blood gene expression in adults with pulmonary TB, with or without diabetes mellitus (DM) from sites in Brazil and India. RNA sequencing (RNAseq) performed at baseline and during TB treatment. Publicly available baseline RNAseq...

Full description

Saved in:

Bibliographic Details
Published in:	Scientific reports Vol. 13; no. 1; p. 7769
Main Authors:	Queiroz, Artur T. L., Vinhaes, Caian L., Fukutani, Eduardo R., Gupte, Akshay N., Kumar, Nathella Pavan, Fukutani, Kiyoshi F., Arriaga, María B., Sterling, Timothy R., Babu, Subash, Gaikwad, Sanjay, Karyakarte, Rajesh, Mave, Vidya, Paradhkar, Mandar, Viswanathan, Vijay, Gupta, Amita, Andrade, Bruno B., Kornfeld, Hardy
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 12-05-2023 Nature Publishing Group Nature Portfolio
Subjects:	631/250/254 631/250/255 631/250/256 692/308 692/4017 692/53 Adult Blood Cohort analysis Diabetes Diabetes mellitus Diabetes Mellitus - genetics Diabetes Mellitus - metabolism Gene Expression Genomic instability Humanities and Social Sciences Humans Immune response Insulin resistance Leukocytes (neutrophilic) Microvasculature multidisciplinary Prospective Studies Science Science (multidisciplinary) Tuberculosis Tuberculosis - complications Tuberculosis - genetics Tuberculosis, Pulmonary - complications Tuberculosis, Pulmonary - genetics
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	Diabetes mellitus (DM) increases tuberculosis (TB) severity. We compared blood gene expression in adults with pulmonary TB, with or without diabetes mellitus (DM) from sites in Brazil and India. RNA sequencing (RNAseq) performed at baseline and during TB treatment. Publicly available baseline RNAseq data from South Africa and Romania reported by the TANDEM Consortium were also analyzed. Across the sites, differentially expressed genes varied for each condition (DM, TB, and TBDM) and no pattern classified any one group across all sites. A concise signature of TB disease was identified but this was expressed equally in TB and TBDM. Pathway enrichment analysis failed to distinguish TB from TBDM, although there was a trend for greater neutrophil and innate immune pathway activation in TBDM participants. Pathways associated with insulin resistance, metabolic dysfunction, diabetic complications, and chromosomal instability were positively correlated with glycohemoglobin. The immune response to pulmonary TB as reflected by whole blood gene expression is substantially similar with or without comorbid DM. Gene expression pathways associated with the microvascular and macrovascular complications of DM are upregulated during TB, supporting a syndemic interaction between these coprevalent diseases.
AbstractList	Diabetes mellitus (DM) increases tuberculosis (TB) severity. We compared blood gene expression in adults with pulmonary TB, with or without diabetes mellitus (DM) from sites in Brazil and India. RNA sequencing (RNAseq) performed at baseline and during TB treatment. Publicly available baseline RNAseq data from South Africa and Romania reported by the TANDEM Consortium were also analyzed. Across the sites, differentially expressed genes varied for each condition (DM, TB, and TBDM) and no pattern classified any one group across all sites. A concise signature of TB disease was identified but this was expressed equally in TB and TBDM. Pathway enrichment analysis failed to distinguish TB from TBDM, although there was a trend for greater neutrophil and innate immune pathway activation in TBDM participants. Pathways associated with insulin resistance, metabolic dysfunction, diabetic complications, and chromosomal instability were positively correlated with glycohemoglobin. The immune response to pulmonary TB as reflected by whole blood gene expression is substantially similar with or without comorbid DM. Gene expression pathways associated with the microvascular and macrovascular complications of DM are upregulated during TB, supporting a syndemic interaction between these coprevalent diseases. Abstract Diabetes mellitus (DM) increases tuberculosis (TB) severity. We compared blood gene expression in adults with pulmonary TB, with or without diabetes mellitus (DM) from sites in Brazil and India. RNA sequencing (RNAseq) performed at baseline and during TB treatment. Publicly available baseline RNAseq data from South Africa and Romania reported by the TANDEM Consortium were also analyzed. Across the sites, differentially expressed genes varied for each condition (DM, TB, and TBDM) and no pattern classified any one group across all sites. A concise signature of TB disease was identified but this was expressed equally in TB and TBDM. Pathway enrichment analysis failed to distinguish TB from TBDM, although there was a trend for greater neutrophil and innate immune pathway activation in TBDM participants. Pathways associated with insulin resistance, metabolic dysfunction, diabetic complications, and chromosomal instability were positively correlated with glycohemoglobin. The immune response to pulmonary TB as reflected by whole blood gene expression is substantially similar with or without comorbid DM. Gene expression pathways associated with the microvascular and macrovascular complications of DM are upregulated during TB, supporting a syndemic interaction between these coprevalent diseases.
ArticleNumber	7769
Author	Fukutani, Kiyoshi F. Viswanathan, Vijay Gupte, Akshay N. Queiroz, Artur T. L. Paradhkar, Mandar Babu, Subash Sterling, Timothy R. Vinhaes, Caian L. Karyakarte, Rajesh Arriaga, María B. Gaikwad, Sanjay Gupta, Amita Andrade, Bruno B. Fukutani, Eduardo R. Mave, Vidya Kornfeld, Hardy Kumar, Nathella Pavan
