Inhibition of peptidyl-arginine deiminases reverses protein-hypercitrullination and disease in mouse models of multiple sclerosis

Multiple sclerosis (MS) is the most common CNS-demyelinating disease of humans, showing clinical and pathological heterogeneity and a general resistance to therapy. We first discovered that abnormal myelin hypercitrullination, even in normal-appearing white matter, by peptidylarginine deiminases (PA...

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Bibliographic Details
Published in:	Disease models & mechanisms Vol. 6; no. 2; pp. 467 - 478
Main Authors:	Moscarello, Mario A, Lei, Helena, Mastronardi, Fabrizio G, Winer, Shawn, Tsui, Hubert, Li, Zhen, Ackerley, Cameron, Zhang, Li, Raijmakers, Reinout, Wood, D Denise
Format:	Journal Article
Language:	English
Published:	England The Company of Biologists Ltd 01-03-2013 The Company of Biologists Limited The Company of Biologists
Subjects:	Amidines - chemistry Amidines - pharmacology Amidines - therapeutic use Animals Apoptosis Binding sites Brain Brain - enzymology Brain - pathology CD3 Complex - metabolism Citrulline - metabolism Demyelinating Diseases - enzymology Demyelinating Diseases - pathology Disease Models, Animal Encephalomyelitis, Autoimmune, Experimental - drug therapy Encephalomyelitis, Autoimmune, Experimental - enzymology Encephalomyelitis, Autoimmune, Experimental - pathology Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Enzymes Humans Hydrolases - antagonists & inhibitors Hydrolases - metabolism Lymphocytes - drug effects Lymphocytes - pathology Mice Mice, Inbred C57BL Mice, Transgenic Multiple sclerosis Multiple Sclerosis - drug therapy Multiple Sclerosis - enzymology Multiple Sclerosis - pathology Optic Nerve - drug effects Optic Nerve - pathology Optic Nerve - ultrastructure Pathogenesis Peptides Protein expression Protein-Arginine Deiminases Proteins Spleen - drug effects Spleen - metabolism Spleen - pathology Survival Analysis
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