Wnt-β Catenin Signaling Pathway: A Major Player in the Injury Induced Fibrosis and Dysfunction of the External Anal Sphincter

Wnt-β catenin is an important signaling pathway in the genesis of fibrosis in many organ systems. Our goal was to examine the role of Wnt pathway in the external anal sphincter (EAS) injury-related fibrosis and muscle dysfunction. New Zealand White female rabbits were subjected to surgical EAS myoto...

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Bibliographic Details
Published in:	Scientific reports Vol. 7; no. 1; pp. 963 - 9
Main Authors:	Rajasekaran, M. Raj, Kanoo, Sadhana, Fu, Johnny, Bhargava, Valmik, Mittal, Ravinder K.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 19-04-2017 Nature Publishing Group Nature Portfolio
Subjects:	38 38/77 692/4020/1503 692/4020/1503/2753/1487 82/51 Animals Anus Catenin Collagen Connective tissue Fecal incontinence Fibrosis Growth factors Humanities and Social Sciences Injuries multidisciplinary Pressure Science Science (multidisciplinary) Signal transduction Sphincter Transforming growth factor Transforming growth factor-b Vagina Wnt protein Womens health
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