Author_xml	– sequence: 1 givenname: Artur T. L. surname: Queiroz fullname: Queiroz, Artur T. L. organization: Centro de Integração de Dados e Conhecimentos para Saúde, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Laboratório de Inflamação e Biomarcadores, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative – sequence: 2 givenname: Caian L. surname: Vinhaes fullname: Vinhaes, Caian L. organization: Laboratório de Inflamação e Biomarcadores, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Escola Bahiana de Medicina e Saúde Pública (EBMSP) – sequence: 3 givenname: Eduardo R. surname: Fukutani fullname: Fukutani, Eduardo R. organization: Centro de Integração de Dados e Conhecimentos para Saúde, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz – sequence: 4 givenname: Akshay N. surname: Gupte fullname: Gupte, Akshay N. organization: Johns Hopkins Bloomberg School of Public Health – sequence: 5 givenname: Nathella Pavan surname: Kumar fullname: Kumar, Nathella Pavan organization: National Institutes of Health‐ NIRT ‐ International Center for Excellence in Research – sequence: 6 givenname: Kiyoshi F. surname: Fukutani fullname: Fukutani, Kiyoshi F. organization: Laboratório de Inflamação e Biomarcadores, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz – sequence: 7 givenname: María B. surname: Arriaga fullname: Arriaga, María B. organization: Laboratório de Inflamação e Biomarcadores, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative – sequence: 8 givenname: Timothy R. surname: Sterling fullname: Sterling, Timothy R. organization: Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center – sequence: 9 givenname: Subash surname: Babu fullname: Babu, Subash organization: National Institutes of Health‐ NIRT ‐ International Center for Excellence in Research – sequence: 10 givenname: Sanjay surname: Gaikwad fullname: Gaikwad, Sanjay organization: Department of Pulmonary Medicine, Byramjee-Jeejeebhoy Government Medical College and Sassoon General Hospitals – sequence: 11 givenname: Rajesh surname: Karyakarte fullname: Karyakarte, Rajesh organization: Department of Microbiology, Byramjee-Jeejeebhoy Government Medical College and Sassoon General Hospitals – sequence: 12 givenname: Vidya surname: Mave fullname: Mave, Vidya organization: Byramjee-Jeejeebhoy Government Medical College-Johns Hopkins University Clinical Research Site, Johns Hopkins Center for Infectious Diseases in India – sequence: 13 givenname: Mandar surname: Paradhkar fullname: Paradhkar, Mandar organization: Byramjee-Jeejeebhoy Government Medical College-Johns Hopkins University Clinical Research Site, Johns Hopkins Center for Infectious Diseases in India – sequence: 14 givenname: Vijay surname: Viswanathan fullname: Viswanathan, Vijay organization: Prof. M. Viswanathan Diabetes Research Centre – sequence: 15 givenname: Amita surname: Gupta fullname: Gupta, Amita organization: Johns Hopkins Bloomberg School of Public Health – sequence: 16 givenname: Bruno B. surname: Andrade fullname: Andrade, Bruno B. email: bruno.andrade@fiocruz.br organization: Laboratório de Inflamação e Biomarcadores, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Escola Bahiana de Medicina e Saúde Pública (EBMSP), Faculdade de Tecnologia e Ciências, Instituto de Pesquisa Clínica e Translacional – sequence: 17 givenname: Hardy surname: Kornfeld fullname: Kornfeld, Hardy email: hardy.kornfeld@umassmed.edu organization: Department of Medicine, University of Massachusetts Medical School, UMass Chan Medical School
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/37173394$$D View this record in MEDLINE/PubMed
BookMark	eNp9ks9vFCEUxyemxta1_4AHQ-LFg6P8mBngZJpGa5MmXvRMGHjsspmFEZhq_3vZbltbD3KB8L7v8-C978vmKMQATfOa4A8EM_Exd6SXosWUtawTHW_ls-aE4q5vKaP06NH5uDnNeYvr6qnsiHzRHDNOOGOyO2nmM7RbpuJbA6FAeo_mFPMMpvhrQCZuYiool8XeoOjQr02cAI1TjBatIQCC33OCnH0MyAdUNoDKMkIyyxSzz631eoQCuQYrW1doDK-a505PGU7v9lXz48vn7-df26tvF5fnZ1et6TtS2t5wTKXWVvejIHiwdhgEx11He6pH0xMJvSOdAcxH4hhngyaWGBDSamcHzlbN5YFro96qOfmdTjcqaq9uL2JaK52KNxOogYI0wo3MWNdZ7kYuHJO2d4IOho-usj4dWPMy7sDuW5X09AT6NBL8Rq3jtSKYCDwQUQnv7ggp_lwgF7Xz2cA06QBxyYoKwvoqrFNZNW__kW7jkkLt1V5FJRkIx1VFDypT55UTuIfXEKz2BlEHg6hqEHVrECVr0pvH_3hIubdDFbCDINdQWEP6W_s_2D-69MrD
CitedBy_id	crossref_primary_10_1016_j_isci_2024_109135 crossref_primary_10_1016_j_isci_2023_108662 crossref_primary_10_3389_fimmu_2023_1210372
Cites_doi	10.1002/eji.201344301 10.1093/cid/ciac437 10.1098/rstb.2013.0427 10.4049/jimmunol.1000304 10.1016/j.chest.2016.02.675 10.12688/f1000research.7563.1 10.1093/cid/civ611 10.1093/bioinformatics/btp616 10.1038/s41598-019-44513-8 10.1186/1471-2105-12-35 10.1073/pnas.0506580102 10.1089/omi.2011.0118 10.1038/s41598-017-01767-4 10.1016/j.chest.2017.02.032 10.1093/bioinformatics/btw313 10.1093/bioinformatics/btu393 10.1038/nmeth.4197 10.1183/13993003.00804-2021 10.18637/jss.v028.i05 10.1001/jamanetworkopen.2020.27754 10.1186/s12879-020-4843-0 10.1513/AnnalsATS.201305-112OC 10.1039/C5MB00663E 10.1093/infdis/jiw436 10.7554/eLife.46477 10.1038/s41590-018-0225-9 10.1371/journal.pone.0235821 10.1161/CIRCULATIONAHA.105.594929 10.1016/S2213-8587(14)70011-7 10.1093/cid/ciab964 10.1038/s41598-020-65043-8 10.1093/cid/ciaa751 10.1016/j.chest.2017.04.155 10.1016/S2213-8587(14)70164-0 10.1371/journal.pmed.0050152 10.1371/journal.pone.0184753 10.1038/s41591-022-01689-3 10.1165/rcmb.2006-0478OC 10.1093/cid/cix819 10.1093/bioinformatics/bts034 10.5588/ijtld.18.0045 10.1001/jama.2014.18229 10.1136/bmjopen-2015-010542 10.3389/fimmu.2021.631165 10.1080/01621459.1963.10500845 10.1111/j.2517-6161.1995.tb02031.x
ContentType	Journal Article
Contributor	Kulkami, Vandana Ramos, André de Oliveira, Jamile G Figueiredo, Marina C Gupte, Nikhil Lapa-E-Silva, José R Lourenço, Maria C Rolla, Valeria C Cubillos-Angulo, Juan Manuel Mello, Mayla Nascimento, Vanessa de Loiola, Bruna P Andrade, Alice M S Malta-Santos, Hayna Cordeiro-Santos, Marcelo Gomes-Silva, Adriano Ignácio, Francine P Souza, Alexandra B de Sousa Carvalho, Brenda K Rocha, Michael S Brito, Pedro Schmaltz, Carolina A S Moreira, Adriana S R Benjamin, Aline Durovni, Betina Silva, Elisangela C Santos, Saulo R N Costa, Alysson G Rebouças-Silva, Jéssica Garcia, Leandro Sousa Cavalcante, Solange Kristki, Afrânio L West, Kim
