Prognostic impact of miR-34b/c DNA methylation, gene expression, and promoter polymorphism in HPV-negative oral squamous cell carcinomas

Micro RNAs (miRNAs) have a key role in gene expression regulation in cancer. The aim of the current study is to evaluate the prognostic value of miR-34b/c promoter hypermethylation, gene expression, and polymorphism in HPV-negative oral squamous cell carcinomas (OSCC). MiR-34b/c promoter hypermethyl...

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Bibliographic Details
Published in:	Scientific reports Vol. 12; no. 1; p. 1296
Main Authors:	Supic, Gordana, Stefik, Debora, Ivkovic, Nemanja, Sami, Ahmad, Zeljic, Katarina, Jovic, Sasa, Kozomara, Ruzica, Vojvodic, Danilo, Stosic, Srboljub
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 25-01-2022 Nature Publishing Group Nature Portfolio
Subjects:	631/208 631/337 631/67 692/4028 Adult Aged Aged, 80 and over Alphapapillomavirus - genetics Biomarkers, Tumor - genetics Cancer Case-Control Studies Deoxyribonucleic acid DNA DNA methylation DNA Methylation - genetics Female Follow-Up Studies Gene Expression Gene polymorphism Gene regulation Genotyping Health risks Humanities and Social Sciences Humans Male Medical prognosis Medical screening MicroRNAs - genetics Middle Aged Mouth Neoplasms - genetics Mouth Neoplasms - pathology multidisciplinary Oral cancer Oral carcinoma Oral squamous cell carcinoma Papillomavirus Infections - diagnosis Papillomavirus Infections - virology Patients Polymerase chain reaction Polymorphism Polymorphism, Single Nucleotide Prognosis Promoter Regions, Genetic Risk assessment Science Science (multidisciplinary) Serbia - epidemiology Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck - genetics Squamous Cell Carcinoma of Head and Neck - pathology Survival Therapeutic targets Tumors Serbia
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