Treatment of Phenytoin Toxicity by the Molecular Adsorbents Recirculating System (MARS)

Purpose: Toxicity is common in patients of epilepsy treated with phenytoin (PHT), requiring careful drug level monitoring and supportive care. Specific treatment options are limited, although charcoal haemofiltration has been used previously. We attempted to demonstrate that severe PHT toxicity can...

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Bibliographic Details
Published in:	Epilepsia (Copenhagen) Vol. 44; no. 2; pp. 265 - 267
Main Authors:	Sen, Sambit, Ratnaraj, Neville, Davies, Nathan A., Mookerjee, Rajeshwar P., Cooper, Christopher E., Patsalos, Philip N., Williams, Roger, Jalan, Rajiv
Format:	Journal Article
Language:	English
Published:	Boston, MA, USA Blackwell Science Inc 01-02-2003 Blackwell
Subjects:	Albumin dialysis Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anticonvulsants - administration & dosage Anticonvulsants - adverse effects Anticonvulsants - pharmacokinetics Biological and medical sciences Drug intoxications. Doping Drug Overdose - blood Drug Overdose - therapy Emergency and intensive care: renal failure. Dialysis management Equipment Design Hemofiltration - instrumentation Humans Intensive care medicine Kidney Failure, Chronic - blood Kidney Failure, Chronic - complications Liver, Artificial Male Medical sciences Middle Aged Oxidative stress Pharmacology. Drug treatments Phenytoin Phenytoin - administration & dosage Phenytoin - adverse effects Phenytoin - pharmacokinetics Protein Binding Renal Dialysis - instrumentation Serum Albumin - metabolism Status Epilepticus - blood Status Epilepticus - drug therapy Treatment Outcome Human Oxidative stress Nervous system diseases Purification Toxicity Epilepsy Drug intoxication Overdosing Albumin dialysis-Phenytoin-Oxidative stress Male Anticonvulsant Blood Cerebral disorder Extrarenal dialysis Chemotherapy Treatment Hemofiltration Central nervous system disease Adult Dialysis Adsorbent Mechanism of action Status epilepticus Phenytoin
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