WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion

WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion

Melanoma is a highly aggressive tumour that can metastasize very early in disease progression. Notably, melanoma can disseminate using amoeboid invasive strategies. We show here that high Myosin II activity, high levels of ki-67 and high tumour-initiating abilities are characteristic of invasive amo...

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Published in:Nature communications Vol. 11; no. 1; pp. 5315 - 20
Main Authors: Rodriguez-Hernandez, Irene, Maiques, Oscar, Kohlhammer, Leonie, Cantelli, Gaia, Perdrix-Rosell, Anna, Monger, Joanne, Fanshawe, Bruce, Bridgeman, Victoria L., Karagiannis, Sophia N., Penin, Rosa M., Marcolval, Joaquim, Marti, Rosa M., Matias-Guiu, Xavier, Fruhwirth, Gilbert O., Orgaz, Jose L., Malanchi, Ilaria, Sanz-Moreno, Victoria
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 20-10-2020
Nature Publishing Group
Nature Portfolio
Subjects:
13/1
13/105
13/106
13/51
13/89
13/95
14
14/19
38
38/77
631/67/1813/1634
631/67/71
631/80/86/2341
Animals
Cell Transformation, Neoplastic
Female
Frizzled Receptors - genetics
Frizzled Receptors - metabolism
Humanities and Social Sciences
Humans
Male
Melanoma
Melanoma - genetics
Melanoma - metabolism
Melanoma - pathology
Metastases
Metastasis
Mice
Mice, SCID
Microfilament Proteins - genetics
Microfilament Proteins - metabolism
multidisciplinary
Myosin
Myosin Type II - genetics
Myosin Type II - metabolism
Neoplasm Invasiveness
rho GTP-Binding Proteins - genetics
rho GTP-Binding Proteins - metabolism
rho-Associated Kinases - genetics
rho-Associated Kinases - metabolism
Science
Science (multidisciplinary)
Signal Transduction
Tumors
Wnt Proteins - genetics
Wnt Proteins - metabolism
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Abstract Melanoma is a highly aggressive tumour that can metastasize very early in disease progression. Notably, melanoma can disseminate using amoeboid invasive strategies. We show here that high Myosin II activity, high levels of ki-67 and high tumour-initiating abilities are characteristic of invasive amoeboid melanoma cells. Mechanistically, we find that WNT11-FZD7-DAAM1 activates Rho-ROCK1/2-Myosin II and plays a crucial role in regulating tumour-initiating potential, local invasion and distant metastasis formation. Importantly, amoeboid melanoma cells express both proliferative and invasive gene signatures. As such, invasive fronts of human and mouse melanomas are enriched in amoeboid cells that are also ki-67 positive. This pattern is further enhanced in metastatic lesions. We propose eradication of amoeboid melanoma cells after surgical removal as a therapeutic strategy. Amoeboid cells are associated with melanoma invasive capacity. Here, the authors show that the WNT11-FZD7-DAAM1 pathway regulates tumour-initiating potential, invasion and metastasis lead by amoeboid cells in the invasive front of melanoma tumours.
AbstractList Melanoma is a highly aggressive tumour that can metastasize very early in disease progression. Notably, melanoma can disseminate using amoeboid invasive strategies. We show here that high Myosin II activity, high levels of ki-67 and high tumour-initiating abilities are characteristic of invasive amoeboid melanoma cells. Mechanistically, we find that WNT11-FZD7-DAAM1 activates Rho-ROCK1/2-Myosin II and plays a crucial role in regulating tumour-initiating potential, local invasion and distant metastasis formation. Importantly, amoeboid melanoma cells express both proliferative and invasive gene signatures. As such, invasive fronts of human and mouse melanomas are enriched in amoeboid cells that are also ki-67 positive. This pattern is further enhanced in metastatic lesions. We propose eradication of amoeboid melanoma cells after surgical removal as a therapeutic strategy. Amoeboid cells are associated with melanoma invasive capacity. Here, the authors show that the WNT11-FZD7-DAAM1 pathway regulates tumour-initiating potential, invasion and metastasis lead by amoeboid cells in the invasive front of melanoma tumours.
Amoeboid cells are associated with melanoma invasive capacity. Here, the authors show that the WNT11-FZD7-DAAM1 pathway regulates tumour-initiating potential, invasion and metastasis lead by amoeboid cells in the invasive front of melanoma tumours.
