Dynamic molecular changes during the first week of human life follow a robust developmental trajectory

Systems biology can unravel complex biology but has not been extensively applied to human newborns, a group highly vulnerable to a wide range of diseases. We optimized methods to extract transcriptomic, proteomic, metabolomic, cytokine/chemokine, and single cell immune phenotyping data from <1 ml...

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Bibliographic Details
Published in:	Nature communications Vol. 10; no. 1; p. 1092
Main Authors:	Lee, Amy H., Shannon, Casey P., Amenyogbe, Nelly, Bennike, Tue B., Diray-Arce, Joann, Idoko, Olubukola T., Gill, Erin E., Ben-Othman, Rym, Pomat, William S., van Haren, Simon D., Cao, Kim-Anh Lê, Cox, Momoudou, Darboe, Alansana, Falsafi, Reza, Ferrari, Davide, Harbeson, Daniel J., He, Daniel, Bing, Cai, Hinshaw, Samuel J., Ndure, Jorjoh, Njie-Jobe, Jainaba, Pettengill, Matthew A., Richmond, Peter C., Ford, Rebecca, Saleu, Gerard, Masiria, Geraldine, Matlam, John Paul, Kirarock, Wendy, Roberts, Elishia, Malek, Mehrnoush, Sanchez-Schmitz, Guzmán, Singh, Amrit, Angelidou, Asimenia, Smolen, Kinga K., Brinkman, Ryan R., Ozonoff, Al, Hancock, Robert E. W., van den Biggelaar, Anita H. J., Steen, Hanno, Tebbutt, Scott J., Kampmann, Beate, Levy, Ofer, Kollmann, Tobias R.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 12-03-2019 Nature Publishing Group Nature Portfolio
Subjects:	38 38/91 49/31 631/136 631/1647/2067 631/1647/320 631/250 631/553/2701 82/58 96/21 Biology Blood Chemokines Chemokines - blood Child Development - physiology Cohort Studies Computer applications Cytokines - blood Data integration Gambia Gene Expression Profiling Humanities and Social Sciences Humans Immunophenotyping Infant, Newborn - blood Infant, Newborn - immunology Interferon Metabolomics multidisciplinary Neonates Ontogeny Papua New Guinea Phenotyping Proteomics Science Science (multidisciplinary) Systems Biology Trajectories Gambia Papua New Guinea
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