Contributor_xml	– sequence: 1 givenname: Alice M S surname: Andrade fullname: Andrade, Alice M S – sequence: 2 givenname: Marina C surname: Figueiredo fullname: Figueiredo, Marina C – sequence: 3 givenname: Vanessa surname: Nascimento fullname: Nascimento, Vanessa – sequence: 4 givenname: Juan Manuel surname: Cubillos-Angulo fullname: Cubillos-Angulo, Juan Manuel – sequence: 5 givenname: Hayna surname: Malta-Santos fullname: Malta-Santos, Hayna – sequence: 6 givenname: Jéssica surname: Rebouças-Silva fullname: Rebouças-Silva, Jéssica – sequence: 7 givenname: Adriano surname: Gomes-Silva fullname: Gomes-Silva, Adriano – sequence: 8 givenname: Saulo R N surname: Santos fullname: Santos, Saulo R N – sequence: 9 givenname: André surname: Ramos fullname: Ramos, André – sequence: 10 givenname: Pedro surname: Brito fullname: Brito, Pedro – sequence: 11 givenname: Carolina A S surname: Schmaltz fullname: Schmaltz, Carolina A S – sequence: 12 givenname: Alysson G surname: Costa fullname: Costa, Alysson G – sequence: 13 givenname: Leandro Sousa surname: Garcia fullname: Garcia, Leandro Sousa – sequence: 14 givenname: Brenda K surname: de Sousa Carvalho fullname: de Sousa Carvalho, Brenda K – sequence: 15 givenname: Bruna P surname: de Loiola fullname: de Loiola, Bruna P – sequence: 16 givenname: Francine P surname: Ignácio fullname: Ignácio, Francine P – sequence: 17 givenname: Maria C surname: Lourenço fullname: Lourenço, Maria C – sequence: 18 givenname: Elisangela C surname: Silva fullname: Silva, Elisangela C – sequence: 19 givenname: Mayla surname: Mello fullname: Mello, Mayla – sequence: 20 givenname: Alexandra B surname: Souza fullname: Souza, Alexandra B – sequence: 21 givenname: Michael S surname: Rocha fullname: Rocha, Michael S – sequence: 22 givenname: Aline surname: Benjamin fullname: Benjamin, Aline – sequence: 23 givenname: Adriana S R surname: Moreira fullname: Moreira, Adriana S R – sequence: 24 givenname: Jamile G surname: de Oliveira fullname: de Oliveira, Jamile G – sequence: 25 givenname: Solange surname: Cavalcante fullname: Cavalcante, Solange – sequence: 26 givenname: Betina surname: Durovni fullname: Durovni, Betina – sequence: 27 givenname: Marcelo surname: Cordeiro-Santos fullname: Cordeiro-Santos, Marcelo – sequence: 28 givenname: Afrânio L surname: Kristki fullname: Kristki, Afrânio L – sequence: 29 givenname: Valeria C surname: Rolla fullname: Rolla, Valeria C – sequence: 30 givenname: José R surname: Lapa-E-Silva fullname: Lapa-E-Silva, José R – sequence: 31 givenname: Kim surname: West fullname: West, Kim – sequence: 32 givenname: Vandana surname: Kulkami fullname: Kulkami, Vandana – sequence: 33 givenname: Nikhil surname: Gupte fullname: Gupte, Nikhil
Copyright	The Author(s) 2023 2023. The Author(s). The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml	– notice: The Author(s) 2023 – notice: 2023. The Author(s). – notice: The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
CorporateAuthor	RePORT Brazil RePORT India Consortia the RePORT Brazil
CorporateAuthor_xml	– name: RePORT Brazil – name: RePORT India Consortia – name: the RePORT Brazil
DBID	C6C CGR CUY CVF ECM EIF NPM AAYXX CITATION 3V. 7X7 7XB 88A 88E 88I 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. LK8 M0S M1P M2P M7P PIMPY PQEST PQQKQ PQUKI Q9U 7X8 5PM DOA
DOI	10.1038/s41598-023-34847-9
DatabaseName	SpringerOpen Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef ProQuest Central (Corporate) ProQuest Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) Science Database (Alumni Edition) ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection AUTh Library subscriptions: ProQuest Central ProQuest Natural Science Collection ProQuest One Community College ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) Science Database Biological Science Database Publicly Available Content Database ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central Basic MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals
DatabaseTitle	MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Publicly Available Content Database ProQuest Central Student ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest Natural Science Collection ProQuest Biology Journals (Alumni Edition) ProQuest Central Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Biological Science Collection ProQuest Medical Library (Alumni) ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest Central Basic ProQuest Science Journals ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	Publicly Available Content Database MEDLINE MEDLINE - Academic CrossRef
Database_xml	– sequence: 1 dbid: DOA name: Directory of Open Access Journals url: http://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: ECM name: MEDLINE url: https://search.ebscohost.com/login.aspx?direct=true&db=cmedm&site=ehost-live sourceTypes: Index Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Biology
EISSN	2045-2322
EndPage	7769
ExternalDocumentID	oai_doaj_org_article_62e9c8fb3cdf4d7fb78f39d5f826c7bf 10_1038_s41598_023_34847_9 37173394
Genre	Multicenter Study Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural
GrantInformation_xml	– fundername: CRDF Global grantid: USB1-31149-XX-13 funderid: http://dx.doi.org/10.13039/100004419 – fundername: National Institute of Allergy and Infectious Diseases grantid: U01AI069923; OISE-17-63459-1 funderid: http://dx.doi.org/10.13039/100000060 – fundername: Division of Intramural Research, National Institute of Allergy and Infectious Diseases grantid: DAA3-18-64718-1 funderid: http://dx.doi.org/10.13039/100006492 – fundername: NIAID NIH HHS grantid: U01 AI069923 – fundername: NIAID NIH HHS grantid: R01 AI120790 – fundername: ; grantid: DAA3-18-64718-1 – fundername: ; grantid: U01AI069923; OISE-17-63459-1 – fundername: ; grantid: USB1-31149-XX-13
GroupedDBID	0R~ 3V. 4.4 53G 5VS 7X7 88A 88E 88I 8FE 8FH 8FI 8FJ AAFWJ AAJSJ AAKDD ABDBF ABUWG ACGFS ACSMW ADBBV ADRAZ AENEX AFKRA AJTQC ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS AZQEC BAWUL BBNVY BCNDV BENPR BHPHI BPHCQ BVXVI C6C CCPQU DIK DWQXO EBD EBLON EBS ESX FYUFA GNUQQ GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE KQ8 LK8 M0L M1P M2P M48 M7P M~E NAO OK1 PIMPY PQQKQ PROAC PSQYO RIG RNT RNTTT RPM SNYQT UKHRP CGR CUY CVF ECM EIF NPM AAYXX CITATION 7XB 8FK K9. PQEST PQUKI Q9U 7X8 5PM AFPKN
ID	FETCH-LOGICAL-c541t-5c7029aada5b8106dd6687044252abc519e5f14ce07b1f3736a1d1ce89dafd673
IEDL.DBID	RPM
ISSN	2045-2322
IngestDate	Tue Oct 22 15:11:56 EDT 2024 Tue Sep 17 21:32:08 EDT 2024 Thu Oct 24 23:09:03 EDT 2024 Sat Nov 09 14:38:09 EST 2024 Fri Nov 22 02:04:25 EST 2024 Wed Oct 16 00:39:34 EDT 2024 Fri Oct 11 20:45:59 EDT 2024
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	1
Language	English
License	2023. The Author(s). Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c541t-5c7029aada5b8106dd6687044252abc519e5f14ce07b1f3736a1d1ce89dafd673
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
OpenAccessLink	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180618/
PMID	37173394
PQID	2812916170
PQPubID	2041939
PageCount	1
