Exosome secretion by eosinophils: A possible role in asthma pathogenesis

Background Eosinophils secrete several granules that are involved in the propagation of inflammatory responses in patients with pathologies such as asthma. Objective We hypothesized that some of these granules are exosomes, which, when transferred to the recipient cells, could modulate asthma progre...

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Bibliographic Details
Published in:	Journal of allergy and clinical immunology Vol. 135; no. 6; pp. 1603 - 1613
Main Authors:	Mazzeo, Carla, PhD, Cañas, José Antonio, MSc, Zafra, Maria Paz, MSc, Rojas Marco, Ainara, MD, Fernández-Nieto, Mar, MD, PhD, Sanz, Veronica, VET, Mittelbrunn, María, PhD, Izquierdo, Manuel, PhD, Baixaulli, Francesc, MSc, Sastre, Joaquín, MD, PhD, del Pozo, Victoria, PhD
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-06-2015 Elsevier Limited
Subjects:	Allergy and Immunology Asthma Asthma - diagnosis Asthma - immunology Asthma - metabolism Asthma - pathology biomarker Biomarkers Biomarkers - analysis Biomarkers - metabolism Case-Control Studies CD63 Cell Fractionation Cell Separation Chemokine CCL11 - pharmacology Cytokines Disease endosomes eosinophils Eosinophils - drug effects Eosinophils - immunology Eosinophils - metabolism Eosinophils - ultrastructure exosomes Exosomes - immunology Exosomes - metabolism Exosomes - ultrastructure Humans IFN-γ Interferon-gamma - pharmacology lysobisphosphatidic acid Microscopy, Electron, Transmission multivesicular bodies Multivesicular Bodies - immunology Multivesicular Bodies - metabolism Multivesicular Bodies - ultrastructure Organelle Size Pathogenesis Patients Primary Cell Culture secretion Studies Western blot CD63 Protein kinase C Multivesicular body LBPA Major basic protein EPO lysobisphosphatidic acid eosinophils WB Eeosinophil peroxidase GFP MFI IFN-γ ILV exosomes MBP Mean fluorescence intensity endosomes PKC biomarker Asthma multivesicular bodies secretion ECP Transmission electron microscopy Green fluorescent protein MVB Eosinophil cationic protein Intraluminal vesicle TEM
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