Kaempferol Interferes with Varicella-Zoster Virus Replication in Human Foreskin Fibroblasts

Kaempferol Interferes with Varicella-Zoster Virus Replication in Human Foreskin Fibroblasts

Kaempferol, a natural flavonoid abundantly found in plants, is known to have pharmacological properties, such as anti-inflammatory and anti-cancer effects. In this study, we investigated the antiviral effects of kaempferol against a varicella-zoster virus (VZV) clinical isolate in vitro. We found th...

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Published in:Pharmaceuticals (Basel, Switzerland) Vol. 15; no. 12; p. 1582
Main Authors: Park, Subin, Kim, Na-Eun, Park, Bang Ju, Kwon, Hak Cheol, Song, Yoon-Jae
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 01-12-2022
MDPI
Subjects:
antiviral
Bioflavonoids
Care and treatment
Chicken pox
Cytotoxicity
DNA polymerase
Encephalitis
Fibroblasts
Flavones
Flavonoids
Gene expression
Genetic aspects
Health aspects
Herpes
Herpesvirus diseases
Infections
Influenza
kaempferol
Kinases
Pharmacology, Experimental
Physiological aspects
Varicella-zoster virus
Viruses
South Korea
kaempferol
varicella-zoster virus
antiviral
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Abstract Kaempferol, a natural flavonoid abundantly found in plants, is known to have pharmacological properties, such as anti-inflammatory and anti-cancer effects. In this study, we investigated the antiviral effects of kaempferol against a varicella-zoster virus (VZV) clinical isolate in vitro. We found that kaempferol significantly inhibited VZV replication without exhibiting cytotoxicity. Kaempferol exerted its antiviral effect at a similar stage of the VZV life cycle as acyclovir, which inhibits VZV DNA replication. Taken together, our results suggest that kaempferol inhibits VZV infection by blocking the DNA replication stage in the viral life cycle.
AbstractList Kaempferol, a natural flavonoid abundantly found in plants, is known to have pharmacological properties, such as anti-inflammatory and anti-cancer effects. In this study, we investigated the antiviral effects of kaempferol against a varicella-zoster virus (VZV) clinical isolate in vitro. We found that kaempferol significantly inhibited VZV replication without exhibiting cytotoxicity. Kaempferol exerted its antiviral effect at a similar stage of the VZV life cycle as acyclovir, which inhibits VZV DNA replication. Taken together, our results suggest that kaempferol inhibits VZV infection by blocking the DNA replication stage in the viral life cycle.
Audience Academic
Author Kwon, Hak Cheol
Kim, Na-Eun
Park, Bang Ju
Song, Yoon-Jae
Park, Subin
AuthorAffiliation 3 Natural Product Informatics Research Center, Korea Institute of Science and Technology (KIST), Gangneung Institute, Gangneung 25451, Republic of Korea
1 Department of Life Science, Gachon University, Seongnam-si 13120, Republic of Korea
2 Department of Electronic Engineering, Gachon University, Seongnam-si 13120, Republic of Korea
AuthorAffiliation_xml – name: 3 Natural Product Informatics Research Center, Korea Institute of Science and Technology (KIST), Gangneung Institute, Gangneung 25451, Republic of Korea
– name: 2 Department of Electronic Engineering, Gachon University, Seongnam-si 13120, Republic of Korea
– name: 1 Department of Life Science, Gachon University, Seongnam-si 13120, Republic of Korea
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  surname: Park
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  organization: Department of Life Science, Gachon University, Seongnam-si 13120, Republic of Korea
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  givenname: Na-Eun
  surname: Kim
  fullname: Kim, Na-Eun
  organization: Department of Life Science, Gachon University, Seongnam-si 13120, Republic of Korea
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/36559033$$D View this record in MEDLINE/PubMed
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Issue 12
Keywords kaempferol
varicella-zoster virus
antiviral
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  doi: 10.3389/fmicb.2021.736780
  contributor:
    fullname: Arabyan
SSID ssj0057141
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Snippet Kaempferol, a natural flavonoid abundantly found in plants, is known to have pharmacological properties, such as anti-inflammatory and anti-cancer effects. In...
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StartPage 1582
SubjectTerms antiviral
Bioflavonoids
Care and treatment
Chicken pox
Cytotoxicity
DNA polymerase
Encephalitis
Fibroblasts
Flavones
Flavonoids
Gene expression
Genetic aspects
Health aspects
Herpes
Herpesvirus diseases
Infections
Influenza
kaempferol
Kinases
Pharmacology, Experimental
Physiological aspects
Varicella-zoster virus
Viruses
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Title Kaempferol Interferes with Varicella-Zoster Virus Replication in Human Foreskin Fibroblasts
URI https://www.ncbi.nlm.nih.gov/pubmed/36559033
https://www.proquest.com/docview/2756778285
https://search.proquest.com/docview/2758105026
https://pubmed.ncbi.nlm.nih.gov/PMC9788135
https://doaj.org/article/1dc8805f833e42959d81dab01d7ffd5f
Volume 15
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