ParticipantIDs	doaj_primary_oai_doaj_org_article_62e9c8fb3cdf4d7fb78f39d5f826c7bf pubmedcentral_primary_oai_pubmedcentral_nih_gov_10180618 proquest_miscellaneous_2813561873 proquest_journals_2812916170 crossref_primary_10_1038_s41598_023_34847_9 pubmed_primary_37173394 springer_journals_10_1038_s41598_023_34847_9
PublicationCentury	2000
PublicationDate	2023-05-12
PublicationDateYYYYMMDD	2023-05-12
PublicationDate_xml	– month: 05 year: 2023 text: 2023-05-12 day: 12
PublicationDecade	2020
PublicationPlace	London
PublicationPlace_xml	– name: London – name: England
PublicationTitle	Scientific reports
PublicationTitleAbbrev	Sci Rep
PublicationTitleAlternate	Sci Rep
PublicationYear	2023
Publisher	Nature Publishing Group UK Nature Publishing Group Nature Portfolio
Publisher_xml	– name: Nature Publishing Group UK – name: Nature Publishing Group – name: Nature Portfolio
References	Eckold (CR20) 2020; 72 Corrales-Medina (CR22) 2015; 313 Magee (CR9) 2018; 22 Breiman (CR44) 2001; 45 Guangchuang, Wang, Han, He (CR38) 2012; 16 van Crevel, Dockrell (CR32) 2014; 2 Kulkarni (CR46) 2021; 12 Patro, Duggal, Love, Irizarry, Kingsford (CR33) 2017; 14 Oliveira-de-Souza (CR10) 2019; 9 Gu, Eils, Schlesner (CR42) 2016; 32 Critchley (CR1) 2017; 152 Kumar (CR21) 2013; 10 Vallerskog, Martens, Kornfeld (CR16) 2010; 184 Martinez, Ketheesan, West, Vallerskog, Kornfeld (CR17) 2016; 214 Martinez, Kornfeld (CR5) 2014; 44 Penn-Nicholson (CR25) 2020; 10 Kuhn (CR43) 2008; 28 Eckold (CR8) 2021; 72 Gupte (CR30) 2016; 6 Hamilton (CR28) 2015; 61 Degner, Wang, Golub, Karakousis (CR26) 2018; 66 Xie, Xu, Bowe, Al-Aly (CR23) 2022; 28 Martens (CR15) 2007; 37 Mathad (CR47) 2022; 75 Linh (CR31) 2021; 58 Soneson, Love, Robinson (CR34) 2015; 4 Jeon, Murray (CR3) 2008; 5 Gu, Gu, Eils, Schlesner, Brors (CR49) 2014; 30 Kumar (CR13) 2017; 12 Yu, He (CR39) 2016; 12 Chen, Boutros (CR37) 2011; 12 Martinez, Kornfeld (CR18) 2014; 44 Kornfeld (CR29) 2016; 149 Blankley (CR6) 2014; 369 Singhania, Wilkinson, Rodrigue, Haldar, O'Garra (CR12) 2018; 19 Kumar (CR11) 2019 Subramanian (CR48) 2005; 102 Csardi, Nepusz (CR50) 2006; 1695 Prada-Medina (CR7) 2017; 7 Barreda (CR19) 2020; 20 Padmapriydarsini (CR27) 2021 Robinson, McCarthy, Smyth (CR35) 2010; 26 Kumar (CR14) 2020; 3 Ronacher (CR2) 2017; 152 Odone, Houben, White, Lonnroth (CR4) 2014; 2 Zou, O'Malley, Mauri (CR45) 2007; 115 Ward (CR41) 1963; 58 Leek, Johnson, Parker, Jaffe, Storey (CR40) 2012; 28 Benjamini, Hochberg (CR36) 1995; 57 Basham, Smith, Romanowski, Johnston (CR24) 2020; 15 A Odone (34847_CR4) 2014; 2 MJ Magee (34847_CR9) 2018; 22 G Csardi (34847_CR50) 2006; 1695 CA Prada-Medina (34847_CR7) 2017; 7 KH Zou (34847_CR45) 2007; 115 H Chen (34847_CR37) 2011; 12 C Padmapriydarsini (34847_CR27) 2021 D Oliveira-de-Souza (34847_CR10) 2019; 9 Z Gu (34847_CR49) 2014; 30 CY Jeon (34847_CR3) 2008; 5 VF Corrales-Medina (34847_CR22) 2015; 313 Z Gu (34847_CR42) 2016; 32 Y Benjamini (34847_CR36) 1995; 57 N Martinez (34847_CR5) 2014; 44 A Subramanian (34847_CR48) 2005; 102 CA Basham (34847_CR24) 2020; 15 H Kornfeld (34847_CR29) 2016; 149 N Martinez (34847_CR18) 2014; 44 CD Hamilton (34847_CR28) 2015; 61 R Patro (34847_CR33) 2017; 14 C Eckold (34847_CR8) 2021; 72 J Ward (34847_CR41) 1963; 58 NN Barreda (34847_CR19) 2020; 20 A Penn-Nicholson (34847_CR25) 2020; 10 G Yu (34847_CR39) 2016; 12 JA Critchley (34847_CR1) 2017; 152 JS Mathad (34847_CR47) 2022; 75 V Kulkarni (34847_CR46) 2021; 12 S Blankley (34847_CR6) 2014; 369 NP Kumar (34847_CR14) 2020; 3 L Breiman (34847_CR44) 2001; 45 K Ronacher (34847_CR2) 2017; 152 R van Crevel (34847_CR32) 2014; 2 T Vallerskog (34847_CR16) 2010; 184 NP Kumar (34847_CR11) 2019 NP Kumar (34847_CR21) 2013; 10 M Kuhn (34847_CR43) 2008; 28 NR Degner (34847_CR26) 2018; 66 Y Xie (34847_CR23) 2022; 28 N Martinez (34847_CR17) 2016; 214 NN Linh (34847_CR31) 2021; 58 C Eckold (34847_CR20) 2020; 72 Y Guangchuang (34847_CR38) 2012; 16 NP Kumar (34847_CR13) 2017; 12 JT Leek (34847_CR40) 2012; 28 C Soneson (34847_CR34) 2015; 4 GW Martens (34847_CR15) 2007; 37 A Gupte (34847_CR30) 2016; 6 MD Robinson (34847_CR35) 2010; 26 A Singhania (34847_CR12) 2018; 19
References_xml	– volume: 44 start-page: 617 year: 2014 end-page: 626 ident: CR5 article-title: Diabetes and immunity to tuberculosis publication-title: Eur. J. Immunol. doi: 10.1002/eji.201344301 contributor: fullname: Kornfeld – volume: 75 start-page: 2239 year: 2022 end-page: 2242 ident: CR47 article-title: Transcriptional analysis for tuberculosis in pregnant women from the PRACHITi study publication-title: Clin. Infect. Dis. doi: 10.1093/cid/ciac437 contributor: fullname: Mathad – volume: 369 start-page: 20130427 year: 2014 ident: CR6 article-title: The application of transcriptional blood signatures to enhance our understanding of the host response to infection: the example of tuberculosis publication-title: Philos. Trans. R. Soc. Lond. B Biol. Sci. doi: 10.1098/rstb.2013.0427 contributor: fullname: Blankley – volume: 184 start-page: 6275 year: 2010 end-page: 6282 ident: CR16 article-title: Diabetic mice display a delayed adaptive immune response to publication-title: J. Immunol. doi: 10.4049/jimmunol.1000304 contributor: fullname: Kornfeld – volume: 149 start-page: 1501 year: 2016 end-page: 1508 ident: CR29 article-title: High prevalence and heterogeneity of diabetes in patients with TB in South India: A report from the Effects of Diabetes on Tuberculosis Severity (EDOTS) study publication-title: Chest doi: 10.1016/j.chest.2016.02.675 contributor: fullname: Kornfeld – volume: 57 start-page: 289 year: 1995 end-page: 300 ident: CR36 article-title: Controlling the false discovery rate: A practical and powerful approach to multiple testing publication-title: J. R. Stat. Soc. contributor: fullname: Hochberg – volume: 4 start-page: 1521 year: 2015 ident: CR34 article-title: Differential analyses for RNA-seq: Transcript-level estimates improve gene-level inferences publication-title: F1000Research doi: 10.12688/f1000research.7563.1 contributor: fullname: Robinson – volume: 61 start-page: S155 issue: Suppl 3 year: 2015 end-page: 159 ident: CR28 article-title: RePORT international: Advancing tuberculosis biomarker research through global collaboration publication-title: Clin. Infect. Dis. doi: 10.1093/cid/civ611 contributor: fullname: Hamilton – volume: 26 start-page: 139 year: 2010 end-page: 140 ident: CR35 