Feature-tracking myocardial strain in healthy adults- a magnetic resonance study at 3.0 tesla

• Published in: Scientific reports Vol. 9; no. 1; p. 3239
• Main Authors: Mangion, Kenneth, Burke, Nicole M. M., McComb, Christie, Carrick, David, Woodward, Rosemary, Berry, Colin
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01-03-2019; Nature Publishing Group
• Subjects: 59/57; 631/114/1564; 692/4019/592; Adult; Aging; Aging - physiology; Bias; Cardiovascular diseases; Ejection fraction; FDA approval; Female; Females; Gadolinium; Health; Heart - diagnostic imaging; Heart - physiology; Humanities and Social Sciences; Humans; Magnetic Resonance Imaging; Male; multidisciplinary; Myocardium; Observer Variation; Reproducibility; Reproducibility of Results; Science; Science (multidisciplinary); Sex Characteristics; Standard deviation; Ventricular Function - physiology; Volunteers
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-019-39807-w

We analyzed feature-tracking derived circumferential and longitudinal strain in healthy volunteers who underwent cardiac magnetic resonance imaging (CMR) at 3.0 T. 88 healthy adults (44.6 ± 18.0 years old, 49% male), without prior cardiovascular disease, underwent CMR at 3.0 T including cine, and late gadolinium enhancement in subjects >45 years. LV functional analysis and feature-tracking strain analyses were carried out. Global strain had better reproducibility than segmental strain. There was a sex specific difference global longitudinal strain (mean ± SD, −18.48 ± 3.65% (male), −21.91 ± 3.01% (female), p < 0.001), but not global circumferential strain (mean ± SD, −25.41 ± 4.50% (male), −27.94 ± 3.48% (female), p = 0.643). There was no association of strain with ageing after accounting for sex for both global longitudinal and circumferential strain. Feature-tracking strain analysis is feasible at 3.0 T. Healthy female volunteers demonstrated higher magnitudes of global longitudinal strain when compared to male counterparts. Whilst global cine-strain has good reproducibility, segmental strain does not.