Skeletal functions of vitamin K-dependent proteins: not just for clotting anymore

• Published in: Nutrition reviews Vol. 55; no. 7; pp. 282 - 284
• Main Authors: Booth, S.L, Mayer, J
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01-07-1997; International Life Sciences Institute; Oxford University Press
• Subjects: ANIMAL TRANSGENIQUE; ANIMALES TRANSGENICOS; Animals; Biological and medical sciences; Bone and Bones - physiology; BONE FORMATION; BONE METABOLISM; BONES; Calcium-Binding Proteins - deficiency; Calcium-Binding Proteins - physiology; Extracellular Matrix Proteins; FORMACION OSEA; FORMATION DES OS; Fundamental and applied biological sciences. Psychology; HUESOS; Humans; LITERATURE REVIEWS; Matrix Gla Protein; MATRIX GLA PROTEINS; MATRIX PROTEINS; METABOLISM; METABOLISME; METABOLISMO; MICE; Mice, Transgenic; MICROBIAL PROTEINS; Nutrition; OSTEOCALCIN; Osteocalcin - deficiency; Osteocalcin - physiology; PEPTIDE; PEPTIDES; PEPTIDOS; PROTEINAS MICROBIANAS; PROTEINE MICROBIENNE; Proteins; RATON; Skeleton and joints; SOURIS; TRANSGENIC ANIMALS; Vertebrates: osteoarticular system, musculoskeletal system; VITAMIN K; Vitamin K - physiology; VITAMINA K; VITAMINE K; Vitamins; Animal model; Osteocalcin; Rodentia; Vitamin; GLA protein; Review; Biological activity; Ossification; Proteins; Osteoarticular system; Vertebrata; Mammalia; Mouse; Calcification; Bone; Vitamin K
• ISSN: 0029-6643; 1753-4887
• DOI: 10.1111/j.1753-4887.1997.tb01619.x

Osteocalcin and matrix Gla protein (MGP) are two vitamin K-dependent proteins present in bone and cartilage. Transgenic mice models were recently developed to isolate the function of each of these proteins. While osteocalcin-deficient mice have increased bone formation, MGP-deficient mice have abnormal calcification leading to osteopenia, fractures, and premature death owing to arterial calcification