Stiffness-Induced Endothelial DLC-1 Expression Forces Leukocyte Spreading through Stabilization of the ICAM-1 Adhesome

Leukocytes follow the well-defined steps of rolling, spreading, and crawling prior to diapedesis through endothelial cells (ECs). We found increased expression of DLC-1 in stiffness-associated diseases like atherosclerosis and pulmonary arterial hypertension. Depletion of DLC-1 in ECs cultured on st...

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Bibliographic Details
Published in:	Cell reports (Cambridge) Vol. 24; no. 12; pp. 3115 - 3124
Main Authors:	Schimmel, Lilian, van der Stoel, Miesje, Rianna, Carmela, van Stalborch, Anne-Marieke, de Ligt, Aafke, Hoogenboezem, Mark, Tol, Simon, van Rijssel, Jos, Szulcek, Robert, Bogaard, Harm Jan, Hofmann, Patrick, Boon, Reinier, Radmacher, Manfred, de Waard, Vivian, Huveneers, Stephan, van Buul, Jaap D.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 18-09-2018 Elsevier
Subjects:	Cells, Cultured diapedesis DLC-1 endothelial GTPase-Activating Proteins - genetics GTPase-Activating Proteins - metabolism Human Umbilical Vein Endothelial Cells - metabolism Human Umbilical Vein Endothelial Cells - physiology Humans ICAM-1 Intercellular Adhesion Molecule-1 - metabolism leukocyte Leukocytes - metabolism Leukocytes - physiology mechanosignaling Microfilament Proteins - metabolism rolling spreading stiffness Transendothelial and Transepithelial Migration transmigration Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Vascular Stiffness rolling transmigration endothelial leukocyte mechanosignaling spreading ICAM-1 diapedesis stiffness DLC-1
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