Long pentraxin PTX3 is upregulated systemically and centrally after experimental neurotrauma, but its depletion leaves unaltered sensorimotor deficits or histopathology

Long pentraxin PTX3, a pattern recognition molecule involved in innate immune responses, is upregulated by pro-inflammatory stimuli, contributors to secondary damage in traumatic brain injury (TBI). We analyzed PTX3 involvement in mice subjected to controlled cortical impact, a clinically relevant T...

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Bibliographic Details
Published in:	Scientific reports Vol. 11; no. 1; p. 9616
Main Authors:	Oggioni, Marco, Mercurio, Domenico, Minuta, Denise, Fumagalli, Stefano, Popiolek-Barczyk, Katarzyna, Sironi, Marina, Ciechanowska, Agata, Ippati, Stefania, De Blasio, Daiana, Perego, Carlo, Mika, Joanna, Garlanda, Cecilia, De Simoni, Maria-Grazia
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 05-05-2021 Nature Publishing Group Nature Portfolio
Subjects:	631/250/256/2515 631/250/256/2516 631/378/371 Amyloid Animals Brain - metabolism Brain Injuries - genetics Brain Injuries - metabolism Brain Injuries - pathology C-reactive protein C-Reactive Protein - genetics C-Reactive Protein - metabolism Collagen Collagen - metabolism Disease Models, Animal Fibrin Gliosis Histopathology Humanities and Social Sciences Immune response Inflammation Inflammation - metabolism Inflammation - pathology Innate immunity Leukocytes (neutrophilic) Male Mice Microglia mRNA multidisciplinary Neurons - metabolism Neurons - pathology Neutrophils Neutrophils - metabolism Pattern recognition Pentraxins Phagocytosis Phenotypes Proteins SAP protein Science Science (multidisciplinary) Sensorimotor system Serum Amyloid P-Component - genetics Serum Amyloid P-Component - metabolism Traumatic brain injury Up-Regulation
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