DNA methylation age acceleration is associated with ALS age of onset and survival

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Published in:	Acta neuropathologica Vol. 139; no. 5; pp. 943 - 946
Main Authors:	Zhang, Ming, McKeever, Paul M., Xi, Zhengrui, Moreno, Danielle, Sato, Christine, Bergsma, Tessa, McGoldrick, Philip, Keith, Julia, Robertson, Janice, Zinman, Lorne, Rogaeva, Ekaterina
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01-05-2020 Springer Springer Nature B.V
Subjects:	Adolescent Adult Age Factors Age of Onset Aged Aged, 80 and over Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - metabolism Amyotrophic Lateral Sclerosis - mortality Amyotrophic Lateral Sclerosis - pathology Correspondence DNA DNA methylation DNA Methylation - physiology Epigenesis, Genetic - physiology Female Humans Male Medical colleges Medical research Medicine Medicine & Public Health Medicine, Experimental Methylation Middle Aged Nervous system diseases Neurosciences Pathology Young Adult
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Audience	Academic
Author	Zinman, Lorne Bergsma, Tessa Rogaeva, Ekaterina Sato, Christine McGoldrick, Philip McKeever, Paul M. Keith, Julia Xi, Zhengrui Moreno, Danielle Zhang, Ming Robertson, Janice
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Cites_doi	10.1111/acel.13028 10.1016/S1474-4422(14)70324-2 10.1016/B978-0-12-802395-2.00036-5 10.1016/j.molcel.2018.08.008 10.1016/S1474-4422(16)30229-0 10.1038/nrneurol.2014.184 10.1136/jnnp.2010.207464 10.1186/gb-2013-14-10-r115 10.1016/j.ajhg.2013.04.017 10.1007/s00401-017-1713-y
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Copyright	The Author(s) 2020 COPYRIGHT 2020 Springer The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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References	Al-Chalabi, Fang, Hanby, Leigh, Shaw, Ye (CR1) 2010; 81 Swinnen, Robberecht (CR7) 2014; 10 Alafuzoff, Kovacs (CR2) 2017; 145 Field, Robertson, Wang, Havas, Ideker, Adams (CR4) 2018; 71 Rohrer, Nicholas, Cash, van Swieten, Dopper, Jiskoot (CR6) 2015; 14 Xi, Zinman, Moreno, Schymick, Liang, Sato (CR9) 2013; 92 Tang, Ryman, McDade, Jasielec, Buckles, Cairns (CR8) 2016; 15 Horvath (CR5) 2013; 14 Zhang, Tartaglia, Moreno, Sato, McKeever, Weichert (CR10) 2017; 134 Fahy, Brooke, Watson, Good, Vasanawala, Maecker (CR3) 2019; 18 JD Rohrer (2131_CR6) 2015; 14 Z Xi (2131_CR9) 2013; 92 M Zhang (2131_CR10) 2017; 134 A Al-Chalabi (2131_CR1) 2010; 81 AE Field (2131_CR4) 2018; 71 S Horvath (2131_CR5) 2013; 14 M Tang (2131_CR8) 2016; 15 B Swinnen (2131_CR7) 2014; 10 I Alafuzoff (2131_CR2) 2017; 145 GM Fahy (2131_CR3) 2019; 18
References_xml	– volume: 18 start-page: e13028 year: 2019 ident: CR3 article-title: Reversal of epigenetic aging and immunosenescent trends in humans publication-title: Aging Cell doi: 10.1111/acel.13028 contributor: fullname: Maecker – volume: 14 start-page: 253 year: 2015 end-page: 262 ident: CR6 article-title: Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the Genetic Frontotemporal dementia Initiative (GENFI) study: a cross-sectional analysis publication-title: Lancet Neurol doi: 10.1016/S1474-4422(14)70324-2 contributor: fullname: Jiskoot – volume: 145 start-page: 573 year: 2017 end-page: 577 ident: CR2 article-title: Comorbidities publication-title: Handb Clin Neurol doi: 10.1016/B978-0-12-802395-2.00036-5 contributor: fullname: Kovacs – volume: 71 start-page: 882 year: 2018 end-page: 895 ident: CR4 article-title: DNA methylation clocks in aging: categories, causes, and consequences publication-title: Mol Cell doi: 10.1016/j.molcel.2018.08.008 contributor: fullname: Adams – volume: 15 start-page: 1317 year: 2016 end-page: 1325 ident: CR8 article-title: Neurological manifestations of autosomal dominant