article-title: edgeR: A bioconductor package for differential expression analysis of digital gene expression data publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp616 contributor: fullname: Smyth – volume: 9 start-page: 8002 year: 2019 ident: CR10 article-title: Molecular degree of perturbation of plasma inflammatory markers associated with tuberculosis reveals distinct disease profiles between Indian and Chinese populations publication-title: Sci. Rep. doi: 10.1038/s41598-019-44513-8 contributor: fullname: Oliveira-de-Souza – volume: 12 start-page: 35 year: 2011 ident: CR37 article-title: VennDiagram: A package for the generation of highly-customizable Venn and Euler diagrams in R publication-title: BMC Bioinform. doi: 10.1186/1471-2105-12-35 contributor: fullname: Boutros – volume: 102 start-page: 15545 year: 2005 end-page: 15550 ident: CR48 article-title: Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.0506580102 contributor: fullname: Subramanian – volume: 16 start-page: 284 year: 2012 end-page: 287 ident: CR38 article-title: clusterProfiler: An R package for comparing biological themes among gene clusters publication-title: OMICS doi: 10.1089/omi.2011.0118 contributor: fullname: He – volume: 7 start-page: 1999 year: 2017 ident: CR7 article-title: Systems immunology of diabetes-tuberculosis comorbidity reveals signatures of disease complications publication-title: Sci. Rep. doi: 10.1038/s41598-017-01767-4 contributor: fullname: Prada-Medina – volume: 152 start-page: 174 year: 2017 end-page: 180 ident: CR2 article-title: Defining a research agenda to address the converging epidemics of tuberculosis and diabetes: Part 2: Underlying biologic mechanisms publication-title: Chest doi: 10.1016/j.chest.2017.02.032 contributor: fullname: Ronacher – volume: 32 start-page: 2847 year: 2016 end-page: 2849 ident: CR42 article-title: Complex heatmaps reveal patterns and correlations in multidimensional genomic data publication-title: Bioinformatics doi: 10.1093/bioinformatics/btw313 contributor: fullname: Schlesner – volume: 30 start-page: 2811 year: 2014 end-page: 2812 ident: CR49 article-title: Circlize implements and enhances circular visualization in R publication-title: Bioinformatics doi: 10.1093/bioinformatics/btu393 contributor: fullname: Brors – volume: 14 start-page: 417 year: 2017 end-page: 419 ident: CR33 article-title: Salmon provides fast and bias-aware quantification of transcript expression publication-title: Nat. Methods doi: 10.1038/nmeth.4197 contributor: fullname: Kingsford – volume: 58 start-page: 2100804 year: 2021 ident: CR31 article-title: World health organization treatment outcome definitions for tuberculosis: 2021 update publication-title: Eur. Respir. J. doi: 10.1183/13993003.00804-2021 contributor: fullname: Linh – volume: 28 start-page: 1 year: 2008 end-page: 26 ident: CR43 article-title: Building predictive models in R using the caret package publication-title: J. Stat. Softw. doi: 10.18637/jss.v028.i05 contributor: fullname: Kuhn – volume: 3 start-page: e2027754 year: 2020 ident: CR14 article-title: Association of plasma matrix metalloproteinase and tissue inhibitors of matrix metalloproteinase levels with adverse treatment outcomes among patients with pulmonary tuberculosis publication-title: JAMA Netw. Open doi: 10.1001/jamanetworkopen.2020.27754 contributor: fullname: Kumar – volume: 20 start-page: 139 year: 2020 ident: CR19 article-title: Severe pulmonary radiological manifestations are associated with a distinct biochemical profile in blood of tuberculosis patients with dysglycemia publication-title: BMC Infect. Dis. doi: 10.1186/s12879-020-4843-0 contributor: fullname: Barreda – volume: 10 start-page: 441 year: 2013 end-page: 449 ident: CR21 article-title: Type 2 diabetes mellitus coincident with pulmonary tuberculosis is associated with heightened systemic type 1, type 17 and other pro-inflammatory cytokines publication-title: Ann. Am. Thorac. Soc. doi: 10.1513/AnnalsATS.201305-112OC contributor: fullname: Kumar – volume: 12 start-page: 477 year: 2016 end-page: 479 ident: CR39 article-title: ReactomePA: An R/Bioconductor package for reactome pathway analysis and visualization publication-title: Mol. BioSyst. doi: 10.1039/C5MB00663E contributor: fullname: He – volume: 214 start-page: 1629 year: 2016 end-page: 1637 ident: CR17 article-title: Impaired recognition of by alveolar macrophages from diabetic mice publication-title: J. Infect. Dis. doi: 10.1093/infdis/jiw436 contributor: fullname: Kornfeld – year: 2019 ident: CR11 article-title: Persistent inflammation during anti-tuberculosis treatment with diabetes comorbidity publication-title: eLife doi: 10.7554/eLife.46477 contributor: fullname: Kumar – volume: 19 start-page: 1159 year: 2018 end-page: 1168 ident: CR12 article-title: The value of transcriptomics in advancing knowledge of the immune response and diagnosis in tuberculosis publication-title: Nat. Immunol. doi: 10.1038/s41590-018-0225-9 contributor: fullname: O'Garra – volume: 15 start-page: e0235821 year: 2020 ident: CR24 article-title: Cardiovascular morbidity and mortality among persons diagnosed with tuberculosis: A systematic review and meta-analysis publication-title: PLoS One doi: 10.1371/journal.pone.0235821 contributor: fullname: Johnston – volume: 115 start-page: 654 year: 2007 end-page: 657 ident: CR45 article-title: Receiver-operating characteristic analysis for evaluating diagnostic tests and predictive models publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.105.594929 contributor: fullname: Mauri – volume: 2 start-page: 270 year: 2014 end-page: 272 ident: CR32 article-title: TANDEM: Understanding diabetes and tuberculosis publication-title: Lancet Diab. Endocrinol. doi: 10.1016/S2213-8587(14)70011-7 contributor: fullname: Dockrell – year: 2021 ident: CR27 article-title: Randomized trial of metformin with anti-tuberculosis drugs for early sputum conversion in adults with pulmonary tuberculosis publication-title: Clin. Infect. Dis. doi: 10.1093/cid/ciab964 contributor: fullname: Padmapriydarsini – volume: 10 start-page: 8629 year: 2020 ident: CR25 article-title: RISK6, a 6-gene transcriptomic signature of TB disease risk, diagnosis and treatment response publication-title: Sci. Rep. doi: 10.1038/s41598-020-65043-8 contributor: fullname: Penn-Nicholson – volume: 