The neutrophil to lymphocyte and platelet to lymphocyte ratios as biomarkers for lung cancer development

• Published in: Lung cancer (Amsterdam, Netherlands) Vol. 97; pp. 28 - 34
• Main Authors: Sanchez-Salcedo, Pablo, de-Torres, Juan P, Martinez-Urbistondo, Diego, Gonzalez-Gutierrez, Jessica, Berto, Juan, Campo, Arantzazu, Alcaide, Ana B, Zulueta, Javier J
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01-07-2016
• Subjects: Aged; Biomarkers; Early Detection of Cancer; Emphysema; Emphysema - diagnostic imaging; Emphysema - epidemiology; Female; Hematology, Oncology and Palliative Medicine; Humans; Incidence; Lung cancer; Lung cancer screening; Lung Neoplasms - diagnostic imaging; Lung Neoplasms - epidemiology; Lung Neoplasms - immunology; Lymphocyte Count; Male; Middle Aged; Neutrophil-to-lymphocyte ratio; Neutrophils; NLR; Platelet Count; Platelet-to-lymphocyte ratio; PLR; Predictive Value of Tests; Prevalence; Pulmonary Disease, Chronic Obstructive - pathology; Pulmonary/Respiratory; Risk Assessment; Spirometry; Tomography, X-Ray Computed - methods; GOLD; lung cancer screening; CBC; P-IELCAP; LDCT; Global initiative for chronic Obstructive Lung Disease; interquartile range; non-small cell lung carcinoma; Pamplona International Early Lung Cancer Action Program; emphysema; lung cancer; platelet-to-lymphocyte ratio; SD; neutrophil-to-lymphocyte ratio; NLR; PLR; NSCLC; CI; low-dose computed tomography; IQR; complete blood count; LC; confidence interval; COPD; chronic obstructive pulmonary disease; standard deviation; Neutrophil-to-lymphocyte ratio; Lung cancer; Lung cancer screening; Platelet-to-lymphocyte ratio; Emphysema
• ISSN: 0169-5002; 1872-8332
• DOI: 10.1016/j.lungcan.2016.04.010

Highlights • Subjects who develop lung cancer have a more pronounced increase in annual NLR and PLR. • Lung cancer incidence density is the highest in those with a more pronounced ratio increase. • Annual PLR increase is a significant lung cancer predictor among individuals with emphysema. • Annual PLR assessments could be of aid in a lung cancer screening setting.