The Effects of Hydrogen-Rich Water on Blood Lipid Profiles in Clinical Populations: A Systematic Review and Meta-Analysis

Over the last two decades, a plethora of disease models and human studies have confirmed the beneficial effects of molecular hydrogen (H ), a simple biotherapeutic gas. Recent small-scale studies evaluating the effects of hydrogen-rich water (HRW) on various metabolic conditions pointed to advantage...

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Published in:	Pharmaceuticals (Basel, Switzerland) Vol. 16; no. 2; p. 142
Main Authors:	Todorovic, Nikola, Fernández-Landa, Julen, Santibañez, Asier, Kura, Branislav, Stajer, Valdemar, Korovljev, Darinka, Ostojic, Sergej M
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 18-01-2023 MDPI
Subjects:	Asymmetry Bias Blood lipids Body fat Care and treatment Chemical properties Cholesterol Disease Drinking water Gene expression Health aspects High density lipoprotein Homeostasis Hydrogen hydrogen-rich water Lipids Lipoproteins Meta-analysis Metabolic diseases Metabolic syndrome molecular hydrogen Obesity Older people Population Risk factors Systematic Review Triglycerides Serbia metabolic syndrome lipids triglycerides hydrogen-rich water molecular hydrogen
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Abstract	Over the last two decades, a plethora of disease models and human studies have confirmed the beneficial effects of molecular hydrogen (H ), a simple biotherapeutic gas. Recent small-scale studies evaluating the effects of hydrogen-rich water (HRW) on various metabolic conditions pointed to advantageous effects of HRW in regulating blood lipid profiles. However, to the best of the authors' knowledge, no systematic review and/or meta-analysis (SRMA) were published considering HRW consumption and lipid/lipoprotein status. Therefore, the aim of this SRMA was to assess the effects of HRW consumption on blood lipid panel in clinical populations. The search strategy was designed using PRISMA guidelines, and the databases PubMed/Medline, Web of Science, and Scopus were explored from inception until 4 October 2022. A total of seven studies satisfied all the eligibility criteria and were included in SRMA. The results for the pooled meta-analysis showed a significant reduction in total cholesterol, low-density lipoprotein, and triglycerides after HRW intake ( = 0.01), with small to moderate effects (pooled SMD = -0.23 (from -0.40 to 0.05); pooled SMD = -0.22 (from -0.39 to 0.04); pooled SMD = -0.38 (from -0.59 to 0.18), respectively). Our findings indicate that drinking HRW can significantly improve lipid status in the clinical populations. Additional studies are warranted to further validate this connection.
AbstractList	Over the last two decades, a plethora of disease models and human studies have confirmed the beneficial effects of molecular hydrogen (H2), a simple biotherapeutic gas. Recent small-scale studies evaluating the effects of hydrogen-rich water (HRW) on various metabolic conditions pointed to advantageous effects of HRW in regulating blood lipid profiles. However, to the best of the authors’ knowledge, no systematic review and/or meta-analysis (SRMA) were published considering HRW consumption and lipid/lipoprotein status. Therefore, the aim of this SRMA was to assess the effects of HRW consumption on blood lipid panel in clinical populations. The search strategy was designed using PRISMA guidelines, and the databases PubMed/Medline, Web of Science, and Scopus were explored from inception until 4 October 2022. A total of seven studies satisfied all the eligibility criteria and were included in SRMA. The results for the pooled meta-analysis showed a significant reduction in total cholesterol, low-density lipoprotein, and triglycerides after HRW intake (p = 0.01), with small to moderate effects (pooled SMD = −0.23 (from −0.40 to 0.05); pooled SMD = −0.22 (from −0.39 to 0.04); pooled SMD = −0.38 (from −0.59 to 0.18), respectively). Our findings indicate that drinking HRW can significantly improve lipid status in the clinical populations. Additional studies are warranted to further validate this connection. Over the last two decades, a plethora of disease models and human studies have confirmed the beneficial effects of molecular hydrogen (H[sub.2] ), a simple biotherapeutic gas. Recent small-scale studies evaluating the effects of hydrogen-rich water (HRW) on various metabolic conditions pointed to advantageous effects of HRW in regulating blood lipid profiles. However, to the best of the authors’ knowledge, no systematic review and/or meta-analysis (SRMA) were published considering HRW consumption and lipid/lipoprotein status. Therefore, the aim of this SRMA was to assess the effects of HRW consumption on blood lipid panel in clinical populations. The search strategy was designed using PRISMA guidelines, and the databases PubMed/Medline, Web of Science, and Scopus were explored from inception until 4 October 2022. A total of seven studies satisfied all the eligibility criteria and were included in SRMA. The results for the pooled meta-analysis showed a significant reduction in total cholesterol, low-density lipoprotein, and triglycerides after HRW intake (p = 0.01), with small to moderate effects (pooled SMD = −0.23 (from −0.40 to 0.05); pooled SMD = −0.22 (from −0.39 to 0.04); pooled SMD = −0.38 (from −0.59 to 0.18), respectively). Our findings indicate that drinking HRW can significantly improve lipid status in the clinical populations. Additional studies are warranted to further validate this connection. Over the last two decades, a plethora of disease