Hypercapnia impairs lung neutrophil function and increases mortality in murine pseudomonas pneumonia

Hypercapnia, an elevation of the level of carbon dioxide (CO2) in blood and tissues, is a marker of poor prognosis in chronic obstructive pulmonary disease and other pulmonary disorders. We previously reported that hypercapnia inhibits the expression of TNF and IL-6 and phagocytosis in macrophages i...

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Bibliographic Details
Published in:	American journal of respiratory cell and molecular biology Vol. 49; no. 5; pp. 821 - 828
Main Authors:	Gates, Khalilah L, Howell, Heather A, Nair, Aisha, Vohwinkel, Christine U, Welch, Lynn C, Beitel, Greg J, Hauser, Alan R, Sznajder, Jacob I, Sporn, Peter H S
Format:	Journal Article
Language:	English
Published:	United States American Thoracic Society 01-11-2013
Subjects:	Acidosis, Respiratory - immunology Acidosis, Respiratory - microbiology Animals Bacterial Load Disease Models, Animal Female HL-60 Cells Humans Hypercapnia - complications Hypercapnia - immunology Hypercapnia - pathology Inflammation Mediators - metabolism Interleukin-6 - metabolism Lung - immunology Lung - microbiology Lung - pathology Mice Mice, Inbred BALB C Neutrophils - immunology Neutrophils - microbiology Phagocytosis Pneumonia, Bacterial - complications Pneumonia, Bacterial - immunology Pneumonia, Bacterial - microbiology Pneumonia, Bacterial - pathology Pseudomonas aeruginosa - pathogenicity Reactive Oxygen Species - metabolism Time Factors Tumor Necrosis Factor-alpha - metabolism
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