Gene Expression and Proteome Analysis as Sources of Biomarkers in Basal Cell Carcinoma

Gene Expression and Proteome Analysis as Sources of Biomarkers in Basal Cell Carcinoma

Basal cell carcinoma (BCC) is the world’s leading skin cancer in terms of frequency at the moment and its incidence continues to rise each year, leading to profound negative psychosocial and economic consequences. UV exposure is the most important environmental factor in the development of BCC in ge...

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Published in:Disease markers Vol. 2016; no. 2016; pp. 1 - 9
Main Authors: Calenic, Bogdan, Greabu, Maria, Costea, Daniela Elena, Moraru, Liliana, Căruntu, Ana, Rosca, Adrian E., Voiculescu, Suzana, Voiculescu, Vlad, Ghita, Mihaela, Căruntu, Constantin, Lupu, Mihai, Popa, Iris Maria
Format: Journal Article
Language:English
Published: Cairo, Egypt Hindawi Publishing Corporation 01-01-2016
John Wiley & Sons, Inc
Subjects:
Animals
Basal cell carcinoma
Biological markers
Biomarkers - analysis
Cancer
Carcinoma, Basal Cell - genetics
Carcinoma, Basal Cell - metabolism
Carcinoma, Basal Cell - pathology
Development and progression
Diagnosis
Gene expression
Gene Expression Profiling
Genes
Genetic aspects
Genetic research
Humans
Mediation
Metastasis
Proteome - analysis
Proteomics - methods
Review
Skin
Skin Neoplasms - genetics
Skin Neoplasms - metabolism
Skin Neoplasms - pathology
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Abstract Basal cell carcinoma (BCC) is the world’s leading skin cancer in terms of frequency at the moment and its incidence continues to rise each year, leading to profound negative psychosocial and economic consequences. UV exposure is the most important environmental factor in the development of BCC in genetically predisposed individuals, this being reflected by the anatomical distribution of lesions mainly on sun-exposed skin areas. Early diagnosis and prompt management are of crucial importance in order to prevent local tissue destruction and subsequent disfigurement. Although various noninvasive or minimal invasive techniques have demonstrated their utility in increasing diagnostic accuracy of BCC and progress has been made in its treatment options, recurrent, aggressive, and metastatic variants of BCC still pose significant challenge for the healthcare system. Analysis of gene expression and proteomic profiling of tumor cells and of tumoral microenvironment in various tissues strongly suggests that certain molecules involved in skin cancer pathogenic pathways might represent novel predictive and prognostic biomarkers in BCC.
AbstractList Basal cell carcinoma (BCC) is the world's leading skin cancer in terms of frequency at the moment and its incidence continues to rise each year, leading to profound negative psychosocial and economic consequences. UV exposure is the most important environmental factor in the development of BCC in genetically predisposed individuals, this being reflected by the anatomical distribution of lesions mainly on sun-exposed skin areas. Early diagnosis and prompt management are of crucial importance in order to prevent local tissue destruction and subsequent disfigurement. Although various noninvasive or minimal invasive techniques have demonstrated their utility in increasing diagnostic accuracy of BCC and progress has been made in its treatment options, recurrent, aggressive, and metastatic variants of BCC still pose significant challenge for the healthcare system. Analysis of gene expression and proteomic profiling of tumor cells and of tumoral microenvironment in various tissues strongly suggests that certain molecules involved in skin cancer pathogenic pathways might represent novel predictive and prognostic biomarkers in BCC.
Audience Academic
Author Popa, Iris Maria
Rosca, Adrian E.
Căruntu, Ana
Ghita, Mihaela
Voiculescu, Suzana
Calenic, Bogdan
Lupu, Mihai
Greabu, Maria
Căruntu, Constantin
Costea, Daniela Elena
Moraru, Liliana
Voiculescu, Vlad
AuthorAffiliation 1 Department of Dermatology and Allergology, Elias Emergency University Hospital, 011461 Bucharest, Romania
8 Gade Laboratory for Pathology and Centre for Cancer Biomarkers (CCBio), Department of Clinical Medicine, University of Bergen, 5021 Bergen, Norway
7 Department of Biochemistry, Faculty of Dental Medicine, University of Medicine and Pharmacy “Carol Davila”, 050474 Bucharest, Romania
5 Department of Oral and Maxillofacial Surgery, “Carol Davila” Central Military Emergency Hospital, 010825 Bucharest, Romania
9 Department of Pathology, Haukeland University Hospital, 5021 Bergen, Norway
2 Department of Physiology, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania
6 Department of Plastic and Reconstructive Surgery, “Bagdasar Arseni” Clinical Emergency Hospital, 041915 Bucharest, Romania
3 Department of Dermatology, “Prof. N. C. Paulescu” National Institute of Diabetes, Nutrition and Metabolic Diseases, 020475 Bucharest, Romania
4 Dermatology Research Laboratory, “
AuthorAffiliation_xml – name: 4 Dermatology Research Laboratory, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania
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Author_xml – sequence: 1
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Snippet Basal cell carcinoma (BCC) is the world’s leading skin cancer in terms of frequency at the moment and its incidence continues to rise each year, leading to...
Basal cell carcinoma (BCC) is the world's leading skin cancer in terms of frequency at the moment and its incidence continues to rise each year, leading to...
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SubjectTerms Animals
Basal cell carcinoma
Biological markers
Biomarkers - analysis
Cancer
Carcinoma, Basal Cell - genetics
Carcinoma, Basal Cell - metabolism
Carcinoma, Basal Cell - pathology
Development and progression
Diagnosis
Gene expression
Gene Expression Profiling
Genes
Genetic aspects
Genetic research
Humans
Mediation
Metastasis
Proteome - analysis
Proteomics - methods
Review
Skin
Skin Neoplasms - genetics
Skin Neoplasms - metabolism
Skin Neoplasms - pathology
Title Gene Expression and Proteome Analysis as Sources of Biomarkers in Basal Cell Carcinoma
URI https://search.emarefa.net/detail/BIM-1103828
https://dx.doi.org/10.1155/2016/9831237
https://www.ncbi.nlm.nih.gov/pubmed/27578920
https://search.proquest.com/docview/1815975831
https://pubmed.ncbi.nlm.nih.gov/PMC4992754
Volume 2016
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