Influence of hepatitis C and hepatitis G virus co-infection on viral and cellular dynamics in patients infected with human immunodeficiency virus following interruption of highly active anti-retroviral therapy

• Published in: Clinical microbiology and infection Vol. 12; no. 3; pp. 290 - 293
• Main Authors: Soriano-Sarabia, N., Abad, M.-A., Vallejo, A., Gutiérrez, S., Leal, M.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Elsevier Ltd 01-03-2006; Blackwell Science Ltd; Blackwell
• Subjects: Adult; Anti-Retroviral Agents - therapeutic use; Antiretroviral Therapy, Highly Active; Biological and medical sciences; CD4 counts; CD4 Lymphocyte Count; Female; Flaviviridae Infections - complications; Hepatitis C - complications; Hepatitis C virus; Hepatitis G virus; Hepatitis, Viral, Human - complications; highly active anti-retroviral therapy; HIV Infections - complications; HIV Infections - drug therapy; HIV Infections - immunology; HIV Infections - virology; HIV-1; Hospitals, Urban; Human immunodeficiency virus; Human viral diseases; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Infectious diseases; Male; Medical sciences; Spain; Treatment Outcome; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Viral hepatitis; Viral Load; Withholding Treatment; Spain; hepatitis C virus; human immunodeficiency virus; hepatitis G virus; viral load; CD4 counts; highly active anti-retroviral therapy; Hepatic disease; Flavivirus; Microbiological investigation; Immunological investigation; T-Lymphocyte; Antiviral; Viral hepatitis G; Viral load; Viral hepatitis C; Hepatitis G virus; Immunopathology; Retroviridae; AIDS; Immune deficiency; Lentivirus; Infection; Virus; Chemotherapy; Treatment; Viral disease; Digestive diseases; Human immunodeficiency virus; Flaviviridae; Hepatitis C virus; Hepacivirus
• ISSN: 1198-743X; 1469-0691
• DOI: 10.1111/j.1198-743X.2005.01347.x

This study describes the influence of hepatitis C virus (HCV) and hepatitis G virus (HGV) co-infection on CD4 cell count decline and plasma human immunodeficiency virus (HIV) viral load in HIV-infected patients during a 1-year period following interruption of highly active anti-retroviral therapy (HAART) guided by CD4 count. CD4 cell count decline and plasma HIV viral load did not differ between HIV mono-infected patients and those patients co-infected with HCV and HGV. HCV genotype 1 had no apparent influence on the cellular and viral dynamics in HIV-infected patients compared with other HCV genotypes, although the unbalanced groups make larger studies desirable.