Regulators of G Protein Signaling Proteins as Determinants of the Rate of Desensitization of Presynaptic Calcium Channels

Norepinephrine inhibits ω-conotoxin GVIA-sensitive presynaptic Ca2+ channels in chick dorsal root ganglion neurons through two pathways, one mediated by Go and the other by Gi. These pathways desensitize at different rates. We have found that recombinant Gα interacting protein (GAIP) and regulators...

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Bibliographic Details
Published in:	The Journal of biological chemistry Vol. 274; no. 20; pp. 14490 - 14494
Main Authors:	Diversé-Pierluissi, Marı́a A., Fischer, Thierry, Jordan, J. Dedrick, Schiff, Max, Ortiz, Daniel F., Farquhar, Marilyn G., De Vries, Luc
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 14-05-1999 American Society for Biochemistry and Molecular Biology
Subjects:	Amino Acid Sequence Animals binding binding proteins calcium Calcium Channel Blockers - pharmacology Calcium Channels - physiology Cells, Cultured Chick Embryo chickens dorsal root ganglia electric current Electrophysiology ganglia GTP Phosphohydrolases - physiology GTP-Binding Proteins - physiology GTPase-Activating Proteins guanosine triphosphate inorganic ions interactions ion transport Molecular Sequence Data Mollusk Venoms - pharmacology neurons Neurons - drug effects Neurons - physiology neurophysiology norepinephrine omega-Conotoxin GVIA Peptides - pharmacology Phosphoproteins - physiology Presynaptic Terminals - drug effects Presynaptic Terminals - physiology Proteins - physiology ras GTPase-Activating Proteins ras Proteins - physiology RGS Proteins Signal Transduction
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