72 start-page: 69 year: 2020 end-page: 78 ident: CR20 article-title: Impact of intermediate hyperglycaemia as well as diabetes on immune dysfunction in tuberculosis publication-title: Clin. Infect. Dis. doi: 10.1093/cid/ciaa751 contributor: fullname: Eckold – volume: 152 start-page: 165 year: 2017 end-page: 173 ident: CR1 article-title: Defining a research agenda to address the converging epidemics of tuberculosis and diabetes: Part 1: Epidemiology and clinical management publication-title: Chest doi: 10.1016/j.chest.2017.04.155 contributor: fullname: Critchley – volume: 2 start-page: 754 year: 2014 end-page: 764 ident: CR4 article-title: The effect of diabetes and undernutrition trends on reaching 2035 global tuberculosis targets publication-title: Lancet Diab. Endocrinol. doi: 10.1016/S2213-8587(14)70164-0 contributor: fullname: Lonnroth – volume: 5 start-page: e152 year: 2008 ident: CR3 article-title: Diabetes mellitus increases the risk of active tuberculosis: A systematic review of 13 observational studies publication-title: PLoS Med. doi: 10.1371/journal.pmed.0050152 contributor: fullname: Murray – volume: 12 start-page: e0184753 year: 2017 ident: CR13 article-title: Heightened circulating levels of antimicrobial peptides in tuberculosis-diabetes co-morbidity and reversal upon treatment publication-title: PLoS One doi: 10.1371/journal.pone.0184753 contributor: fullname: Kumar – volume: 28 start-page: 583 year: 2022 end-page: 590 ident: CR23 article-title: Long-term cardiovascular outcomes of COVID-19 publication-title: Nat. Med. doi: 10.1038/s41591-022-01689-3 contributor: fullname: Al-Aly – volume: 72 start-page: 69 year: 2021 end-page: 78 ident: CR8 article-title: Impact of intermediate hyperglycemia and diabetes on immune dysfunction in tuberculosis publication-title: Clin. Infect. Dis. doi: 10.1093/cid/ciaa751 contributor: fullname: Eckold – volume: 37 start-page: 518 year: 2007 end-page: 524 ident: CR15 article-title: Tuberculosis susceptibility of diabetic mice publication-title: Am. J. Respir. Cell Mol. Biol. doi: 10.1165/rcmb.2006-0478OC contributor: fullname: Martens – volume: 66 start-page: 198 year: 2018 end-page: 205 ident: CR26 article-title: Metformin use reverses the increased mortality associated with diabetes mellitus during tuberculosis treatment publication-title: Clin. Infect. Dis. doi: 10.1093/cid/cix819 contributor: fullname: Karakousis – volume: 28 start-page: 882 year: 2012 end-page: 883 ident: CR40 article-title: The sva package for removing batch effects and other unwanted variation in high-throughput experiments publication-title: Bioinformatics doi: 10.1093/bioinformatics/bts034 contributor: fullname: Storey – volume: 22 start-page: 1258 year: 2018 end-page: 1268 ident: CR9 article-title: Convergence of non-communicable diseases and tuberculosis: A two-way street? publication-title: Int. J. Tuberc. Lung Dis. doi: 10.5588/ijtld.18.0045 contributor: fullname: Magee – volume: 45 start-page: 2 year: 2001 end-page: 32 ident: CR44 article-title: Random forests publication-title: Mach. Learn. contributor: fullname: Breiman – volume: 313 start-page: 264 year: 2015 end-page: 274 ident: CR22 article-title: Association between hospitalization for pneumonia and subsequent risk of cardiovascular disease publication-title: JAMA doi: 10.1001/jama.2014.18229 contributor: fullname: Corrales-Medina – volume: 6 start-page: e010542 year: 2016 ident: CR30 article-title: Cohort for tuberculosis research by the Indo-US medical partnership (CTRIUMPH): Protocol for a multicentric prospective observational study publication-title: BMJ Open doi: 10.1136/bmjopen-2015-010542 contributor: fullname: Gupte – volume: 12 start-page: 631165 year: 2021 ident: CR46 article-title: A two-gene signature for tuberculosis diagnosis in persons with advanced HIV publication-title: Front. Immunol. doi: 10.3389/fimmu.2021.631165 contributor: fullname: Kulkarni – volume: 44 start-page: 617 year: 2014 end-page: 626 ident: CR18 article-title: Diabetes and immunity to tuberculosis publication-title: Eur. J. Immunol. doi: 10.1002/eji.201344301 contributor: fullname: Kornfeld – volume: 58 start-page: 236 year: 1963 end-page: 244 ident: CR41 article-title: Hierarchical grouping to optimize an objective function publication-title: J. Am. Stat. Assoc. doi: 10.1080/01621459.1963.10500845 contributor: fullname: Ward – volume: 1695 start-page: 1 year: 2006 end-page: 9 ident: CR50 article-title: The Igraph software package for complex network research publication-title: InterJ. Complex Syst. contributor: fullname: Nepusz – volume: 12 start-page: 631165 year: 2021 ident: 34847_CR46 publication-title: Front. Immunol. doi: 10.3389/fimmu.2021.631165 contributor: fullname: V Kulkarni – volume: 12 start-page: e0184753 year: 2017 ident: 34847_CR13 publication-title: PLoS One doi: 10.1371/journal.pone.0184753 contributor: fullname: NP Kumar – volume: 214 start-page: 1629 year: 2016 ident: 34847_CR17 publication-title: J. Infect. Dis. doi: 10.1093/infdis/jiw436 contributor: fullname: N Martinez – volume: 5 start-page: e152 year: 2008 ident: 34847_CR3 publication-title: PLoS Med. doi: 10.1371/journal.pmed.0050152 contributor: fullname: CY Jeon – volume: 22 start-page: 1258 year: 2018 ident: 34847_CR9 publication-title: Int. J. Tuberc. Lung Dis. doi: 10.5588/ijtld.18.0045 contributor: fullname: MJ Magee – volume: 15 start-page: e0235821 year: 2020 ident: 34847_CR24 publication-title: PLoS One doi: 10.1371/journal.pone.0235821 contributor: fullname: CA Basham – volume: 12 start-page: 35 year: 2011 ident: 34847_CR37 publication-title: BMC Bioinform. doi: 10.1186/1471-2105-12-35 contributor: fullname: H Chen – volume: 369 start-page: 20130427 year: 2014 ident: 34847_CR6 publication-title: Philos. Trans. R. Soc. Lond. B Biol. Sci. doi: 10.1098/rstb.2013.0427 contributor: fullname: S Blankley – volume: 44 start-page: 617 year: 2014 ident: 34847_CR5 publication-title: Eur. J. Immunol. doi: 10.1002/eji.201344301 contributor: fullname: N Martinez – volume: 115 start-page: 654 year: 2007 ident: 34847_CR45 publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.105.594929 contributor: fullname: KH Zou – volume: 149 start-page: 1501 year: 2016 ident: 34847_CR29 publication-title: Chest doi: 10.1016/j.chest.2016.02.675 contributor: fullname: H Kornfeld – volume: 58 