Bone metabolism in oxalosis: a single-center study using new imaging techniques and biomarkers

• Published in: Pediatric nephrology (Berlin, West) Vol. 25; no. 6; pp. 1081 - 1089
• Main Authors: Bacchetta, Justine, Fargue, Sonia, Boutroy, Stéphanie, Basmaison, Odile, Vilayphiou, Nicolas, Plotton, Ingrid, Guebre-Egziabher, Fitsum, Dohin, Bruno, Kohler, Rémi, Cochat, Pierre
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01-06-2010; Springer; Springer Nature B.V
• Subjects: Adolescent; Alfacalcidol; Biological markers; Biomarkers - analysis; Bone and Bones - metabolism; Bones; Calcifediol; Child; Child, Preschool; Chronic kidney failure; Cross-Sectional Studies; Density; Female; Fibroblast growth factors; Fibroblast Growth Factors - blood; Fractures; Humans; Hyperoxaluria, Primary - metabolism; Hyperoxaluria, Primary - pathology; Imaging systems; Infant; Male; Medicine; Medicine & Public Health; Nephrology; Original Article; Oxalates; Oxalic acid; Pediatrics; Physiological aspects; Tomography, X-Ray Computed - methods; Urology; Vitamin D; Young Adult; France; Skeletal age; Primary hyperoxaluria; Children; Bone imaging; FGF23
• ISSN: 0931-041X; 1432-198X
• DOI: 10.1007/s00467-010-1453-x

The deposition of calcium oxalate crystals in the kidney and bone is a hallmark of primary hyperoxaluria type 1 (PH1). We report here an evaluation of the bone status of 12 PH1 children based on bone biomarkers [parathyroid hormone, vitamin D, fibroblast growth factor 23 (FGF23)] and radiological assessments (skeletal age, three-dimensional high-resolution peripheral quantitative computed tomography, HR-pQCT) carried out within the framework of a cross-sectional single-center study. The controls consisted of healthy and children with chronic kidney disease already enrolled in local bone and mineral metabolism studies. The mean age (±standard deviation) age of the patients was 99 (±63) months. Six children suffered from fracture. Bone maturation was accelerated in five patients, four of whom were <5 years. The combination of new imaging techniques and biomarkers highlighted new and unexplained features of PH1: advanced skeletal age in young PH1 patients, increased FGF23 levels and decreased total volumetric bone mineral density with bone microarchitecture alteration.