Downregulation of angiotensin-converting enzyme 2 by the neuraminidase protein of influenza A (H1N1) virus

•We investigated the ACE2 levels after infection with influenza A (H1N1) virus.•Influenza infection results in downregulation of ACE2 protein levels that was dispensable for viral replication.•ACE2 downregulation was most likely related to ACE2 protein degradation by proteasome pathway rather than A...

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Bibliographic Details
Published in:	Virus research Vol. 185; pp. 64 - 71
Main Authors:	Liu, Xin, Yang, Ning, Tang, Jun, Liu, Song, Luo, Deyan, Duan, Qing, Wang, Xiliang
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 24-06-2014 Elsevier B.V. Published by Elsevier B.V
Subjects:	ACE2 Down-Regulation Downregulation Humans Influenza Influenza A Virus, H1N1 Subtype - enzymology Influenza A Virus, H1N1 Subtype - genetics Influenza A Virus, H1N1 Subtype - physiology Influenza, Human - enzymology Influenza, Human - genetics Influenza, Human - virology Neuraminidase Neuraminidase - genetics Neuraminidase - metabolism Peptidyl-Dipeptidase A - genetics Peptidyl-Dipeptidase A - metabolism Protein Processing, Post-Translational Viral Proteins - genetics Viral Proteins - metabolism Virus Replication ACE2 Downregulation Influenza Neuraminidase
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