Mucosal HIV-1 transmission and prevention strategies in BLT humanized mice

Clinical trials testing microbicides and related biomedical interventions to block HIV transmissions have produced contradictory results and to date it is unclear why. Further elucidation of the molecular basis of mucosal HIV transmission and extensive pharmacokinetic and pharmacodynamic analyses ar...

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Bibliographic Details
Published in:	Trends in microbiology (Regular ed.) Vol. 20; no. 6; pp. 268 - 274
Main Authors:	Denton, Paul W, Garcia, J. Victor
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-06-2012
Subjects:	Animals BLT Disease Models, Animal Disinfectants - administration & dosage efficacy evaluation HIV Infections - immunology HIV Infections - prevention & control HIV Infections - transmission HIV Infections - virology HIV-1 - immunology HIV-1 - isolation & purification HIV-1 prevention Human immunodeficiency virus Human immunodeficiency virus 1 humanized mice Humans Immunity, Mucosal Internal Medicine Mice Mice, SCID Mice, Transgenic microbicides Mucous Membrane - virology PrEP Treatment Outcome HIV-1 prevention BLT PrEP microbicides humanized mice efficacy evaluation
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