Nephrotoxicity evaluation and proteomic analysis in kidneys of rats exposed to thioacetamide

Thioacetamide (TAA) was administered orally at 0, 10, and 30 mg/kg body weight (BW) daily to Sprague–Dawley rats aged 6–7 weeks for 28 consecutive days. Nephrotoxicity and proteomics were evaluated in the kidneys of rats exposed to TAA. The BW decreased, however, the relative kidneys weight increase...

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Bibliographic Details
Published in:	Scientific reports Vol. 12; no. 1; p. 6837
Main Authors:	Lim, Ji-youn, Jung, Woon-Won, Kim, Woojin, Moon, Kyoung-Sik, Sul, Donggeun
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 27-04-2022 Nature Publishing Group Nature Portfolio
Subjects:	631/45 631/61 Animals Biomarkers Blood Body weight Gene expression Hematocrit Hematology Hemoglobin Humanities and Social Sciences Isoforms Kidney Kidneys Liver Liver - metabolism Mass spectrometry Monocytes multidisciplinary Oral administration Proteins Proteomics Rats Rats, Sprague-Dawley RGS Proteins - metabolism Science Science (multidisciplinary) Scientific imaging Thioacetamide Thioacetamide - toxicity Toxicology Urine
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