start-page: 236 year: 1963 ident: 34847_CR41 publication-title: J. Am. Stat. Assoc. doi: 10.1080/01621459.1963.10500845 contributor: fullname: J Ward – volume: 9 start-page: 8002 year: 2019 ident: 34847_CR10 publication-title: Sci. Rep. doi: 10.1038/s41598-019-44513-8 contributor: fullname: D Oliveira-de-Souza – volume: 2 start-page: 754 year: 2014 ident: 34847_CR4 publication-title: Lancet Diab. Endocrinol. doi: 10.1016/S2213-8587(14)70164-0 contributor: fullname: A Odone – volume: 6 start-page: e010542 year: 2016 ident: 34847_CR30 publication-title: BMJ Open doi: 10.1136/bmjopen-2015-010542 contributor: fullname: A Gupte – volume: 28 start-page: 583 year: 2022 ident: 34847_CR23 publication-title: Nat. Med. doi: 10.1038/s41591-022-01689-3 contributor: fullname: Y Xie – volume: 28 start-page: 882 year: 2012 ident: 34847_CR40 publication-title: Bioinformatics doi: 10.1093/bioinformatics/bts034 contributor: fullname: JT Leek – year: 2019 ident: 34847_CR11 publication-title: eLife doi: 10.7554/eLife.46477 contributor: fullname: NP Kumar – volume: 7 start-page: 1999 year: 2017 ident: 34847_CR7 publication-title: Sci. Rep. doi: 10.1038/s41598-017-01767-4 contributor: fullname: CA Prada-Medina – volume: 184 start-page: 6275 year: 2010 ident: 34847_CR16 publication-title: J. Immunol. doi: 10.4049/jimmunol.1000304 contributor: fullname: T Vallerskog – volume: 4 start-page: 1521 year: 2015 ident: 34847_CR34 publication-title: F1000Research doi: 10.12688/f1000research.7563.1 contributor: fullname: C Soneson – volume: 26 start-page: 139 year: 2010 ident: 34847_CR35 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp616 contributor: fullname: MD Robinson – volume: 19 start-page: 1159 year: 2018 ident: 34847_CR12 publication-title: Nat. Immunol. doi: 10.1038/s41590-018-0225-9 contributor: fullname: A Singhania – volume: 72 start-page: 69 year: 2020 ident: 34847_CR20 publication-title: Clin. Infect. Dis. doi: 10.1093/cid/ciaa751 contributor: fullname: C Eckold – volume: 30 start-page: 2811 year: 2014 ident: 34847_CR49 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btu393 contributor: fullname: Z Gu – volume: 3 start-page: e2027754 year: 2020 ident: 34847_CR14 publication-title: JAMA Netw. Open doi: 10.1001/jamanetworkopen.2020.27754 contributor: fullname: NP Kumar – volume: 45 start-page: 2 year: 2001 ident: 34847_CR44 publication-title: Mach. Learn. contributor: fullname: L Breiman – volume: 20 start-page: 139 year: 2020 ident: 34847_CR19 publication-title: BMC Infect. Dis. doi: 10.1186/s12879-020-4843-0 contributor: fullname: NN Barreda – volume: 12 start-page: 477 year: 2016 ident: 34847_CR39 publication-title: Mol. BioSyst. doi: 10.1039/C5MB00663E contributor: fullname: G Yu – volume: 57 start-page: 289 year: 1995 ident: 34847_CR36 publication-title: J. R. Stat. Soc. doi: 10.1111/j.2517-6161.1995.tb02031.x contributor: fullname: Y Benjamini – volume: 61 start-page: S155 issue: Suppl 3 year: 2015 ident: 34847_CR28 publication-title: Clin. Infect. Dis. doi: 10.1093/cid/civ611 contributor: fullname: CD Hamilton – volume: 14 start-page: 417 year: 2017 ident: 34847_CR33 publication-title: Nat. Methods doi: 10.1038/nmeth.4197 contributor: fullname: R Patro – volume: 10 start-page: 441 year: 2013 ident: 34847_CR21 publication-title: Ann. Am. Thorac. Soc. doi: 10.1513/AnnalsATS.201305-112OC contributor: fullname: NP Kumar – volume: 44 start-page: 617 year: 2014 ident: 34847_CR18 publication-title: Eur. J. Immunol. doi: 10.1002/eji.201344301 contributor: fullname: N Martinez – volume: 313 start-page: 264 year: 2015 ident: 34847_CR22 publication-title: JAMA doi: 10.1001/jama.2014.18229 contributor: fullname: VF Corrales-Medina – year: 2021 ident: 34847_CR27 publication-title: Clin. Infect. Dis. doi: 10.1093/cid/ciab964 contributor: fullname: C Padmapriydarsini – volume: 72 start-page: 69 year: 2021 ident: 34847_CR8 publication-title: Clin. Infect. Dis. doi: 10.1093/cid/ciaa751 contributor: fullname: C Eckold – volume: 58 start-page: 2100804 year: 2021 ident: 34847_CR31 publication-title: Eur. Respir. J. doi: 10.1183/13993003.00804-2021 contributor: fullname: NN Linh – volume: 75 start-page: 2239 year: 2022 ident: 34847_CR47 publication-title: Clin. Infect. Dis. doi: 10.1093/cid/ciac437 contributor: fullname: JS Mathad – volume: 152 start-page: 174 year: 2017 ident: 34847_CR2 publication-title: Chest doi: 10.1016/j.chest.2017.02.032 contributor: fullname: K Ronacher – volume: 10 start-page: 8629 year: 2020 ident: 34847_CR25 publication-title: Sci. Rep. doi: 10.1038/s41598-020-65043-8 contributor: fullname: A Penn-Nicholson – volume: 28 start-page: 1 year: 2008 ident: 34847_CR43 publication-title: J. Stat. Softw. doi: 10.18637/jss.v028.i05 contributor: fullname: M Kuhn – volume: 66 start-page: 198 year: 2018 ident: 34847_CR26 publication-title: Clin. Infect. Dis. doi: 10.1093/cid/cix819 contributor: fullname: NR Degner – volume: 32 start-page: 2847 year: 2016 ident: 34847_CR42 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btw313 contributor: fullname: Z Gu – volume: 152 start-page: 165 year: 2017 ident: 34847_CR1 publication-title: Chest doi: 10.1016/j.chest.2017.04.155 contributor: fullname: JA Critchley – volume: 37 start-page: 518 year: 2007 ident: 34847_CR15 publication-title: Am. J. Respir. Cell Mol. Biol. doi: 10.1165/rcmb.2006-0478OC contributor: fullname: GW Martens – volume: 16 start-page: 284 year: 2012 ident: 34847_CR38 publication-title: OMICS doi: 10.1089/omi.2011.0118 contributor: fullname: Y Guangchuang – volume: 1695 start-page: 1 year: 2006 ident: 34847_CR50 publication-title: InterJ. Complex Syst. contributor: fullname: G Csardi – volume: 2 start-page: 270 year: 2014 ident: 34847_CR32 publication-title: Lancet Diab. Endocrinol. doi: 10.1016/S2213-8587(14)70011-7 contributor: fullname: R van Crevel – volume: 102 start-page: 15545 year: 2005 ident: 34847_CR48 publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.0506580102 contributor: fullname: A Subramanian
SSID	ssj0000529419
Score	2.4591656
Snippet	Diabetes mellitus (DM) increases tuberculosis (TB) severity. We compared blood gene expression in adults with pulmonary TB, with or without diabetes mellitus... Abstract Diabetes mellitus (DM) increases tuberculosis (TB) severity. We compared blood gene expression in adults with pulmonary TB, with or without diabetes...
