Fructose-1,6-bisphosphate preserves intracellular glutathione and protects cortical neurons against oxidative stress

Fructose-1,6-bisphosphate (FBP), an endogenous intermediate of glycolysis, protects the brain against ischemia–reperfusion injury. The mechanisms of FBP protection after cerebral ischemia are not well understood. The current study was undertaken to determine whether FBP protects primary neurons agai...

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Bibliographic Details
Published in:	Brain research Vol. 960; no. 1; pp. 90 - 98
Main Authors:	Vexler, Zinaida S., Wong, Arthur, Francisco, Carla, Manabat, Catherine, Christen, Stephan, Täuber, Martin, Ferriero, Donna M., Gregory, George
Format:	Journal Article
Language:	English
Published:	London Elsevier B.V 17-01-2003 Amsterdam Elsevier New York, NY
Subjects:	6-Bisphosphate Animals Biological and medical sciences Buthionine Sulfoximine - pharmacology Carmustine - pharmacology Cell Hypoxia Cell Survival - drug effects Cells, Cultured Cerebral Cortex - cytology Cerebral Cortex - drug effects Cerebral Cortex - metabolism Enzyme Inhibitors - pharmacology Free Radicals - pharmacology Fructose-1 Fructosediphosphates - pharmacology Glutathione Glutathione - metabolism Glutathione Reductase - metabolism Hypoxia Intracellular Fluid - drug effects Intracellular Fluid - metabolism Medical sciences Mice Molsidomine - analogs & derivatives Molsidomine - pharmacology Neurons - drug effects Neurons - metabolism Neuropharmacology Neuroprotective agent Neuroprotective Agents Nitric Oxide - pharmacology Oxidation-Reduction Oxidative Stress - drug effects Pharmacology. Drug treatments Reactive oxygen species Tetrazolium Salts Thiazoles Disorders of the nervous system Hypoxia Reactive oxygen species 6-Bisphosphate Fructose-1 Glutathione Oxidative stress Oxygen Cerebral cortex Rodentia Central nervous system Environmental factor Neuroprotective agent Vertebrata Mammalia Mouse Animal Intracellular Brain (vertebrata)
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