Immune parameters in a longitudinal study of a very old population of Swedish people: a comparison between survivors and nonsurvivors
As a part of an ongoing longitudinal investigation, this study examined relationships between survival and selected immune system parameters in a sample (n = 102) of very old individuals (86-92 years at the time of initial immune system data collection). Analyses were performed comparing initial tim...
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Published in: | The journals of gerontology. Series A, Biological sciences and medical sciences Vol. 50; no. 6; p. B378 |
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Main Authors: | , , , , |
Format: | Journal Article |
Language: | English |
Published: |
United States
01-11-1995
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Subjects: | |
Online Access: | Get more information |
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Summary: | As a part of an ongoing longitudinal investigation, this study examined relationships between survival and selected immune system parameters in a sample (n = 102) of very old individuals (86-92 years at the time of initial immune system data collection). Analyses were performed comparing initial time-point measurements from those individuals who were alive (n = 75) and those who were deceased (n = 27) two years after initial data collection. Immune system measurements consisted of determination of peripheral blood lymphocytes and lymphocyte subsets, as well as T-cell responses to activation by Concanavalin A. Cluster analysis identified a subgroup associated with nonsurvival which indicated characteristics that included: poor T-cell proliferative responses, high CD8 percentages, and low CD4 and CD19 percentages. This multivariate analysis suggested that combinations of immune system parameters predict two-year survival otherwise not apparent when single immune system parameters were evaluated in the elderly. |
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ISSN: | 1079-5006 |
DOI: | 10.1093/gerona/50a.6.b378 |