Forebrain-Specific CRF Overproduction During Development is Sufficient to Induce Enduring Anxiety and Startle Abnormalities in Adult Mice

Corticotropin releasing factor (CRF) regulates physiological and behavioral responses to stress. Trauma in early life or adulthood is associated with increased CRF in the cerebrospinal fluid and heightened anxiety. Genetic variance in CRF receptors is linked to altered risk for stress disorders. Thu...

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Bibliographic Details
Published in:	Neuropsychopharmacology (New York, N.Y.) Vol. 39; no. 6; pp. 1409 - 1419
Main Authors:	TOTH, Mate, GRESACK, Jodi E, BANGASSER, Debra A, PLONA, Zach, VALENTINO, Rita J, FLANDREAU, Elizabeth I, MANSUY, Isabelle M, MERLO-PICH, Emilio, GEYER, Mark A, RISBROUGH, Victoria B
Format:	Journal Article
Language:	English
Published:	Basingstoke Nature Publishing Group 01-05-2014
Subjects:	Animals Anxiety Anxiety - physiopathology Avoidance Learning - physiology Biological and medical sciences Conditioning (Psychology) - physiology Corticotropin-Releasing Hormone - genetics Corticotropin-Releasing Hormone - metabolism Disease Models, Animal Exploratory Behavior - physiology Fear - physiology Female Habituation, Psychophysiologic - physiology Inhibition (Psychology) Male Medical sciences Mice Mice, Inbred C57BL Mice, Transgenic Original Prosencephalon - growth & development Prosencephalon - physiopathology Reflex, Startle - physiology Sensory Gating - physiology Sex Factors Stress, Psychological - physiopathology Rodentia Central nervous system Corticotropin releasing factor Sex Startle reflex Prosencephalon Hypothalamic hormone startle Vertebrata Mammalia Mouse CRF overexpression Adult animal Development Anxiety Hormone releasing factor sex differences
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