Recurrent childhood anaplastic large cell lymphoma: a retrospective analysis of registered cases in Japan

• Published in: British journal of haematology Vol. 132; no. 5; pp. 594 - 597
• Main Authors: Mori, Tetsuya, Takimoto, Tetsuya, Katano, Naoyuki, Kikuchi, Akira, Tabuchi, Ken, Kobayashi, Ryoji, Ayukawa, Hiroshi, Kumagai, Masa‐aki, Horibe, Keizo, Tsurusawa, Masahito
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01-03-2006; Blackwell; Blackwell Publishing Ltd
• Subjects: Adolescent; allogenic bone marrow transplantation; anaplastic large cell lymphoma; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; autologous stem cell transplantation; Biological and medical sciences; Child; Child, Preschool; Disease Progression; Female; Follow-Up Studies; haematopoietic stem cell transplantation; Hematologic and hematopoietic diseases; Hematology; Hematopoietic Stem Cell Transplantation; Humans; Infant; Japan; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Lymphoma, Large-Cell, Anaplastic - drug therapy; Lymphoma, Large-Cell, Anaplastic - mortality; Lymphoma, Large-Cell, Anaplastic - surgery; Male; Medical sciences; Neoplasm Recurrence, Local - mortality; relapse; Remission Induction; Retrospective Studies; Survival Rate; Transplantation, Homologous; Treatment Outcome; Asia; Japan; Human; Relapse; Hematology; Stem cell; autologous stem cell transplantation; Hematopoietic cell; Homograft; Anaplastic cell lymphoma; Malignant hemopathy; Large cell lymphoma; Non Hodgkin lymphoma; haematopoietic stem cell transplantation; Retrospective; Case study; Autograft; allogenic bone marrow transplantation; Register; Lymphoproliferative syndrome; Bone marrow; Graft; anaplastic large cell lymphoma; Child
• ISSN: 0007-1048; 1365-2141
• DOI: 10.1111/j.1365-2141.2005.05910.x

Summary
This report presents a retrospective study of 26 Japanese children with recurrent anaplastic large cell lymphoma. The first relapses were documented at a median of 10·5 months after the initial diagnosis. Twenty‐four patients achieved a second remission. After a median follow‐up period of 47 months, 18 patients are still alive: 15 patients are in second complete remission (CR), three patients are in third CR or later. The 5 year overall and relapse‐free survival rates were 61 ± 12% and 51 ± 12% respectively. The patients who received allogeneic haematopoietic stem cell transplantation during second CR showed a superior outcome to other patients.