Radiopharmaceutical Treatments for Cancer Therapy, Radionuclides Characteristics, Applications, and Challenges

• Published in: Molecules (Basel, Switzerland) Vol. 27; no. 16; p. 5231
• Main Authors: Salih, Suliman, Alkatheeri, Ajnas, Alomaim, Wijdan, Elliyanti, Aisyah
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01-08-2022; MDPI
• Subjects: alpha particles; Alpha rays; Antibodies; Antimitotic agents; Antineoplastic agents; auger electron; Beta particles; Beta rays; Binding sites; Biological products; Biology; Biomedical materials; Cancer; Cancer therapies; Care and treatment; Chemotherapy; Dosimetry; Drug delivery; Drug delivery systems; Drug dosages; Drug therapy; Drugs; Electrons; Energy; FDA approval; Health aspects; Hyperthyroidism; Medical imaging; Metastasis; Molecular biology; Monoclonal antibodies; Nanoparticles; nanotargeted therapy; Nanotechnology; Nuclear medicine; Patients; Peptides; Pharmaceuticals; Radiation therapy; Radiochemistry; Radioisotopes; radioligand therapy; Review; Thyroid cancer; Tumors; Vehicles; Viral antibodies; Serbia
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules27165231

Advances in the field of molecular biology have had an impact on biomedical applications, which provide greater hope for both imaging and therapeutics. Work has been intensified on the development of radionuclides and their application in radiopharmaceuticals (RPS) which will certainly influence and expand therapeutic approaches in the future treatment of patients. Alpha or beta particles and Auger electrons are used for therapy purposes, and each has advantages and disadvantages. The radionuclides labeled drug delivery system will deliver the particles to the specific targeting cell. Different radioligands can be chosen to uniquely target molecular receptors or intracellular components, making them suitable for personal patient-tailored therapy in modern cancer therapy management. Advances in nanotechnology have enabled nanoparticle drug delivery systems that can allow for specific multivalent attachment of targeted molecules of antibodies, peptides, or ligands to the surface of nanoparticles for therapy and imaging purposes. This review presents fundamental radionuclide properties with particular reference to tumor biology and receptor characteristic of radiopharmaceutical targeted therapy development.