SourceID	doaj pubmedcentral proquest crossref pubmed springer
SourceType	Open Website Open Access Repository Aggregation Database Index Database Publisher
StartPage	7769
SubjectTerms	631/250/254 631/250/255 631/250/256 692/308 692/4017 692/53 Adult Blood Cohort analysis Diabetes Diabetes mellitus Diabetes Mellitus - genetics Diabetes Mellitus - metabolism Gene Expression Genomic instability Humanities and Social Sciences Humans Immune response Insulin resistance Leukocytes (neutrophilic) Microvasculature multidisciplinary Prospective Studies Science Science (multidisciplinary) Tuberculosis Tuberculosis - complications Tuberculosis - genetics Tuberculosis, Pulmonary - complications Tuberculosis, Pulmonary - genetics
SummonAdditionalLinks	– databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3Li9YwEB90QfAivq2uEsGbW7ZN0jyOq-7iyYsK3kKe-IH0W9qvrP73TtL2088HXrw2bRrmkcxkZn4D8IKLGFOiotadQweFc1s7mQOOyfLkQ5Njnfnq4r1890m9Oc8wOftWXzknbIYHngl3KmjUXiXHfEg8yOSkSkyHLqFd7KVLZfdtxE_O1IzqTTVv9VIl0zB1OuJJlavJKKsZxy251gcnUQHs_5OV-Xuy5C8R03IQXdyGW4sFSc7mld-Ba7G_CzfmnpLf7sHlGSlJgnWeKQ4nBP-1llOS3A532JGCKUu2iVzl7rikJK8TlKRI4tclMbYnm56gcUh2k4uDn75sx81Yrze1JKNMDHNNxH34eHH-4fXbemmrUPuOt7u687Kh2tpgO6eQdCEIgVrLUXupdR5NutillvvYSNcmJpmwbWh9VDrYFIRkD-Co3_bxERAXnPShy5XRaBpqq_EDoVuapPAW_dwKXq4kNpczeoYpUW-mzMwQgwwxhSFGV_Aqc2H_Zka-Lg9QHswiD-Zf8lDB8cpDs6jjaCiaMTp7ck0Fz_fDqEg5OmL7uJ3KOwyNSSVZBQ9nlu9XwnKuAtO8AnUgDAdLPRzpN58LWHdBSMNpKzhZ5ebHuv5Oi8f_gxZP4CbNAp_BZukxHO2GKT6F62OYnhV1-Q7vjxvZ priority: 102 providerName: Directory of Open Access Journals
Title	A multi-center, prospective cohort study of whole blood gene expression in the tuberculosis-diabetes interaction
URI	https://link.springer.com/article/10.1038/s41598-023-34847-9 https://www.ncbi.nlm.nih.gov/pubmed/37173394 https://www.proquest.com/docview/2812916170 https://search.proquest.com/docview/2813561873 https://pubmed.ncbi.nlm.nih.gov/PMC10180618 https://doaj.org/article/62e9c8fb3cdf4d7fb78f39d5f826c7bf
Volume	13
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
link	http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELbYSkhcEG9SSmUkbjTdje34cSylFRcQEiBxs_yEldpklWwE_HvGTrKwPC5cYyceeWbiGc_MNwg9ZzyEGAkvVW3BQWHMlFakgGM0LDq_SrHOdHXxXrz9JF9dJJgcPtfC5KR9Z9enzdX1abP-knMrN9duOeeJLd-9Oc-oU7ySywVagHH4i48-InoTxSo1VcisqFz2cEqlSjJCS8rgd1yqvVMog_X_zcL8M1Hyt2hpPoQu76Dbk_WIz0Yq76IbobmHbo79JL_fR5sznBMEy_Sl0J1gWGsupcSpFW63xRlPFrcRf02dcXFOXMcgRQGHb1NSbIPXDQbDEG8HGzo3XLX9ui_nW1qcECa6sR7iAfp4efHh_HU5tVQoXc2qbVk7sSLKGG9qK8Eb9J5z0FgGmkuMdWDOhTpWzIWVsFWkgnJT-coFqbyJngv6EB00bRMeI2y9Fc7XqSoazEJlFLzAVUWi4M6Aj1ugF_MW682InKFzxJtKPTJEA0N0ZohWBXqZuLCbmVCv84O2-6wn3mtOgnIyWup8ZF5EK2SkytcRfCQnbCzQ0cxDPalirwmYMCp5casCPdsNgxKlyIhpQjvkORQMSSlogR6NLN9RQlOeAlWsQHJPGPZI3R8Buc1A3bOcFuhklpufdP17Lw7_f6Un6BZJYp7gZckROth2Q3iKFr0fjvNtw3FWlR_17xoU
link.rule.ids	230,315,729,782,786,866,887,2106,27933,27934,53800,53802
linkProvider	National Library of Medicine
linkToHtml	http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB7RIgQX3oVAASNxo-kmsWPHx1JaFdFWSBSJm-UnrNQmq2Sjln-P7SQLy-PSa5woE89MPOP55jPAG0Ktda6gKS-VT1AIkalioeDoJHHaZKHWGbYuPrPTr9X7g0CTQ6demAja12q-W59f7Nbz7xFbubjQswknNvt0sh9Zp2hezTbgpnfYLPstSx84vQtOcj72yGS4mnV-nQq9ZAVOMfE_5JSvrUORrv9fMebfUMk_6qVxGTq8d90PuA93x8AT7Q3jD-CGrR_CreEoyh-PYLGHIrYwDSLYdgd5IacuTBRO0W2XKFLRosahy3CoLoqYd-QN0CJ7NeJpazSvkY8p0bJXttX9edPNu3Ta4EWBnKIdWikew5fDg7P9o3Q8jSHVJcmXaalZVnApjSxV5RNJYyj1zk680xdSaR8J2tLlRNuMqdxhhqnMTa5txY10hjK8BZt1U9ungJRRTJsyNFT7iJJL7h-gPC8co1r69DiBt5NuxGIg3RCxWI4rMWhSeE2KqEnBE3gX1Le6MxBmxwtN-02Msy5oYbmunMLaOGKYU6xymJvS-fRKM-US2J6UL0Yv7kThox8eEsAsgderYe9_oagia9v08R7sY9CK4QSeDLaykgQHiAPmJIFqzYrWRF0f8RYTOb4nC0lgZzK4X3L9fy6eXf9Nr-D20dnJsTj-cPrxOdwpgq8EltpiGzaXbW9fwEZn-pfR034COJYu0Q
linkToPdf	http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB7RIlAvvKGBAkbiRtMkthPH3ErbFQioKgESN8tPWKlNVtmNgH-P7SQLy-MC18RRJp6ZeMbzzWeAp7Sy1jlcpbxUPkGhVKaKhYKjk9Rpk4daZ9i6eMdOP9bHJ4Em5_nUCxNB-1rND5rzi4Nm_jliKxcXOptwYtnZ26PIOlUVdbYwLtuCy95pc_xTpj7wemNOCz72yeSkzpZ-rQr9ZJikhPqfcso31qJI2f-nOPN3uOQvNdO4FM2u_89H3IBrYwCKDocxN-GSbW7BleFIym-3YXGIIsYwDWLYbh95QaduTBRO0-1WKFLSotahL-FwXRSx78gbokX264irbdC8QT62RKte2U735-1yvkynjV4USCq6oaXiDnyYnbw_epmOpzKkuqTFKi01yzGX0shS1T6hNKaqvNNT7_xYKu0jQlu6gmqbM1U4wkglC1NoW3MjnakYuQvbTdvYXUDKKKZNGRqrfWTJJfcPVLzAjlVa-jQ5gWeTfsRiIN8QsWhOajFoU3htiqhNwRN4EVS4HhmIs-OFtvskxpkXFbZc104RbRw1zClWO8JN6XyapZlyCexNBiBGb14K7KMgHhLBPIEn69veD0NxRTa27eMY4mPRmpEE7g32spaEBKgD4TSBesOSNkTdvOOtJnJ9T1aSwP5kdD_k-vtc3P_3Nz2Gq2fHM_Hm1enrB7CDg7sEslq8B9urrrcPYWtp-kfR2b4DqH4xUQ
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+multi-center%2C+prospective+cohort+study+of+whole+blood+gene+expression+in+the+tuberculosis-diabetes+interaction&rft.jtitle=Scientific+reports&rft.au=Queiroz%2C+Artur+T.+L.&rft.au=Vinhaes%2C+Caian+L.&rft.au=Fukutani%2C+Eduardo+R.&rft.au=Gupte%2C+Akshay+N.&rft.date=2023-05-12&rft.pub=Nature+Publishing+Group+UK&rft.eissn=2045-2322&rft.volume=13&rft.issue=1&rft_id=info:doi/10.1038%2Fs41598-023-34847-9&rft.externalDocID=10_1038_s41598_023_34847_9
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2045-2322&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2045-2322&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2045-2322&client=summon