Identifying potential novel drugs against Helicobacter pylori by targeting the essential response regulator HsrA

The increasing antibiotic resistance evolved by Helicobacter pylori has alarmingly reduced the eradication rates of first-line therapies. To overcome the current circulating resistome, we selected a novel potential therapeutic target in order to identify new candidate drugs for treating H . pylori i...

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Bibliographic Details
Published in:	Scientific reports Vol. 9; no. 1; pp. 11294 - 13
Main Authors:	González, Andrés, Salillas, Sandra, Velázquez-Campoy, Adrián, Espinosa Angarica, Vladimir, Fillat, María F., Sancho, Javier, Lanas, Ángel
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 05-08-2019 Nature Publishing Group
Subjects:	119/118 631/154/1435/2163 631/92/507 82/16 82/29 82/80 82/83 Amino acids Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibiotic resistance Bacterial Proteins - antagonists & inhibitors Bacterial Proteins - metabolism Bactericidal activity Binders Clarithromycin Deoxyribonucleic acid DNA Drug development Drug Discovery Drugs Eradication Flavonoids Flavonoids - chemistry Flavonoids - pharmacology Helicobacter Infections - drug therapy Helicobacter Infections - microbiology Helicobacter pylori Helicobacter pylori - drug effects Helicobacter pylori - metabolism Hesperidin Humanities and Social Sciences Humans Kaempferol Metronidazole Molecular Docking Simulation multidisciplinary Science Science (multidisciplinary) Synergistic effect Therapeutic applications
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