Phylogenetic inference from single-cell RNA-seq data

Tumors are comprised of subpopulations of cancer cells that harbor distinct genetic profiles and phenotypes that evolve over time and during treatment. By reconstructing the course of cancer evolution, we can understand the acquisition of the malignant properties that drive tumor progression. Unfort...

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Bibliographic Details
Published in:	Scientific reports Vol. 13; no. 1; p. 12854
Main Authors:	Liu, Xuan, Griffiths, Jason I., Bishara, Isaac, Liu, Jiayi, Bild, Andrea H., Chang, Jeffrey T.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 08-08-2023 Nature Publishing Group Nature Portfolio
Subjects:	631/114/739 631/67/2329 Algorithms Bayes Theorem Bayesian analysis Breast cancer Cancer Evolution Gene expression Gene Expression Profiling - methods Genetic drift Genotypes Humanities and Social Sciences Humans K-Ras protein Metastases multidisciplinary Neoplasms - genetics Phenotypes Phylogenetics Phylogeny Science Science (multidisciplinary) Sequence Analysis, RNA - methods Single-Cell Analysis - methods Single-Cell Gene Expression Analysis Subpopulations Tumors β-Catenin
Online Access:	Get full text
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