Primary structure of c‐kit: relationship with the CSF‐1/PDGF receptor kinase family–oncogenic activation of v‐kit involves deletion of extracellular domain and C terminus

The protein kinase domains of v‐kit, the oncogene of the acute transforming feline retrovirus HZ4‐FeSV (HZ4‐feline sarcoma virus), CSF‐1R (macrophage colony stimulating factor receptor) and PDGFR (platelet derived growth factor receptor) display extensive homology. Because of the close structural re...

Full description

Saved in:

Bibliographic Details
Published in:	The EMBO journal Vol. 7; no. 4; pp. 1003 - 1011
Main Authors:	Qiu, F. H., Ray, P., Brown, K., Barker, P. E., Jhanwar, S., Ruddle, F. H., Besmer, P.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group 01-04-1988
Subjects:	Amino Acid Sequence Animals Base Sequence Biological and medical sciences Cats Chromosome Deletion Chromosome Mapping DNA - genetics Fundamental and applied biological sciences. Psychology Gene Expression Regulation Genes Genes. Genome Humans Hybrid Cells - cytology Mice Molecular and cellular biology Molecular genetics Molecular Sequence Data Protein-Tyrosine Kinases - genetics Proto-Oncogene Proteins - genetics Proto-Oncogenes Receptor, ErbB-2 Receptors, Cell Surface - genetics Receptors, Colony-Stimulating Factor Receptors, Platelet-Derived Growth Factor Retroviridae - genetics RNA - genetics RNA - isolation & purification Proteins Vertebrata Mammalia C-Onc gene Malignant transformation V»-Onc gene Deletion Primary structure Activation Mechanism
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!