models and human studies have confirmed the beneficial effects of molecular hydrogen (H ), a simple biotherapeutic gas. Recent small-scale studies evaluating the effects of hydrogen-rich water (HRW) on various metabolic conditions pointed to advantageous effects of HRW in regulating blood lipid profiles. However, to the best of the authors' knowledge, no systematic review and/or meta-analysis (SRMA) were published considering HRW consumption and lipid/lipoprotein status. Therefore, the aim of this SRMA was to assess the effects of HRW consumption on blood lipid panel in clinical populations. The search strategy was designed using PRISMA guidelines, and the databases PubMed/Medline, Web of Science, and Scopus were explored from inception until 4 October 2022. A total of seven studies satisfied all the eligibility criteria and were included in SRMA. The results for the pooled meta-analysis showed a significant reduction in total cholesterol, low-density lipoprotein, and triglycerides after HRW intake ( = 0.01), with small to moderate effects (pooled SMD = -0.23 (from -0.40 to 0.05); pooled SMD = -0.22 (from -0.39 to 0.04); pooled SMD = -0.38 (from -0.59 to 0.18), respectively). Our findings indicate that drinking HRW can significantly improve lipid status in the clinical populations. Additional studies are warranted to further validate this connection. Over the last two decades, a plethora of disease models and human studies have confirmed the beneficial effects of molecular hydrogen (H 2 ), a simple biotherapeutic gas. Recent small-scale studies evaluating the effects of hydrogen-rich water (HRW) on various metabolic conditions pointed to advantageous effects of HRW in regulating blood lipid profiles. However, to the best of the authors’ knowledge, no systematic review and/or meta-analysis (SRMA) were published considering HRW consumption and lipid/lipoprotein status. Therefore, the aim of this SRMA was to assess the effects of HRW consumption on blood lipid panel in clinical populations. The search strategy was designed using PRISMA guidelines, and the databases PubMed/Medline, Web of Science, and Scopus were explored from inception until 4 October 2022. A total of seven studies satisfied all the eligibility criteria and were included in SRMA. The results for the pooled meta-analysis showed a significant reduction in total cholesterol, low-density lipoprotein, and triglycerides after HRW intake ( p = 0.01), with small to moderate effects (pooled SMD = −0.23 (from −0.40 to 0.05); pooled SMD = −0.22 (from −0.39 to 0.04); pooled SMD = −0.38 (from −0.59 to 0.18), respectively). Our findings indicate that drinking HRW can significantly improve lipid status in the clinical populations. Additional studies are warranted to further validate this connection.
Audience	Academic
Author	Santibañez, Asier Korovljev, Darinka Kura, Branislav Ostojic, Sergej M Todorovic, Nikola Stajer, Valdemar Fernández-Landa, Julen
AuthorAffiliation	1 Applied Bioenergetics Lab, Faculty of Sport and Physical Education, University of Novi Sad, 21000 Novi Sad, Serbia 5 Faculty of Health Sciences, University of Pecs, 7601 Pecs, Hungary 2 Physical Education and Sports Department, Faculty of Education and Sport, University of the Basque Country (UPV/EHU), 01007 Vitoria, Spain 3 Centre of Experimental Medicine, Institute for Heart Research, Slovak Academy of Sciences, 841 04 Bratislava, Slovakia 4 Department of Nutrition and Public Health, University of Agder, Universitetsveien 25, 4604 Kristiansand, Norway
AuthorAffiliation_xml	– name: 2 Physical Education and Sports Department, Faculty of Education and Sport, University of the Basque Country (UPV/EHU), 01007 Vitoria, Spain – name: 4 Department of Nutrition and Public Health, University of Agder, Universitetsveien 25, 4604 Kristiansand, Norway – name: 1 Applied Bioenergetics Lab, Faculty of Sport and Physical Education, University of Novi Sad, 21000 Novi Sad, Serbia – name: 3 Centre of Experimental Medicine, Institute for Heart Research, Slovak Academy of Sciences, 841 04 Bratislava, Slovakia – name: 5 Faculty of Health Sciences, University of Pecs, 7601 Pecs, Hungary
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Keywords	metabolic syndrome lipids triglycerides hydrogen-rich water molecular hydrogen
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Snippet	Over the last two decades, a plethora of disease models and human studies have confirmed the beneficial effects of molecular hydrogen (H ), a simple... Over the last two decades, a plethora of disease models and human studies have confirmed the beneficial effects of molecular hydrogen (H2), a simple... Over the last two decades, a plethora of disease models and human studies have confirmed the beneficial effects of molecular hydrogen (H[sub.2] ), a simple... Over the last two decades, a plethora of disease models and human studies have confirmed the beneficial effects of molecular hydrogen (H 2 ), a simple...
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SubjectTerms	Asymmetry Bias Blood lipids Body fat Care and treatment Chemical properties Cholesterol Disease Drinking water Gene expression Health aspects High density lipoprotein Homeostasis Hydrogen hydrogen-rich water Lipids Lipoproteins Meta-analysis Metabolic diseases Metabolic syndrome molecular hydrogen Obesity Older people Population Risk factors Systematic Review Triglycerides
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Title	The Effects of Hydrogen-Rich Water on Blood Lipid Profiles in Clinical Populations: A Systematic Review and Meta-Analysis
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