Rho-kinase/myosin light chain kinase pathway plays a key role in the impairment of bile canaliculi dynamics induced by cholestatic drugs

Intrahepatic cholestasis represents a frequent manifestation of drug-induced liver injury; however, the mechanisms underlying such injuries are poorly understood. In this study of human HepaRG and primary hepatocytes, we found that bile canaliculi (BC) underwent spontaneous contractions, which are e...

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Bibliographic Details
Published in:	Scientific reports Vol. 6; no. 1; p. 24709
Main Authors:	Sharanek, Ahmad, Burban, Audrey, Burbank, Matthew, Le Guevel, Rémy, Li, Ruoya, Guillouzo, André, Guguen-Guillouzo, Christiane
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 12-05-2016 Nature Publishing Group
Subjects:	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology 631/1647 631/1647/328 Bile Bile Acids and Salts - metabolism Bile Canaliculi - drug effects Bile Canaliculi - physiology Bile ducts Cardiac Myosins - metabolism Cell Survival - drug effects Cells, Cultured Chlorpromazine Chlorpromazine - pharmacology Cholestasis Cyclosporine - pharmacology Cyclosporins Deoxycholic acid Dephosphorylation Gallbladder diseases Hepatocytes Hepatocytes - cytology Hepatocytes - drug effects Hepatocytes - metabolism Human health and pathology Humanities and Social Sciences Humans Hépatology and Gastroenterology Isothiocyanate Life Sciences Liver Microscopy, Fluorescence multidisciplinary Myosin Myosin Light Chains - metabolism Myosin Type II - metabolism Myosin-light-chain kinase Myosin-Light-Chain Kinase - metabolism Pharmaceutical sciences Pharmacology Phosphorylation Phosphorylation - drug effects Rho-associated kinase rho-Associated Kinases - metabolism Rocks Science Signal Transduction - drug effects Time-Lapse Imaging Zonula Occludens-1 Protein - metabolism
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