A mouse model of autism implicates endosome pH in the regulation of presynaptic calcium entry

Psychoactive compounds such as chloroquine and amphetamine act by dissipating the pH gradient across intracellular membranes, but the physiological mechanisms that normally regulate organelle pH remain poorly understood. Interestingly, recent human genetic studies have implicated the endosomal Na +...

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Bibliographic Details
Published in:	Nature communications Vol. 9; no. 1; pp. 330 - 18
Main Authors:	Ullman, Julie C., Yang, Jing, Sullivan, Michael, Bendor, Jacob, Levy, Jonathan, Pham, Ellen, Silm, Katlin, Seifikar, Helia, Sohal, Vikaas S., Nicoll, Roger A., Edwards, Robert H.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 23-01-2018 Nature Publishing Group Nature Portfolio
Subjects:	13/106 13/109 14 14/19 38/39 631/378/1689/1373 631/378/87 64/60 9/26 9/30 9/74 Acidification Amphetamines Animals Attention Deficit Disorder with Hyperactivity - genetics Attention Deficit Disorder with Hyperactivity - metabolism Attention Deficit Disorder with Hyperactivity - physiopathology Attention deficit hyperactivity disorder Autism Autism Spectrum Disorder - genetics Autism Spectrum Disorder - metabolism Autism Spectrum Disorder - physiopathology Behavior, Animal Calcium Calcium - metabolism Calcium compounds Calcium influx Chloroquine Deactivation Defects Disease Models, Animal Electroencephalography Endosomes Endosomes - metabolism Endosomes - pathology Female Gene Expression Glutamic Acid - metabolism Glutamic acid receptors Hippocampus - metabolism Hippocampus - physiopathology Humanities and Social Sciences Humans Hydrogen ions Hydrogen-Ion Concentration Inactivation Information processing Intracellular Isoforms Male Membranes Mice Mice, Knockout multidisciplinary Na+/H+-exchanging ATPase Neurons - metabolism Neurons - pathology Neurotransmitter release pH effects Physiology Presynaptic Terminals - metabolism Presynaptic Terminals - pathology Primary Cell Culture Science Science (multidisciplinary) Sensory integration Sodium-Hydrogen Exchangers - deficiency Sodium-Hydrogen Exchangers - genetics Synaptic Transmission - physiology Synaptic Vesicles - metabolism Synaptic Vesicles - pathology
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