dHMG-Z, a second HMG-1-related protein in Drosophila melanogaster

• Published in: Nucleic acids research Vol. 21; no. 18; pp. 4369 - 4371
• Main Authors: Ner, S.S, Churchill, M.E.A, Searles, M.A, Travers, A.A
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 11-09-1993
• Subjects: amino acid sequences; Animals; Base Sequence; binding sites; Biological and medical sciences; Chromosome Mapping; complementary DNA; dhmg-z protein; DNA; dna recognition motif; DNA-binding proteins; Drosophila melanogaster; Drosophila melanogaster - embryology; Drosophila melanogaster - genetics; Drosophila melanogaster - metabolism; embryogenesis; Female; Fundamental and applied biological sciences. Psychology; genbank/x71139; gene expression; Genes. Genome; High Mobility Group Proteins - genetics; introns; Larva; loci; Male; messenger RNA; Molecular and cellular biology; Molecular genetics; Molecular Sequence Data; nucleotide sequences; RNA, Messenger - metabolism; structural genes; Embryonic development; Arthropoda; Insecta; High mobility group protein; Gene organization; Gene duplication; Invertebrata; Gene expression; Drosophila melanogaster; Diptera; Drosophilidae
• ISSN: 0305-1048; 1362-4962
• DOI: 10.1093/nar/21.18.4369

We report the identification of dHMG-Z, a gene related to dHMG-D and encoding a second invertebrate homologue of HMG 1 protein. The encoded proteins is 65% identical to dHMG-D protein, and also contains a single HMG-box as the DNA recognition motif. Analogous to dHMG-D, two transcripts are observed for dHMG-Z which are differentially regulated, and are the product of zygotic transcription unlike the dHMG-D transcripts which arise from both maternal and zygotic transcription. The genes for dHMG-D and dHMG-Z are located on adjacent loci in the genome and each contains two introns. The position of the second intron in the coding region is conserved between the two genes suggesting a common origin via gene duplication.