Antiviral Activities of Hibiscus sabdariffa L. Tea Extract Against Human Influenza A Virus Rely Largely on Acidic pH but Partially on a Low-pH-Independent Mechanism

Influenza A virus (IAV) infection is perennially one of the leading causes of death worldwide. Effective therapy and vaccination are needed to control viral expansion. However, current anti-IAV drugs risk inducing drug-resistant virus emergence. Although intranasal administration of whole inactivate...

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Bibliographic Details
Published in:	Food and environmental virology Vol. 12; no. 1; pp. 9 - 19
Main Authors:	Takeda, Yohei, Okuyama, Yuko, Nakano, Hiroto, Yaoita, Yasunori, Machida, Koich, Ogawa, Haruko, Imai, Kunitoshi
Format:	Journal Article
Language:	English
Published:	New York Springer US 01-03-2020 Springer Nature B.V
Subjects:	Animals Antigenicity Antiviral activity Antiviral agents Antiviral Agents - administration & dosage Antiviral Agents - chemistry Biomedical and Life Sciences Biomedicine Chemistry/Food Science Drug resistance Female Food Science Hemagglutinins Hibiscus - chemistry Hibiscus sabdariffa Humans Hydrogen-Ion Concentration Influenza Influenza A Influenza A virus - drug effects Influenza A virus - growth & development Influenza, Human - drug therapy Influenza, Human - virology Intranasal administration Mice Mice, Inbred BALB C Original Paper pH effects Plant Extracts - administration & dosage Plant Extracts - chemistry Protein structure Protocatechuic acid Roselle Tea Therapy Vaccination Vaccines Virology Viruses Natural substance Anti-human influenza A viral activity Antiviral drug therapy Acidic pH Hibiscus tea extract Whole inactivated vaccine
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