Microcephalin 1/BRIT1-TRF2 interaction promotes telomere replication and repair, linking telomere dysfunction to primary microcephaly

Telomeres protect chromosome ends from inappropriately activating the DNA damage and repair responses. Primary microcephaly is a key clinical feature of several human telomere disorder syndromes, but how microcephaly is linked to dysfunctional telomeres is not known. Here, we show that the microceph...

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Bibliographic Details
Published in:	Nature communications Vol. 11; no. 1; p. 5861
Main Authors:	Cicconi, Alessandro, Rai, Rekha, Xiong, Xuexue, Broton, Cayla, Al-Hiyasat, Amer, Hu, Chunyi, Dong, Siying, Sun, Wenqi, Garbarino, Jennifer, Bindra, Ranjit S., Schildkraut, Carl, Chen, Yong, Chang, Sandy
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 17-11-2020 Nature Publishing Group Nature Portfolio
Subjects:	13/89 631/337 631/337/103/560 631/378 64/60 Aminopeptidases - genetics Aminopeptidases - metabolism Animals Binding Sites Calorimetry Cell Cycle Proteins - chemistry Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Chromosomes Crystal defects Crystal structure Cytoskeletal Proteins - chemistry Cytoskeletal Proteins - genetics Cytoskeletal Proteins - metabolism Damage localization Deoxyribonucleic acid Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - genetics Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - metabolism Disorders DNA DNA Damage DNA repair Fibroblasts HeLa Cells Histones - genetics Histones - metabolism Homology Humanities and Social Sciences Humans Localization Mice Microcephaly Microcephaly - genetics Microencephaly multidisciplinary Mutation Protein Interaction Domains and Motifs Protein structure Proteins Repair Replication Replication forks Science Science (multidisciplinary) Serine Proteases - genetics Serine Proteases - metabolism Shelterin Complex Telomerase Telomerase reverse transcriptase Telomere - genetics Telomere - metabolism Telomere-binding protein Telomere-Binding Proteins - genetics Telomere-Binding Proteins - metabolism Telomeres Telomeric Repeat Binding Protein 2 - chemistry Telomeric Repeat Binding Protein 2 - genetics Telomeric Repeat Binding Protein 2 - metabolism TRF2 protein Yeast
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