Isolation of Flaviviruses and Alphaviruses with Encephalitogenic Potential Diagnosed by Evandro Chagas Institute (Pará, Brazil) in the Period of 1954-2022: Six Decades of Discoveries

• Published in: Viruses Vol. 15; no. 4; p. 935
• Main Authors: Wanzeller, Ana Lucia Monteiro, da Silva, Fabio Silva, Hernández, Leonardo Henrique Almeida, Barros, Landerson Junior Leopoldino, Freitas, Maria Nazaré Oliveira, Santos, Maissa Maia, Gonçalves, Ercília de Jesus, Pantoja, Jamilla Augusta Sousa, Lima, Creuza de Sousa, Lima, Maxwell Furtado, Costa, Luiz Roberto Oliveira, das Chagas, Liliane Leal, Silva, Iveraldo Ferreira, da Cunha, Tania Cristina Alves da Silveira, do Nascimento, Bruna Lais Sena, Vasconcelos, Helena Baldez, da Rosa, Elizabeth Salbe Travassos, Rodrigues, Sueli Guerreiro, Azevedo, Raimunda do Socorro da Silva, Martins, Lívia Carício, Casseb, Lívia Medeiros Neves, Chiang, Jannifer Oliveira, Nunes Neto, Joaquim Pinto, Cruz, Ana Cecília Ribeiro, Carvalho, Valéria Lima, Vasconcelos, Pedro Fernando da Costa, da Silva, Eliana Vieira Pinto
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01-04-2023; MDPI
• Subjects: Animals; arbovirus; Arboviruses; Arthropods; Blood transfusions; Brazil - epidemiology; Cell culture; Chikungunya virus; Dengue fever; Diagnosis; Disease; Disease hot spots; Eastern equine encephalitis; Encephalitis; Encephalitis Virus, St. Louis; Epidemics; Epidemiology; Flavivirus; Hemorrhage; Horses; Humans; Infections; Infectious diseases; Invasiveness; Mice; Mosquitoes; neurotropic; Public health; Reptiles & amphibians; Rodents; Vector-borne diseases; Venezuelan equine encephalitis; Vertebrates; Viral infections; viral isolation; Viruses; West Nile virus; Western equine encephalitis; Zika Virus; Zika Virus Infection; Brazil; Rio de Janeiro Brazil; Amazon Basin; United States > US; viral isolation; cell culture; public health; arbovirus; neurotropic
• ISSN: 1999-4915; 1999-4915
• DOI: 10.3390/v15040935

Viruses with encephalitogenic potential can cause neurological conditions of clinical and epidemiological importance, such as
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and
. The objective of the present study was to determine the number of arboviruses with neuroinvasive potential isolated in Brazil that corresponds to the collection of viral samples belonging to the Department of Arbovirology and Hemorrhagic Fevers, Evandro Chagas Institute (SAARB/IEC) of the Laboratory Network of National Reference for Arbovirus Diagnosis from 1954 to 2022. In the analyzed period, a total of 1,347 arbovirus samples with encephalitogenic potential were isolated from mice; 5,065 human samples were isolated exclusively by cell culture; and 676 viruses were isolated from mosquitoes. The emergence of new arboviruses may be responsible for diseases still unknown to humans, making the Amazon region a hotspot for infectious diseases due to its fauna and flora species characteristics. The detection of circulating arboviruses with the potential to cause neuroinvasive diseases is constant, which justifies the continuation of active epidemiological surveillance work that offers adequate support to the public health system regarding the virological diagnosis of circulating arboviruses in Brazil.