Members of the IclR family of bacterial transcriptional regulators function as activators and/or repressors

Abstract Members of the IclR family of regulators are proteins with around 250 residues. The IclR family is best defined by a profile covering the effector binding domain. This is supported by structural data and by a number of mutants showing that effector specificity lies within a pocket in the C-...

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Bibliographic Details
Published in:	FEMS microbiology reviews Vol. 30; no. 2; pp. 157 - 186
Main Authors:	Molina-Henares, Antonio J., Krell, Tino, Eugenia Guazzaroni, Maria, Segura, Ana, Ramos, Juan L.
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01-03-2006 Blackwell Science Ltd Oxford University Press
Subjects:	Amino Acid Sequence Aromatic compounds Bacterial Proteins - chemistry Bacterial Proteins - physiology Binding sites Biodegradation catabolic pathways Cyclic AMP Receptor Protein - physiology Databases, Genetic Deactivation Deoxyribonucleic acid Dimers DNA DNA-directed RNA polymerase Erwinia - pathogenicity Escherichia coli Proteins - chemistry Escherichia coli Proteins - genetics Escherichia coli Proteins - physiology Gene Expression Regulation, Bacterial - genetics Glyoxylates - metabolism Helix-Turn-Helix Motifs - genetics IclR family Inactivation Krebs cycle control Molecular Sequence Data Multidrug resistance Pathogenicity Pathogens profiles Protein Structure, Secondary Protein Structure, Tertiary Proteins Regulators Repressor Proteins - chemistry Repressor Proteins - genetics Repressor Proteins - physiology Repressors Ribonucleic acid RNA RNA polymerase Sequence Homology, Amino Acid Shunt resistance solvent efflux pumps Sporulation Streptomyces - genetics Streptomyces - physiology Thermotoga maritima - genetics Transcription Transcription Factors - chemistry Transcription Factors - genetics Transcription Factors - physiology IclR family profiles solvent efflux pumps Krebs cycle control catabolic pathways sporulation
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