The Use of Natural Fiber-Rich Food Product Is Safe and Reduces Aberrant Crypt Foci in a Pre-Clinical Model

Colorectal cancer is a highly prevalent disease, requiring effective strategies for prevention and treatment. The present research aimed to formulate a natural fiber-rich food product (NFRFP) and to evaluate its safety, toxicogenetics, and effects on aberrant crypt foci induced by 1,2-dimethyl-hydra...

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Bibliographic Details
Published in:	Nutrients Vol. 13; no. 8; p. 2708
Main Authors:	do Amaral, Luane Aparecida, da Silva Fleming de Almeida, Taina, Oliveira de Souza, Gabriel Henrique, Baranoski, Adrivanio, Souza Maris, Rafael, Bittencourt Junior, Felipe Francisco, Murino Rafacho, Bruna Paola, Duenhas Monreal, Antonio Carlos, Leite Kassuya, Cândida Aparecida, Milan Brochado Antoniolli-Silva, Andréia Conceição, Freitas Dos Santos, Elisvânia, Oliveira, Rodrigo Juliano
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 01-08-2021 MDPI
Subjects:	1,2-Dimethylhydrazine aberrant crypt foci Aberrant Crypt Foci - chemically induced Aberrant Crypt Foci - metabolism Aberrant Crypt Foci - pathology Aberrant Crypt Foci - prevention & control Agricultural industry Animal Feed Animal models Animals Cancer Carbohydrates Carcinogenicity Carcinogens chemoprevention Colon - metabolism Colon - pathology Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - chemically induced Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Colorectal Neoplasms - prevention & control Cytokines - blood Dietary fiber Dietary Fiber - administration & dosage dietary fibers Dimethylhydrazines Disease Models, Animal Ethylenediaminetetraacetic acid Food Food products functional foods Genotoxicity Health services Humidity Hydrazine Inflammation Inflammation Mediators - blood Lipids Male Microbiota Ostomy Prevention Proteins Rats Rats, Wistar Sensory properties Brazil United States aberrant crypt foci functional foods chemoprevention dietary fibers 1,2-dimethylhydrazine
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