familial Alzheimer's disease: a comparison of the published literature with the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS) publication-title: Lancet Neurol doi: 10.1016/S1474-4422(16)30229-0 contributor: fullname: Cairns – volume: 10 start-page: 661 year: 2014 end-page: 670 ident: CR7 article-title: The phenotypic variability of amyotrophic lateral sclerosis publication-title: Nat Rev Neurol doi: 10.1038/nrneurol.2014.184 contributor: fullname: Robberecht – volume: 81 start-page: 1324 year: 2010 end-page: 1326 ident: CR1 article-title: An estimate of amyotrophic lateral sclerosis heritability using twin data publication-title: J Neurol Neurosurg Psychiatry doi: 10.1136/jnnp.2010.207464 contributor: fullname: Ye – volume: 14 start-page: R115 year: 2013 ident: CR5 article-title: DNA methylation age of human tissues and cell types publication-title: Genome Biol doi: 10.1186/gb-2013-14-10-r115 contributor: fullname: Horvath – volume: 92 start-page: 981 year: 2013 end-page: 989 ident: CR9 article-title: Hypermethylation of the CpG island near the G4C2 repeat in ALS with a C9orf72 expansion publication-title: Am J Hum Genet doi: 10.1016/j.ajhg.2013.04.017 contributor: fullname: Sato – volume: 134 start-page: 271 year: 2017 end-page: 279 ident: CR10 article-title: DNA methylation age-acceleration is associated with disease duration and age at onset in C9orf72 patients publication-title: Acta Neuropathol doi: 10.1007/s00401-017-1713-y contributor: fullname: Weichert – volume: 71 start-page: 882 year: 2018 ident: 2131_CR4 publication-title: Mol Cell doi: 10.1016/j.molcel.2018.08.008 contributor: fullname: AE Field – volume: 81 start-page: 1324 year: 2010 ident: 2131_CR1 publication-title: J Neurol Neurosurg Psychiatry doi: 10.1136/jnnp.2010.207464 contributor: fullname: A Al-Chalabi – volume: 145 start-page: 573 year: 2017 ident: 2131_CR2 publication-title: Handb Clin Neurol doi: 10.1016/B978-0-12-802395-2.00036-5 contributor: fullname: I Alafuzoff – volume: 18 start-page: e13028 year: 2019 ident: 2131_CR3 publication-title: Aging Cell doi: 10.1111/acel.13028 contributor: fullname: GM Fahy – volume: 134 start-page: 271 year: 2017 ident: 2131_CR10 publication-title: Acta Neuropathol doi: 10.1007/s00401-017-1713-y contributor: fullname: M Zhang – volume: 14 start-page: R115 year: 2013 ident: 2131_CR5 publication-title: Genome Biol doi: 10.1186/gb-2013-14-10-r115 contributor: fullname: S Horvath – volume: 14 start-page: 253 year: 2015 ident: 2131_CR6 publication-title: Lancet Neurol doi: 10.1016/S1474-4422(14)70324-2 contributor: fullname: JD Rohrer – volume: 15 start-page: 1317 year: 2016 ident: 2131_CR8 publication-title: Lancet Neurol doi: 10.1016/S1474-4422(16)30229-0 contributor: fullname: M Tang – volume: 92 start-page: 981 year: 2013 ident: 2131_CR9 publication-title: Am J Hum Genet doi: 10.1016/j.ajhg.2013.04.017 contributor: fullname: Z Xi – volume: 10 start-page: 661 year: 2014 ident: 2131_CR7 publication-title: Nat Rev Neurol doi: 10.1038/nrneurol.2014.184 contributor: fullname: B Swinnen
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SubjectTerms	Adolescent Adult Age Factors Age of Onset Aged Aged, 80 and over Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - metabolism Amyotrophic Lateral Sclerosis - mortality Amyotrophic Lateral Sclerosis - pathology Correspondence DNA DNA methylation DNA Methylation - physiology Epigenesis, Genetic - physiology Female Humans Male Medical colleges Medical research Medicine Medicine & Public Health Medicine, Experimental Methylation Middle Aged Nervous system diseases Neurosciences Pathology Young Adult
Title	DNA methylation age acceleration is associated with ALS age of onset and survival
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