The loss of DHX15 impairs endothelial energy metabolism, lymphatic drainage and tumor metastasis in mice

DHX15 is a downstream substrate for Akt1, which is involved in key cellular processes affecting vascular biology. Here, we explored the vascular regulatory function of DHX15. Homozygous DHX15 gene deficiency was lethal in mouse and zebrafish embryos. DHX15 —/— zebrafish also showed downregulation of...

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Bibliographic Details
Published in:	Communications biology Vol. 4; no. 1; p. 1192
Main Authors:	Ribera, Jordi, Portolés, Irene, Córdoba-Jover, Bernat, Rodríguez-Vita, Juan, Casals, Gregori, González-de la Presa, Bernardino, Graupera, Mariona, Solsona-Vilarrasa, Estel, Garcia-Ruiz, Carmen, Fernández-Checa, José C., Soria, Guadalupe, Tudela, Raúl, Esteve-Codina, Anna, Espadas, Guadalupe, Sabidó, Eduard, Jiménez, Wladimiro, Sessa, William C., Morales-Ruiz, Manuel
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 15-10-2021 Nature Publishing Group Nature Portfolio
Subjects:	13/51 42/41 42/44 42/89 59/57 631/337/1645/1792 631/80/86 64/110 64/116 64/60 82/29 82/58 82/80 96/1 96/106 96/109 96/31 96/34 96/47 96/95 AKT1 protein Animal models Animals Biology Biomedical and Life Sciences Danio rerio DNA helicase Electron transport chain Embryo, Mammalian - metabolism Embryo, Nonmammalian - embryology Embryo, Nonmammalian - metabolism Embryos Endothelial cells Endothelium - metabolism Energy Metabolism Life Sciences Lymphatic drainage Lymphatic System - pathology Metabolism Metastases Metastasis Mice Mice, Transgenic - embryology Mitochondria Neoplasm Metastasis Neoplasms Oxygen consumption Proteomes RNA helicase RNA Helicases - deficiency Tumor cells Vascular endothelial growth factor Zebrafish - embryology
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