Analgesic and anti-inflammatory activities of a fraction rich in oncocalyxone A isolated from Auxemma oncocalyx

• Published in: Phytomedicine (Stuttgart) Vol. 11; no. 4; pp. 315 - 322
• Main Authors: Ferreira, M.A.D., Nunes, Osmar D.R.H., Fontenele, Juvenia B., Pessoa, Otília D.L., Lemos, Telma L.G., Viana, Glauce S.B.
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 2004; Urban & Fischer Verlag; Elsevier Science Ltd
• Subjects: Acetic Acid; Analgesic and antiinflammatory activities; Analgesics; Analgesics, Non-Narcotic - administration & dosage; Analgesics, Non-Narcotic - pharmacology; Analgesics, Non-Narcotic - therapeutic use; Animals; Anthraquinones - administration & dosage; Anthraquinones - pharmacology; Anthraquinones - therapeutic use; Anti-Inflammatory Agents - administration & dosage; Anti-Inflammatory Agents - pharmacology; Anti-Inflammatory Agents - therapeutic use; Anti-inflammatory drugs; Auxemma oncocalyx; Boraginaceae; Carrageenan; Dose-Response Relationship, Drug; Edema - chemically induced; Edema - prevention & control; Formaldehyde; Health aspects; Injections, Intraperitoneal; Male; oncocalyxone A; Pain - chemically induced; Pain - prevention & control; Phytotherapy; Plant Extracts - administration & dosage; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Quinone; quinones; Rats; Rats, Wistar; United States; Auxemma oncocalyx; quinones; oncocalyxone A; Analgesic and antiinflammatory activities
• DOI: 10.1078/0944711041495227
• EISSN: 1618-095X
• ISSN: 0944-7113

In the present work we studied the antinociceptive and antiedematogenic effects of a quinone fraction (QF) isolated from the heartwood of
Auxemma oncocalyx Taub. The major constituent of QF, which represented around 80% of this fraction, was a terpenoid quinone named oncocalyxone A (1). Results show that QF (10 and 30 mg/kg body wt., i.p.) significantly inhibited paw edema induced by carrageenan at the second, third, and fourth hours. The effect was dose-dependent and long lasting, and QF was less effective orally. An antiedematogenic effect was also demonstrated in the dextran-induced paw edema. In this model, however, QF was somewhat less potent. QF (1 and 5mg/kg body wt., i.p.) inhibited acetic acid-induced abdominal contractions in mice in a dose-dependent manner. In addition, QF (5 and 10 mg/kg body wt., i.p.) inhibited only the second phase (inflammatory) in the formalin test, and showed no effect in the hot-plate test in mice. The antinociceptive activity of QF was predominantly peripheral and independent of the opioid system. The observed effects of QF are, at least in part, probably due to the presence of oncocalyxone A (1).