Melanoma is a highly aggressive tumour that can metastasize very early in disease progression. Notably, melanoma can disseminate using amoeboid invasive strategies. We show here that high Myosin II activity, high levels of ki-67 and high tumour-initiating abilities are characteristic of invasive amoeboid melanoma cells. Mechanistically, we find that WNT11-FZD7-DAAM1 activates Rho-ROCK1/2-Myosin II and plays a crucial role in regulating tumour-initiating potential, local invasion and distant metastasis formation. Importantly, amoeboid melanoma cells express both proliferative and invasive gene signatures. As such, invasive fronts of human and mouse melanomas are enriched in amoeboid cells that are also ki-67 positive. This pattern is further enhanced in metastatic lesions. We propose eradication of amoeboid melanoma cells after surgical removal as a therapeutic strategy.
Melanoma is a highly aggressive tumour that can metastasize very early in disease progression. Notably, melanoma can disseminate using amoeboid invasive strategies. We show here that high Myosin II activity, high levels of ki-67 and high tumour-initiating abilities are characteristic of invasive amoeboid melanoma cells. Mechanistically, we find that WNT11-FZD7-DAAM1 activates Rho-ROCK1/2-Myosin II and plays a crucial role in regulating tumour-initiating potential, local invasion and distant metastasis formation. Importantly, amoeboid melanoma cells express both proliferative and invasive gene signatures. As such, invasive fronts of human and mouse melanomas are enriched in amoeboid cells that are also ki-67 positive. This pattern is further enhanced in metastatic lesions. We propose eradication of amoeboid melanoma cells after surgical removal as a therapeutic strategy.Amoeboid cells are associated with melanoma invasive capacity. Here, the authors show that the WNT11-FZD7-DAAM1 pathway regulates tumour-initiating potential, invasion and metastasis lead by amoeboid cells in the invasive front of melanoma tumours.
ArticleNumber 5315
Author Rodriguez-Hernandez, Irene
Penin, Rosa M.
Perdrix-Rosell, Anna
Sanz-Moreno, Victoria
Fanshawe, Bruce
Marti, Rosa M.
Karagiannis, Sophia N.
Cantelli, Gaia
Kohlhammer, Leonie
Maiques, Oscar
Malanchi, Ilaria
Matias-Guiu, Xavier
Orgaz, Jose L.
Monger, Joanne
Bridgeman, Victoria L.
Marcolval, Joaquim
Fruhwirth, Gilbert O.
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  orcidid: 0000-0002-4100-7810
  surname: Karagiannis
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  organization: Barts Cancer Institute, Queen Mary University of London, John Vane Science Building, Charterhouse Square, Randall Division of Cell and Molecular Biophysics, New Hunt’s House, Guy’s Campus, King’s College London, Instituto de Investigaciones Biomedicas ‘Alberto Sols’, CSIC-UAM
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  email: v.sanz-moreno@qmul.ac.uk
  organization: Barts Cancer Institute, Queen Mary University of London, John Vane Science Building, Charterhouse Square, Randall Division of Cell and Molecular Biophysics, New Hunt’s House, Guy’s Campus, King’s College London
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33082334$$D View this record in MEDLINE/PubMed
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SSID ssj0000391844
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Snippet Melanoma is a highly aggressive tumour that can metastasize very early in disease progression. Notably, melanoma can disseminate using amoeboid invasive...
Amoeboid cells are associated with melanoma invasive capacity. Here, the authors show that the WNT11-FZD7-DAAM1 pathway regulates tumour-initiating potential,...
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pubmedcentral
proquest
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Open Access Repository
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Index Database
Publisher
StartPage 5315
SubjectTerms 13/1
13/105
13/106
13/51
13/89
13/95
14
14/19
38
38/77
631/67/1813/1634
631/67/71
631/80/86/2341
Animals
Cell Transformation, Neoplastic
Female
Frizzled Receptors - genetics
Frizzled Receptors - metabolism
Humanities and Social Sciences
Humans
Male
Melanoma
Melanoma - genetics
Melanoma - metabolism
Melanoma - pathology
Metastases
Metastasis
Mice
Mice, SCID
Microfilament Proteins - genetics
Microfilament Proteins - metabolism
multidisciplinary
Myosin
Myosin Type II - genetics
Myosin Type II - metabolism
Neoplasm Invasiveness
rho GTP-Binding Proteins - genetics
rho GTP-Binding Proteins - metabolism
rho-Associated Kinases - genetics
rho-Associated Kinases - metabolism
Science
Science (multidisciplinary)
Signal Transduction
Tumors
Wnt Proteins - genetics
Wnt Proteins - metabolism
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Title WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion
URI https://link.springer.com/article/10.1038/s41467-020-18951-2
https://www.ncbi.nlm.nih.gov/pubmed/33082334
https://www.proquest.com/docview/2471472243
https://pubmed.ncbi.nlm.nih.gov/PMC7575593
https://doaj.org/article/9e4929d31dc4466f83996eb59f8cabaf
Volume 11
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